Strain Name:
C57BL/6J-MtgxR0295Btlr/Mmmh
Stock Number:
038512-MU
Citation ID:
RRID:MMRRC_038512-MU
Other Names:
R0295 (G1), C57BL/6J-MtgxR0295Btlr
Major Collection:

Strain Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, Myhc-b, B-MHC, beta-MHC, betaMHC, MyHC-I, Myhcb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Rgs16
Name: regulator of G-protein signaling 16
Synonyms: Rgsr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19734
HGNC: HGNC:9997
Homologene: 2196
Ifng
Name: interferon gamma
Synonyms: Ifg, IFN-gamma
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15978
VEGA: 10
HGNC: HGNC:5438
Homologene: 55526
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: Sur, SUR1, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur4, spkw1, Gluralpha4, Glur-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: ubiquitin activating enzyme 3, Ube1c, A830034N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22200
Homologene: 2951
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Knl1
Name: kinetochore scaffold 1
Synonyms: 5730505K17Rik, Casc5, 2310043D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213895
Homologene: 7065
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213499
Homologene: 16234
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Rnf121
Name: ring finger protein 121
Synonyms: 4930544L10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75212
Homologene: 10132
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Zfp292
Name: zinc finger protein 292
Synonyms: 5730450D02Rik, Krox-10, Zfp15, Zfp-15, 9430062L07Rik, Zn-16, Zn-15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Ralgps2
Name: Ral GEF with PH domain and SH3 binding motif 2
Synonyms: 1810020P17Rik, 2210408F11Rik, 9130014M22Rik, 4921528G01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78255
Homologene: 23421
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Podxl2
Name: podocalyxin-like 2
Synonyms: D130074J02Rik, Endoglycan, PODLX2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319655
Homologene: 9254
Etv6
Name: ets variant 6
Synonyms: Tel, translocation-ets-leukemia
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14011
HGNC: HGNC:3495
Homologene: 37560
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Mesd
Name: mesoderm development LRP chaperone
Synonyms: Mesdc2, 2210015O11Rik, msd
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67943
Homologene: 11347
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 252972
Homologene: 9905
Dph2
Name: DPH2 homolog
Synonyms: 9130020C19Rik, Dph2l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67728
HGNC: HGNC:3004
Homologene: 1060
Ccdc127
Name: coiled-coil domain containing 127
Synonyms: 5430420E17Rik, 0610011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67433
Homologene: 11482
Myo6
Name: myosin VI
Synonyms: Myo6rsv, rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: B430006D22Rik, D230004J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
2610028H24Rik
Name: RIKEN cDNA 2610028H24 gene
Synonyms: ORF67
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76964
HGNC: HGNC:1300
Homologene: 50540
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
St6gal1
Name: beta galactoside alpha 2,6 sialyltransferase 1
Synonyms: Siat1, ST6Gal I, St6Gal-I
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20440
Homologene: 2281
Slc17a3
Name: solute carrier family 17 (sodium phosphate), member 3
Synonyms: Npt4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105355
Homologene: 21319
Timm29
Name: translocase of inner mitochondrial membrane 29
Synonyms: 1810026J23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69773
Homologene: 34702
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Or4k36
Name: olfactory receptor family 4 subfamily K member 36
Synonyms: MOR248-1, Olfr1280, GA_x6K02T2Q125-72366920-72367837
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258910
Homologene: 121540
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381678
Homologene: 9944
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Trim46
Name: tripartite motif-containing 46
Synonyms: TRIFIC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 360213
Homologene: 11815
Prss36
Name: serine protease 36
Synonyms: polyserase-2, C330007D15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77613
Homologene: 18303
Or5p1
Name: olfactory receptor family 5 subfamily P member 1
Synonyms: GA_x6K02T2PBJ9-10646917-10647849, MOR204-11, Olfr491
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258731
Homologene: 128150
Ildr1
Name: immunoglobulin-like domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106347
Homologene: 15892
Pdzd7
Name: PDZ domain containing 7
Synonyms: EG435601, Pdzk7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Fbxo8
Name: F-box protein 8
Synonyms: Fbx8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50753
Homologene: 8137
Lcp1
Name: lymphocyte cytosolic protein 1
Synonyms: L-plastin, Pls2, L-fimbrin, D14Ertd310e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18826
HGNC: HGNC:6528
Homologene: 80174
H2aj
Name: H2J.A histone
Synonyms: H2afj
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232440
Homologene: 128575
