Strain Name:
C57BL/6J-MtgxR9250Btlr/Mmmh
Stock Number:
068989-MU
Citation ID:
RRID:MMRRC_068989-MU
Other Names:
R9250 (G1)
Major Collection:

Strain Information

Sf1
Name: splicing factor 1
Synonyms: MZFM, Zfp162, CW17R, WBP4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22668
Homologene: 134065
Dapp1
Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms: Bam32
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26377
Homologene: 32138
Fam117a
Name: family with sequence similarity 117, member A
Synonyms: 5730593F17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215512
Homologene: 12775
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Exoc5
Name: exocyst complex component 5
Synonyms: Sec10l1, PRO1912, SEC10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105504
Homologene: 38195
Rp9
Name: retinitis pigmentosa 9 (human)
Synonyms: Rp9h, PAP-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 55934
VEGA: 9
Homologene: 10290
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: ALL-1, Mll1, HTRX1, trithorax Drosophila, Cxxc7, All1, Mll
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215445
Homologene: 49396
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: Zfp198, FIM, MYM, RAMP, SCLL
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, Hbxap, p325, 4832420A03Rik, C030033M12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, D8Ertd790e, kidney, anemia and testis
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Pxk
Name: PX domain containing serine/threonine kinase
Synonyms: D14Ertd813e, C230080L11Rik, MONaKA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218699
VEGA: 14
Homologene: 9828
Crim1
Name: cysteine rich transmembrane BMP regulator 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Nefm
Name: neurofilament, medium polypeptide
Synonyms: Nfm, NF-M, NF160, NF165, Nef3, neurofilament-M
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18040
HGNC: HGNC:7734
Homologene: 137211
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: Trp12, VRL-2, OTRPC4, 0610033B08Rik, VROAC, VR-OAC
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Runx2
Name: runt related transcription factor 2
Synonyms: polyomavirus enhancer binding factor 2 (PEBP2), Pebpa2a, Cbfa1, AML3, SL3-3 enhancer factor 1, PEBP2 alpha A, PEBP2aA, Osf2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Il31ra
Name: interleukin 31 receptor A
Synonyms: GPL, GLM-R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Gad1
Name: glutamate decarboxylase 1
Synonyms: GAD25, GAD44, GAD67, Gad-1, Z49976, EP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14415
HGNC: HGNC:4092
Homologene: 635
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Cdk12
Name: cyclin dependent kinase 12
Synonyms: Crk7, Crkrs, 1810022J16Rik, D11Ertd752e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Zfp644
Name: zinc finger protein 644
Synonyms: Zep-2, 1110068L01Rik, BM-005, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226999
Homologene: 20661
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546849
Homologene: 82586
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 1700081O04Rik, D12Ertd19e, 6030439O22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73490
Homologene: 16340
Or8b101
Name: olfactory receptor family 8 subfamily B member 101
Synonyms: MOR162-4, Olfr888, GA_x6K02T2PVTD-31787920-31788864
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258416
Homologene: 84577
Ptprh
Name: protein tyrosine phosphatase receptor type H
Synonyms: SAP-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329738
Homologene: 51892
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192193
Homologene: 33836
Cmklr1
Name: chemerin chemokine-like receptor 1
Synonyms: Gpcr27, ChemR23
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Fhl2
Name: four and a half LIM domains 2
Synonyms: SLIM3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14200
HGNC: HGNC:3703
Homologene: 20372
Aldh8a1
Name: aldehyde dehydrogenase 8 family, member A1
Synonyms: RALDH4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237320
Homologene: 23369
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320082
Homologene: 110776
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: 1700030F18Rik, LOC380973
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Ddt
Name: D-dopachrome tautomerase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13202
Homologene: 1038
Nubp2
Name: nucleotide binding protein 2
Synonyms: D17Wsu11e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26426
