Strain Name:
C57BL/6J-MtgxR9289Btlr/Mmmh
Stock Number:
069108-MU
Citation ID:
RRID:MMRRC_069108-MU
Other Names:
R9289 (G1)
Major Collection:

Strain Information

Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, 0610038M01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224807
Homologene: 101682
Dlgap4
Name: DLG associated protein 4
Synonyms: DAP4, PSD-95/SAP90 binding protein 4, Sapap4, WBP16, SAP90/PSD-95-associated protein 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228836
Homologene: 8935
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: 2810449C13Rik, D330022K21Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Chka
Name: choline kinase alpha
Synonyms: Chk, choline/ethanolamine kinase alpha, EtnK-alpha, ChoK, CK/EK-alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12660
HGNC: HGNC:1937
Homologene: 88575
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2l2, 9630039I18Rik, 1810043M20Rik, Bat2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
C1qtnf1
Name: C1q and tumor necrosis factor related protein 1
Synonyms: CTRP1, 1600017K21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56745
Homologene: 10548
Glb1
Name: galactosidase, beta 1
Synonyms: Bge, Bgt, Bgl-t, C130097A14Rik, Bgl-e, Bgl-s, Bgl, Bgs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12091
VEGA: 9
HGNC: HGNC:4298
Homologene: 47922
Naa40
Name: N(alpha)-acetyltransferase 40, NatD catalytic subunit
Synonyms: 4931433E08Rik, Nat11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70999
VEGA: 19
Homologene: 41588
Fam219a
Name: family with sequence similarity 219, member A
Synonyms: 2310028H24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71901
Homologene: 51830
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Dgcr8
Name: DGCR8, microprocessor complex subunit
Synonyms: Gy1, N41, Vo59c07, D16H22S788E, D16H22S1742E, DiGeorge syndrome critical region gene 8, D16Wis2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94223
HGNC: HGNC:2847
Homologene: 11223
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103268
Homologene: 12254
Tmco5
Name: transmembrane and coiled-coil domains 5
Synonyms: 1700095F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67356
Homologene: 41661
Shtn1
Name: shootin 1
Synonyms: shootin1, 4930506M07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71653
VEGA: 19
Homologene: 41249
Mmp9
Name: matrix metallopeptidase 9
Synonyms: MMP-9, gelatinase B, Clg4b, Gelatinase B, B/MMP9, Gel B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Chia1
Name: chitinase, acidic 1
Synonyms: Chia, AMCase, 2200003E03Rik, YNL
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81600
Homologene: 75168
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Zfp839
Name: zinc finger protein 839
Synonyms: 2810455K09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72805
VEGA: 12
Homologene: 49541
Tbc1d20
Name: TBC1 domain family, member 20
Synonyms: 1110028I04Rik, bs, 2810442O16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67231
Homologene: 32574
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Ncdn
Name: neurochondrin
Synonyms: neurochondrin-2, neurochondrin-1, norbin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26562
Homologene: 8064
Pgm2l1
Name: phosphoglucomutase 2-like 1
Synonyms: BM32A, 4931406N15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70974
Homologene: 12374
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mouse
Chromosome: 11
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Dhx30
Name: DExH-box helicase 30
Synonyms: 2810477H02Rik, C130058C04Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 30, Ddx30, helG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72831
Homologene: 15779
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94089
Homologene: 14113
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Or2y14
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: Olfr1384, GA_x6K02T2QP88-5922712-5921756, MOR256-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258464
Homologene: 74259
Aurkb
Name: aurora kinase B
Synonyms: aurora B, Stk5, Aik2, STK-1, IPL1, Stk12, AIRK2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20877
Homologene: 55807
Tada3
Name: transcriptional adaptor 3
Synonyms: 1110004B19Rik, Tada3l, ADA3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101206
Homologene: 4633
Cmtm2b
Name: CKLF-like MARVEL transmembrane domain containing 2B
Synonyms: Cklfsf2b, 1700013O04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75502
Homologene: 88915
Or2n1d
Name: olfactory receptor family 2 subfamily N member 1D
Synonyms: Olfr136, GA_x6K02T2PSCP-2779375-2780313, MOR256-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258803
Homologene: 119758
1700018F24Rik
Name: RIKEN cDNA 1700018F24 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69396
Homologene: 86127
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, polaris, IFT88, Oak Ridge polycystic kidneys, orpk, fxo, Ttc10, TgN737Rpw, Tg737Rpw
