Strain Name:
C57BL/6J-Cd36obl/Mmucd
Stock Number:
010471-UCD
Citation ID:
RRID:MMRRC_010471-UCD
Other Names:
Oblivious
Major Collection:

Strain Information

Cd36obl
Name: CD36 molecule; oblivious
Synonyms: Cd36m1Btlr, obl
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Cd36
Name: CD36 molecule
Synonyms: Scarb3, FAT, fatty acid translocase
Type: Gene
Species: Mouse
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Genetic Alterations
The mutant represents a single point mutation that was induced by ENU mutagenesis.
Genotype Determination
Phenotype
Homozygous: Mice lack functional expression of CD36 and show increased susceptibility to gram positive bacteria such as Staphylococcus aureus and show a reduced response towards diacylglycerides that activate TLR2/6 (lipoteichoic acid and MALP-2).

Heterozygous: No functional phenotype but a reduced expression of CD36.
Mammalian Phenotype Terms
Allelic Composition: Cd36obl/Cd36obl (Genetic Background: C57BL/6-Cd36obl )

MeSH Terms
  • Aging/physiology
  • Animals
  • CD36 Antigens/genetics
  • CD36 Antigens/metabolism
  • Cell Line
  • Dimerization
  • Ethylnitrosourea/pharmacology
  • Gene Deletion
  • Glycerides/chemistry
  • Glycerides/metabolism
  • Glycerides/pharmacology
  • Homozygote
  • Humans
  • Immunologic Deficiency Syndromes/chemically induced
  • Lipopeptides
  • Membrane Glycoproteins/agonists
  • Membrane Glycoproteins/chemistry
  • Membrane Glycoproteins/deficiency
  • Membrane Glycoproteins/metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mutagenesis/drug effects
  • Mutation/genetics
  • Oligopeptides/chemical synthesis
  • Oligopeptides/chemistry
  • Oligopeptides/pharmacology
  • Peptidoglycan/chemistry
  • Peptidoglycan/metabolism
  • Peptidoglycan/pharmacology
  • Phenotype
  • Receptors, Cell Surface/agonists
  • Receptors, Cell Surface/chemistry
  • Receptors, Cell Surface/deficiency
  • Receptors, Cell Surface/metabolism
  • Signal Transduction
  • Staphylococcal Infections/genetics
  • Staphylococcal Infections/immunology
  • Staphylococcal Infections/metabolism
  • Staphylococcal Infections/microbiology
  • Staphylococcus aureus/chemistry
  • Staphylococcus aureus/physiology
  • Toll-Like Receptor 2
  • Toll-Like Receptors
  • Tumor Necrosis Factor-alpha/biosynthesis
  • Zymosan/pharmacology
Strain Development
The founder was identified in a G3 ENU mutagenesis screen. After identification of the oblivious phenodeviant, the (male) founder was crossed to a C57BL/6 mouse and backcrossed with 2 females to generate an N2 generation. Phenotypic carriers from this cross were selected and bred to generate a homozygote stock.
Suggested Control Mice
  • Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Apoptosis
  • Cardiovascular
  • Diabetes/Obesity
  • Immunology and Inflammation
  • Metabolism
  • Models for Human Disease
  • Neurobiology
Donor
Bruce Beutler, M.D., The Scripps Research Institute
Primary Reference
  • Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zahringer U, Beutler B. CD36 is a sensor of diacylglycerides. Nature. 2005 Feb 3;433(7025):523-7. (Medline PMID: 15690042)
  • For additional information see: Mutagenetix, a catalog of mutations identified in the Beutler Laboratory at The Scripps Research Institute.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
010471-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
010471-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
010471-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.