VEGA: 17
HGNC: HGNC:8042
Homologene: 8057
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268670
VEGA: 13
Or5w11
Name: olfactory receptor family 5 subfamily W member 11
Synonyms: MOR177-4, Olfr1131, GA_x6K02T2Q125-49133664-49134593
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258652
Homologene: 133019
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Or10ab4
Name: olfactory receptor family 10 subfamily AB member 4
Synonyms: MOR267-15, GA_x6K02T2PBJ9-10384085-10385068, Olfr479
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257891
Homologene: 79346
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Spef1l
Name: sperm flagellar 1 like
Synonyms: 6430531B16Rik, LOC381933
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381933
Homologene: 134514
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, Nope, WI-18508, WI-16786
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Mr1
Name: major histocompatibility complex, class I-related
Synonyms: MR1, H2ls
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15064
HGNC: HGNC:4975
Homologene: 123981
Mipep
Name: mitochondrial intermediate peptidase
Synonyms: 5730405E07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70478
VEGA: 14
HGNC: HGNC:7104
Homologene: 4337
Tas2r105
Name: taste receptor, type 2, member 105
Synonyms: mt2r5, mGR05, T2r5, T2R9, T2R05, Tas2r5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57252
Homologene: 69307
Unc93a
Name: unc-93 homolog A
Synonyms: Unc93l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381058
Homologene: 10356
Mmp7
Name: matrix metallopeptidase 7
Synonyms: MAT, matrilysin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17393
HGNC: HGNC:7174
Homologene: 37619
Igkv4-90
Name: immunoglobulin kappa chain variable 4-90
Synonyms: Gm16906
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434034
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 40,767,827 bp
  • A to G, chromosome 1 at 43,128,262 bp
  • A to G, chromosome 1 at 155,137,579 bp
  • A to G, chromosome 2 at 52,278,901 bp
  • T to A, chromosome 2 at 70,579,199 bp
  • T to C, chromosome 2 at 87,628,934 bp
  • T to C, chromosome 3 at 108,756,827 bp
  • G to T, chromosome 3 at 127,586,148 bp
  • T to C, chromosome 3 at 137,933,158 bp
  • C to G, chromosome 3 at 138,066,628 bp
  • A to T, chromosome 4 at 144,715,441 bp
  • A to G, chromosome 5 at 104,519,454 bp
  • T to G, chromosome 5 at 106,636,833 bp
  • A to G, chromosome 5 at 110,299,821 bp
  • G to C, chromosome 5 at 113,613,982 bp
  • T to C, chromosome 5 at 114,626,880 bp
  • C to A, chromosome 6 at 68,807,347 bp
  • T to C, chromosome 6 at 70,663,774 bp
  • C to A, chromosome 6 at 108,828,889 bp
  • T to G, chromosome 6 at 131,686,988 bp
  • T to A, chromosome 6 at 132,656,991 bp
  • T to A, chromosome 7 at 4,573,290 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,914 bp
  • T to G, chromosome 7 at 104,769,632 bp
  • C to A, chromosome 7 at 107,793,335 bp
  • C to T, chromosome 7 at 108,055,807 bp
  • C to A, chromosome 7 at 139,976,482 bp
  • T to C, chromosome 8 at 61,012,117 bp
  • A to T, chromosome 9 at 7,697,884 bp
  • G to A, chromosome 9 at 22,453,790 bp
  • T to A, chromosome 9 at 38,109,422 bp
  • G to A, chromosome 9 at 44,848,386 bp
  • A to G, chromosome 9 at 65,131,650 bp
  • A to T, chromosome 9 at 66,542,511 bp
  • A to G, chromosome 9 at 109,143,778 bp
  • T to C, chromosome 9 at 122,852,027 bp
  • T to C, chromosome 10 at 21,382,360 bp
  • T to C, chromosome 10 at 75,773,229 bp
  • C to A, chromosome 11 at 95,337,245 bp
  • T to C, chromosome 11 at 98,210,572 bp
  • A to G, chromosome 12 at 57,414,383 bp
  • G to T, chromosome 13 at 46,775,433 bp
  • T to G, chromosome 13 at 67,140,397 bp
  • A to T, chromosome 13 at 112,532,974 bp
  • T to A, chromosome 14 at 8,144,123 bp
  • T to C, chromosome 14 at 24,190,475 bp
  • A to T, chromosome 14 at 49,019,458 bp
  • T to A, chromosome 14 at 56,911,275 bp
  • T to C, chromosome 14 at 60,790,909 bp
  • T to C, chromosome 14 at 68,121,121 bp
  • A to G, chromosome 15 at 99,947,449 bp
  • A to G, chromosome 17 at 13,115,601 bp
  • A to G, chromosome 17 at 24,884,399 bp
  • G to T, chromosome 17 at 26,018,245 bp
  • T to C, chromosome 17 at 28,835,814 bp
  • A to G, chromosome 17 at 44,814,572 bp
  • C to T, chromosome 17 at 78,370,042 bp
  • A to G, chromosome 18 at 61,811,430 bp
  • C to T, chromosome 19 at 6,374,734 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9250 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.