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21821
Homologene: 4761
Or52n5
Name: olfactory receptor family 52 subfamily N member 5
Synonyms: GA_x6K02T2PBJ9-7567376-7568329, Olfr669, MOR34-6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259045
Homologene: 72057
Zfp78
Name: zinc finger protein 78
Synonyms: Zfp77, KRAB12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330463
Homologene: 128524
Rnf150
Name: ring finger protein 150
Synonyms: C030044C12Rik, A630007N06Rik, Greul5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
Plat
Name: plasminogen activator, tissue
Synonyms: tPA, D8Ertd2e, t-PA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Mzf1
Name: myeloid zinc finger 1
Synonyms: Zfp121, Znf42, Mzf2, Zfp98
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109889
Homologene: 9633
Slc52a2
Name: solute carrier protein 52, member 2
Synonyms: Rfvt2, 2010003P03Rik, GPCR42, Gpr172b, PAR2, D15Ertd747e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52710
VEGA: 15
Homologene: 56994
Trav16d-dv11
Name: T cell receptor alpha variable 16D-DV11
Synonyms: ENSMUSG00000072535
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 547329
Or2av9
Name: olfactory receptor family 2 subfamily AV member 9
Synonyms: MOR284-2, Olfr332, GA_x6K02T2NKPP-926908-927915
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257932
Homologene: 74137
Cd8b1
Name: CD8 subunit beta 1
Synonyms: Lyt-3, Ly-3, Ly-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12526
Homologene: 3621
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Scgb2b12
Name: secretoglobin, family 2B, member 12
Synonyms: Abpbg12, Gm9138
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668379
Homologene: 83171
Ring1
Name: ring finger protein 1
Synonyms: Ring1A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19763
Homologene: 68283
C1rb
Name: complement component 1, r subcomponent B
Synonyms: Gm8551, mC1rB
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667277
HGNC: HGNC:1246
Homologene: 1313
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 162,679,561 bp (GRCm38)
  • A to T, chromosome 2 at 104,787,248 bp (GRCm38)
  • G to A, chromosome 2 at 116,880,264 bp (GRCm38)
  • T to C, chromosome 2 at 152,311,342 bp (GRCm38)
  • G to T, chromosome 2 at 156,704,594 bp (GRCm38)
  • A to G, chromosome 2 at 164,954,880 bp (GRCm38)
  • A to T, chromosome 3 at 106,115,186 bp (GRCm38)
  • C to A, chromosome 4 at 41,521,942 bp (GRCm38)
  • A to C, chromosome 4 at 126,750,110 bp (GRCm38)
  • G to A, chromosome 4 at 137,613,685 bp (GRCm38)
  • C to T, chromosome 5 at 145,045,523 bp (GRCm38)
  • G to A, chromosome 6 at 71,329,793 bp (GRCm38)
  • A to G, chromosome 6 at 113,370,303 bp (GRCm38)
  • G to T, chromosome 6 at 124,575,313 bp (GRCm38)
  • T to C, chromosome 7 at 6,378,368 bp (GRCm38)
  • T to A, chromosome 7 at 13,051,607 bp (GRCm38)
  • T to C, chromosome 7 at 32,326,635 bp (GRCm38)
  • T to A, chromosome 7 at 100,270,422 bp (GRCm38)
  • T to C, chromosome 7 at 104,938,609 bp (GRCm38)
  • T to C, chromosome 7 at 118,145,416 bp (GRCm38)
  • T to C, chromosome 8 at 22,782,084 bp (GRCm38)
  • A to G, chromosome 8 at 82,990,353 bp (GRCm38)
  • C to T, chromosome 8 at 93,265,863 bp (GRCm38)
  • A to G, chromosome 8 at 104,322,348 bp (GRCm38)
  • T to C, chromosome 9 at 110,091,535 bp (GRCm38)
  • A to T, chromosome 9 at 110,093,121 bp (GRCm38)
  • C to A, chromosome 9 at 114,420,490 bp (GRCm38)
  • A to T, chromosome 10 at 41,731,086 bp (GRCm38)
  • A to G, chromosome 10 at 92,821,074 bp (GRCm38)
  • A to T, chromosome 11 at 6,218,355 bp (GRCm38)
  • A to T, chromosome 11 at 48,845,454 bp (GRCm38)
  • C to T, chromosome 11 at 49,513,808 bp (GRCm38)
  • T to A, chromosome 11 at 58,489,919 bp (GRCm38)
  • T to C, chromosome 11 at 69,050,349 bp (GRCm38)
  • T to A, chromosome 11 at 87,568,966 bp (GRCm38)
  • A to G, chromosome 11 at 115,994,361 bp (GRCm38)
  • A to G, chromosome 11 at 118,443,846 bp (GRCm38)
  • C to A, chromosome 12 at 81,982,079 bp (GRCm38)
  • T to A, chromosome 12 at 110,868,444 bp (GRCm38)
  • T to C, chromosome 13 at 12,432,727 bp (GRCm38)
  • T to C, chromosome 14 at 53,047,629 bp (GRCm38)
  • T to A, chromosome 14 at 57,480,742 bp (GRCm38)
  • G to A, chromosome 15 at 58,618,917 bp (GRCm38)
  • G to T, chromosome 15 at 76,540,275 bp (GRCm38)
  • C to A, chromosome 15 at 78,759,257 bp (GRCm38)
  • A to T, chromosome 15 at 100,173,271 bp (GRCm38)
  • C to T, chromosome 16 at 18,280,215 bp (GRCm38)
  • T to A, chromosome 16 at 93,771,793 bp (GRCm38)
  • A to G, chromosome 17 at 32,158,280 bp (GRCm38)
  • A to G, chromosome 17 at 34,022,573 bp (GRCm38)
  • A to T, chromosome 17 at 38,335,429 bp (GRCm38)
  • A to G, chromosome 17 at 45,664,771 bp (GRCm38)
  • T to G, chromosome 19 at 3,885,953 bp (GRCm38)
  • T to C, chromosome 19 at 7,234,120 bp (GRCm38)
  • T to C, chromosome 19 at 59,009,825 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9289 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.