Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR9242Btlr/Mmmh
Stock Number:
068988-MU
Citation ID:
RRID:MMRRC_068988-MU
Other Names:
R9242 (G1)
Major Collection:

Strain Information

Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: Sox21, gt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Agpat4
Name: 1-acylglycerol-3-phosphate O-acyltransferase 4
Synonyms: 1500003P24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68262
Homologene: 69293
Helz
Name: helicase with zinc finger domain
Synonyms: 9630002H22Rik, 9430093I07Rik, 3110078M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Unk
Name: unkempt family zinc finger
Synonyms: B230379M23Rik, Zc3h5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,910,969 bp
  • G to T, chromosome 1 at 90,214,836 bp
  • A to G, chromosome 1 at 116,292,379 bp
  • G to T, chromosome 1 at 188,633,590 bp
  • A to G, chromosome 2 at 25,195,525 bp
  • A to G, chromosome 2 at 31,898,311 bp
  • G to A, chromosome 2 at 91,143,604 bp
  • G to T, chromosome 2 at 158,435,466 bp
  • C to A, chromosome 3 at 27,239,628 bp
  • C to T, chromosome 3 at 103,091,620 bp
  • G to A, chromosome 4 at 53,734,854 bp
  • T to C, chromosome 4 at 70,337,346 bp
  • C to T, chromosome 4 at 131,803,030 bp
  • C to A, chromosome 5 at 8,899,677 bp
  • G to T, chromosome 5 at 30,648,066 bp
  • G to T, chromosome 5 at 94,303,142 bp
  • A to G, chromosome 6 at 5,769,706 bp
  • T to A, chromosome 6 at 28,420,376 bp
  • C to T, chromosome 6 at 55,173,285 bp
  • C to T, chromosome 6 at 72,555,886 bp
  • C to G, chromosome 6 at 115,791,962 bp
  • T to A, chromosome 6 at 121,318,269 bp
  • T to C, chromosome 6 at 124,814,175 bp
  • T to A, chromosome 7 at 22,843,487 bp
  • T to C, chromosome 7 at 28,177,195 bp
  • C to T, chromosome 7 at 35,202,509 bp
  • A to T, chromosome 7 at 84,856,878 bp
  • C to T, chromosome 7 at 100,006,536 bp
  • C to T, chromosome 7 at 139,481,718 bp
  • T to C, chromosome 7 at 142,383,543 bp
  • C to T, chromosome 9 at 21,583,054 bp
  • T to A, chromosome 9 at 80,381,782 bp
  • A to T, chromosome 10 at 79,694,520 bp
  • T to A, chromosome 10 at 103,393,545 bp
  • A to G, chromosome 11 at 21,885,040 bp
  • T to C, chromosome 11 at 107,632,327 bp
  • T to C, chromosome 11 at 116,049,358 bp
  • T to A, chromosome 12 at 111,109,794 bp
  • G to A, chromosome 13 at 12,433,925 bp
  • T to C, chromosome 15 at 43,495,243 bp
  • T to C, chromosome 15 at 79,156,440 bp
  • T to C, chromosome 15 at 82,308,547 bp
  • T to A, chromosome 16 at 57,138,020 bp
  • A to G, chromosome 17 at 8,256,133 bp
  • G to T, chromosome 17 at 12,210,299 bp
  • G to T, chromosome 17 at 35,127,560 bp
  • A to T, chromosome 17 at 42,316,713 bp
  • A to G, chromosome 17 at 71,246,971 bp
  • A to G, chromosome 19 at 6,912,495 bp
  • T to A, chromosome 19 at 12,890,625 bp
  • A to G, chromosome 19 at 57,657,228 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068988-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.