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Strain Name:
C57BL/6J-MtgxR9192Btlr/Mmmh
Stock Number:
069037-MU
Citation ID:
RRID:MMRRC_069037-MU
Other Names:
R9192 (G1)
Major Collection:

Strain Information

Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
E2f7
Name: E2F transcription factor 7
Synonyms: A630014C11Rik, D10Ertd739e, E2F7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52679
Homologene: 18685
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76719
Homologene: 9140
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Jhdm1b, Fbxl10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 69,923,848 bp (GRCm38)
  • A to T, chromosome 1 at 78,499,240 bp (GRCm38)
  • T to C, chromosome 1 at 128,372,152 bp (GRCm38)
  • G to A, chromosome 1 at 156,310,816 bp (GRCm38)
  • A to T, chromosome 2 at 27,282,382 bp (GRCm38)
  • A to T, chromosome 2 at 36,091,133 bp (GRCm38)
  • T to C, chromosome 2 at 52,313,835 bp (GRCm38)
  • A to G, chromosome 2 at 76,914,911 bp (GRCm38)
  • A to G, chromosome 2 at 82,987,500 bp (GRCm38)
  • C to A, chromosome 2 at 90,401,372 bp (GRCm38)
  • A to T, chromosome 2 at 109,274,465 bp (GRCm38)
  • G to A, chromosome 2 at 121,456,769 bp (GRCm38)
  • T to A, chromosome 2 at 126,587,887 bp (GRCm38)
  • G to T, chromosome 3 at 64,491,517 bp (GRCm38)
  • A to T, chromosome 3 at 88,333,457 bp (GRCm38)
  • G to T, chromosome 4 at 72,118,516 bp (GRCm38)
  • A to G, chromosome 5 at 14,540,190 bp (GRCm38)
  • A to G, chromosome 5 at 24,377,613 bp (GRCm38)
  • T to C, chromosome 5 at 33,250,989 bp (GRCm38)
  • A to G, chromosome 5 at 37,629,000 bp (GRCm38)
  • T to C, chromosome 5 at 38,287,930 bp (GRCm38)
  • G to C, chromosome 5 at 106,637,963 bp (GRCm38)
  • T to A, chromosome 5 at 122,932,616 bp (GRCm38)
  • A to T, chromosome 5 at 123,865,291 bp (GRCm38)
  • T to G, chromosome 5 at 135,210,794 bp (GRCm38)
  • C to A, chromosome 5 at 142,787,847 bp (GRCm38)
  • T to A, chromosome 6 at 30,449,500 bp (GRCm38)
  • T to C, chromosome 6 at 76,496,583 bp (GRCm38)
  • T to C, chromosome 6 at 132,700,529 bp (GRCm38)
  • C to T, chromosome 7 at 7,115,934 bp (GRCm38)
  • T to A, chromosome 7 at 75,704,501 bp (GRCm38)
  • A to T, chromosome 7 at 104,040,668 bp (GRCm38)
  • A to G, chromosome 7 at 106,753,223 bp (GRCm38)
  • C to A, chromosome 7 at 123,189,953 bp (GRCm38)
  • G to A, chromosome 9 at 66,414,131 bp (GRCm38)
  • T to C, chromosome 9 at 115,167,226 bp (GRCm38)
  • C to T, chromosome 10 at 27,328,185 bp (GRCm38)
  • G to T, chromosome 10 at 110,763,990 bp (GRCm38)
  • G to A, chromosome 10 at 127,657,610 bp (GRCm38)
  • A to T, chromosome 11 at 69,236,477 bp (GRCm38)
  • A to G, chromosome 11 at 75,178,036 bp (GRCm38)
  • T to C, chromosome 11 at 86,513,555 bp (GRCm38)
  • A to T, chromosome 11 at 104,336,316 bp (GRCm38)
  • A to C, chromosome 12 at 64,474,116 bp (GRCm38)
  • A to G, chromosome 12 at 70,197,048 bp (GRCm38)
  • T to A, chromosome 12 at 76,109,929 bp (GRCm38)
  • T to A, chromosome 13 at 96,088,247 bp (GRCm38)
  • C to T, chromosome 14 at 20,719,520 bp (GRCm38)
  • C to G, chromosome 14 at 53,531,158 bp (GRCm38)
  • T to A, chromosome 15 at 99,037,856 bp (GRCm38)
  • C to A, chromosome 15 at 102,112,981 bp (GRCm38)
  • T to A, chromosome 16 at 20,654,662 bp (GRCm38)
  • C to T, chromosome 17 at 33,781,311 bp (GRCm38)
  • T to C, chromosome 17 at 54,287,361 bp (GRCm38)
  • A to T, chromosome 17 at 86,996,977 bp (GRCm38)
  • A to G, chromosome 18 at 24,679,537 bp (GRCm38)
  • A to G, chromosome 18 at 37,007,474 bp (GRCm38)
  • A to T, chromosome 18 at 37,726,110 bp (GRCm38)
  • A to G, chromosome 18 at 37,840,031 bp (GRCm38)
  • A to G, chromosome 18 at 61,000,577 bp (GRCm38)
  • G to A, chromosome 18 at 80,973,909 bp (GRCm38)
  • T to C, chromosome 19 at 3,804,442 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9192 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069037-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.