Strain Name:
C57BL/6J-Myd88poc/Mmucd
Stock Number:
010475-UCD
Citation ID:
RRID:MMRRC_010475-UCD
Other Names:
Pococurante, C57BL/6J-Myd88poc/Mmcd
Major Collection:

Strain Information

Myd88poc
Name: myeloid differentiation primary response gene 88; pococurante
Synonyms: Poc, Myd88m2Btlr
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Myd88
Name: myeloid differentiation primary response gene 88
Type: Gene
Species: Mouse
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17874
HGNC: HGNC:7562
Homologene: 1849
Genetic Alterations
MyD88-I179N
Genotype Determination
Phenotype
Homozygous: Similar to Myd88 knockout, but show normal response to MALP2 and PAM2.

Heterozygous: Same as wild type
Mammalian Phenotype Terms
Allelic Composition: Myd88poc/Myd88poc (Genetic Background: C57BL/6-Myd88poc )

Allelic Composition: Myd88poc/Myd88+ (Genetic Background: C57BL/6-Myd88poc )

MeSH Terms
  • Adaptor Proteins, Signal Transducing/chemistry
  • Adaptor Proteins, Signal Transducing/deficiency
  • Adaptor Proteins, Signal Transducing/genetics
  • Adaptor Proteins, Signal Transducing/metabolism
  • Amino Acid Motifs
  • Animals
  • Cell Line
  • Germ Cells/metabolism
  • Humans
  • Lipoproteins/metabolism
  • Mice
  • Mice, Knockout
  • Models, Molecular
  • Molecular Sequence Data
  • Mutagenesis/genetics
  • Myeloid Differentiation Factor 88
  • Phenotype
  • Protein Binding
  • Protein Structure, Quaternary
  • Signal Transduction
  • Toll-Like Receptors/chemistry
  • Toll-Like Receptors/deficiency
  • Toll-Like Receptors/genetics
  • Toll-Like Receptors/metabolism
  • Alleles
  • Autoimmune Diseases/genetics
  • Autoimmune Diseases/immunology
  • Autoimmune Diseases/microbiology
  • Autoimmunity/genetics
  • Ethylnitrosourea/pharmacology
  • Homozygote
  • Inflammation/genetics
  • Inflammation/immunology
  • Inflammation/microbiology
  • Interleukin-1/genetics
  • Interleukin-1/immunology
  • Interleukin-1 Receptor-Associated Kinases/genetics
  • Interleukin-1 Receptor-Associated Kinases/immunology
  • Listeriosis/immunology
  • Mice, Mutant Strains
  • Mutagenesis
  • Mutation
  • Myeloid Differentiation Factor 88/genetics
  • Myeloid Differentiation Factor 88/immunology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6/genetics
  • Receptors, Interleukin-1/immunology
  • Toll-Like Receptors/immunology
Strain Development
Homozygous mutant was picked up by the screening, and backcrossed to its parents, after that homozygotes were kept by sib-mating.
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Immunology and Inflammation
  • Virology
Donor
Bruce Beutler, M.D., The Scripps Research Institute
Primary Reference
  • Jiang Z; Georgel P; Li C; Choe J; Crozat K; Rutschmann S; Du X; Bigby T; Mudd S; Sovath S; Wilson IA; Olson A; Beutler B, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis., Proc Natl Acad Sci U S A 2006 Jul 18;103(29):10961-6 (Medline PMID: 16832055)
  • Croker BA; Lawson BR; Berger M; Eidenschenk C; Blasius AL; Moresco EM; Sovath S; Cengia L; Shultz LD; Theofilopoulos AN; Pettersson S; Beutler BA, Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger., Proc Natl Acad Sci U S A 2008 Sep 30;105(39):15028-33 (Medline PMID: 18806225)
  • For additional information see: Mutagenetix, a catalog of mutations identified in the Beutler Laboratory at The Scripps Research Institute.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
010475-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
010475-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
010475-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.