Strain Name:
C57BL/6J-MtgxR9759Btlr/Mmmh
Stock Number:
070004-MU
Citation ID:
RRID:MMRRC_070004-MU
Other Names:
R9759 (G1)
Major Collection:

Strain Information

Pax3
Name: paired box 3
Synonyms: Pax-3, Splchl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18505
HGNC: HGNC:8617
Homologene: 22494
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: ne, 6030440P17Rik, my, 8430406N05Rik, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Snta1
Name: syntrophin, acidic 1
Synonyms: Snt1, alpha1-syntrophin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20648
Homologene: 2331
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13800
Homologene: 134005
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: RACK7, 3632413B07Rik, 1110013E22Rik, ZMYND8, 2010005I16Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Sirt1
Name: sirtuin 1
Synonyms: Sir2, Sir2alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 93759
Homologene: 56556
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 4933425I22Rik, 5830411K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71148
Homologene: 136176
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: E330032J19Rik, NY-REN-45, 4930438A20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226823
Homologene: 9395
4833420G17Rik
Name: RIKEN cDNA 4833420G17 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67392
VEGA: 13
Homologene: 18889
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22775
Homologene: 32076
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: 7330410C13Rik, A630023E24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64706
Homologene: 11224
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Abt1
Name: activator of basal transcription 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30946
Homologene: 134288
Doc2g
Name: double C2, gamma
Synonyms: D830013O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60425
Homologene: 11036
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619697
Homologene: 86604
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Mthfsd
Name: methenyltetrahydrofolate synthetase domain containing
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234814
Homologene: 11245
Kynu
Name: kynureninase
Synonyms: L-kynurenine hydrolase, 4432411A05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Pfpl
Name: pore forming protein-like
Synonyms: Epcs5, Epcs50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56093
VEGA: 19
Homologene: 130704
Hdac7
Name: histone deacetylase 7
Synonyms: Hdac7a, 5830434K02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56233
Homologene: 9124
Rbm12
Name: RNA binding motif protein 12
Synonyms: 9430070C08Rik, 5730420G12Rik, SWAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75710
HGNC: HGNC:9898
Homologene: 34993
Ift88
Name: intraflagellar transport 88
Synonyms: polaris, orpk, IFT88, Tg737, TgN737Rpw, Ttc10, fxo, Oak Ridge polycystic kidneys, Tg737Rpw
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21821
Homologene: 4761
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: Yspl1, SVCT3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22626
Homologene: 65865
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Mimt44, D8Ertd118e, Tim44, 0710005E20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
Ddx25
Name: DEAD box helicase 25
Synonyms: GRTH, DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30959
Homologene: 8310
Insm2
Name: insulinoma-associated 2
Synonyms: mlt 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56856
VEGA: 12
Homologene: 10651
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71706
Homologene: 41733
Timm8a2
Name: translocase of inner mitochondrial membrane 8A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223262
Homologene: 86868
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • ATT to ATTT, chromosome 1 at 75,133,281 bp (GRCm38)
  • A to G, chromosome 1 at 78,193,778 bp (GRCm38)
  • A to C, chromosome 1 at 182,014,346 bp (GRCm38)
  • G to A, chromosome 1 at 188,978,589 bp (GRCm38)
  • A to G, chromosome 2 at 43,679,869 bp (GRCm38)
  • G to T, chromosome 2 at 154,380,969 bp (GRCm38)
  • A to T, chromosome 2 at 156,096,626 bp (GRCm38)
  • A to C, chromosome 2 at 165,838,826 bp (GRCm38)
  • A to G, chromosome 3 at 53,655,497 bp (GRCm38)
  • C to T, chromosome 4 at 103,162,528 bp (GRCm38)
  • T to C, chromosome 5 at 147,886,424 bp (GRCm38)
  • T to C, chromosome 6 at 17,555,562 bp (GRCm38)
  • A to C, chromosome 7 at 10,489,789 bp (GRCm38)
  • T to C, chromosome 7 at 132,154,513 bp (GRCm38)
  • C to A, chromosome 8 at 4,267,707 bp (GRCm38)
  • A to G, chromosome 8 at 35,785,784 bp (GRCm38)
  • A to G, chromosome 8 at 121,097,876 bp (GRCm38)
  • C to T, chromosome 9 at 35,545,969 bp (GRCm38)
  • A to G, chromosome 10 at 63,320,737 bp (GRCm38)
  • A to G, chromosome 10 at 127,508,214 bp (GRCm38)
  • G to A, chromosome 11 at 66,075,118 bp (GRCm38)
  • A to T, chromosome 11 at 73,167,515 bp (GRCm38)
  • C to T, chromosome 12 at 55,600,605 bp (GRCm38)
  • C to A, chromosome 13 at 20,816,568 bp (GRCm38)
  • G to T, chromosome 13 at 23,422,269 bp (GRCm38)
  • G to T, chromosome 13 at 119,479,453 bp (GRCm38)
  • T to A, chromosome 14 at 57,434,799 bp (GRCm38)
  • A to T, chromosome 14 at 122,034,804 bp (GRCm38)
  • T to G, chromosome 15 at 71,463,840 bp (GRCm38)
  • C to T, chromosome 15 at 83,608,264 bp (GRCm38)
  • T to C, chromosome 15 at 97,802,108 bp (GRCm38)
  • A to G, chromosome 17 at 23,401,386 bp (GRCm38)
  • A to G, chromosome 17 at 57,025,925 bp (GRCm38)
  • A to T, chromosome 19 at 4,006,571 bp (GRCm38)
  • G to C, chromosome 19 at 12,428,933 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9759 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070004-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.