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, Oprk2, R21
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329416
Homologene: 43142
Cstpp1
Name: centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Synonyms: 1110051M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228356
Homologene: 11471
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71710
Homologene: 12559
Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms: mouse class II type ADH, Adh2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26876
HGNC: HGNC:252
Homologene: 20162
Zfp956
Name: zinc finger protein 956
Synonyms: AI894139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101197
Homologene: 128449
Zscan4e
Name: zinc finger and SCAN domain containing 4E
Synonyms: EG665848
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665848
Homologene: 85986
Nosip
Name: nitric oxide synthase interacting protein
Synonyms: 2310061K06Rik, CGI-25
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66394
Homologene: 9315
Or51v8
Name: olfactory receptor family 51 subfamily V member 8
Synonyms: MOR4-2P, Olfr624, GA_x6K02T2PBJ9-6394126-6393197
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258189
Homologene: 66460
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 1700018I02Rik, Ccdc99, 2600001J17Rik, 2810049B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70385
Homologene: 9837
Slfn8
Name: schlafen 8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276950
Homologene: 45432
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: D11Moh44e, 4932418K24Rik, D11Moh43e, t8130b59
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237930
Homologene: 18229
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: DC-LAMP, Cd208, 1200002D17Rik, TSC403
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Or2n1d
Name: olfactory receptor family 2 subfamily N member 1D
Synonyms: Olfr136, GA_x6K02T2PSCP-2779375-2780313, MOR256-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258803
Homologene: 119758
Med14
Name: mediator complex subunit 14
Synonyms: Crsp2, Trap170, LOC270579, 9930001L01Rik, ENSMUSG00000073278, ORF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 26896
HGNC: HGNC:2370
Homologene: 22082
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 5,598,850 bp
  • A to T, chromosome 1 at 144,245,486 bp
  • A to G, chromosome 1 at 153,743,737 bp
  • T to A, chromosome 1 at 156,823,985 bp
  • T to C, chromosome 2 at 52,284,285 bp
  • A to C, chromosome 2 at 69,179,416 bp
  • A to T, chromosome 2 at 76,758,611 bp
  • A to T, chromosome 2 at 91,282,594 bp
  • T to A, chromosome 2 at 111,316,154 bp
  • A to C, chromosome 2 at 119,088,839 bp
  • A to T, chromosome 3 at 14,565,849 bp
  • A to G, chromosome 3 at 89,245,113 bp
  • A to G, chromosome 3 at 138,429,076 bp
  • A to T, chromosome 4 at 34,806,281 bp
  • A to T, chromosome 4 at 117,890,930 bp
  • A to G, chromosome 4 at 141,200,497 bp
  • A to T, chromosome 5 at 108,173,789 bp
  • T to A, chromosome 5 at 120,539,060 bp
  • A to C, chromosome 5 at 136,313,212 bp
  • G to T, chromosome 5 at 137,817,472 bp
  • A to G, chromosome 6 at 47,957,610 bp
  • G to A, chromosome 6 at 83,369,139 bp
  • A to T, chromosome 6 at 88,849,678 bp
  • A to T, chromosome 6 at 97,191,583 bp
  • A to G, chromosome 6 at 118,389,337 bp
  • A to G, chromosome 6 at 134,266,275 bp
  • A to T, chromosome 6 at 134,457,693 bp
  • C to G, chromosome 6 at 136,808,604 bp
  • A to G, chromosome 7 at 11,307,616 bp
  • T to A, chromosome 7 at 45,076,916 bp
  • T to C, chromosome 7 at 46,118,054 bp
  • T to A, chromosome 7 at 67,669,852 bp
  • T to A, chromosome 7 at 82,548,005 bp
  • C to T, chromosome 7 at 83,897,865 bp
  • A to G, chromosome 7 at 102,035,346 bp
  • T to C, chromosome 7 at 103,670,311 bp
  • T to G, chromosome 7 at 108,317,685 bp
  • T to G, chromosome 7 at 127,935,855 bp
  • G to A, chromosome 8 at 56,590,074 bp
  • T to C, chromosome 9 at 4,793,840 bp
  • T to C, chromosome 9 at 21,593,076 bp
  • T to C, chromosome 9 at 80,283,579 bp
  • T to C, chromosome 9 at 96,545,810 bp
  • G to A, chromosome 10 at 76,454,808 bp
  • A to C, chromosome 10 at 100,537,821 bp
  • G to T, chromosome 10 at 118,441,249 bp
  • A to T, chromosome 11 at 34,813,343 bp
  • A to G, chromosome 11 at 69,030,588 bp
  • A to T, chromosome 11 at 83,003,343 bp
  • A to G, chromosome 11 at 85,053,692 bp
  • G to T, chromosome 11 at 96,154,714 bp
  • T to A, chromosome 12 at 8,002,181 bp
  • C to T, chromosome 13 at 23,855,858 bp
  • C to A, chromosome 13 at 74,356,870 bp
  • T to C, chromosome 13 at 89,712,191 bp
  • A to G, chromosome 14 at 54,984,821 bp
  • A to G, chromosome 14 at 75,199,420 bp
  • T to A, chromosome 15 at 80,356,211 bp
  • C to T, chromosome 16 at 14,142,534 bp
  • A to T, chromosome 16 at 19,701,108 bp
  • T to A, chromosome 16 at 23,356,203 bp
  • A to G, chromosome 16 at 36,709,477 bp
  • A to T, chromosome 17 at 38,335,291 bp
  • T to C, chromosome 17 at 74,613,362 bp
  • A to G, chromosome 19 at 45,037,072 bp
  • G to C, chromosome X at 12,685,748 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0295 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038512-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.