Strain Name:
C57BL/6J-MtgxR0837Btlr/Mmmh
Stock Number:
039016-MU
Citation ID:
RRID:MMRRC_039016-MU
Other Names:
R0837 (G1), C57BL/6J-MtgxR0837Btlr
Major Collection:

Strain Information

Prnp
Name: prion protein
Synonyms: PrPSc, Prn-p, CD230, Sinc, PrPC, PrP, Prn-i
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19122
HGNC: HGNC:9449
Homologene: 7904
Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngrh1, Ngr2, Ngrl3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269295
Homologene: 18683
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Usp7
Name: ubiquitin specific peptidase 7
Synonyms: 2210010O09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 252870
Homologene: 2592
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: 4.1G, D10Ertd398e, Epb4.1l2, NBL2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b-2, Cyp11b, aldosterone synthase, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22241
Homologene: 2640
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, Ttc15, D930014A20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217449
VEGA: 12
Homologene: 34805
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: 2700084A17Rik, Syp, SHP-2, SH-PTP2, PTP1D, PTP2C, Shp2, SH2 domain-containing protein tyrosine phosphatase-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: D8Ertd374e, gamma-adaptin, Adtg
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: 2610024B04Rik, 100kDa, Cpsf
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22767
Homologene: 56456
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Rab40c
Name: Rab40C, member RAS oncogene family
Synonyms: RAR3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224624
Homologene: 10907
Sema4a
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Synonyms: SemB, Semab, SemB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20351
Homologene: 8425
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: Ccdc64, 2210403N09Rik, BICDR-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75665
Homologene: 18013
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Tnfaip2
Name: tumor necrosis factor, alpha-induced protein 2
Synonyms: Tnfip2, M-sec, Exoc3l3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21928
Homologene: 4583
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Fip200, 2900055E04Rik, 5930404L04Rik, Cc1, LaXp180
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241514
Homologene: 18461
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Kcnq4
Name: potassium voltage-gated channel, subfamily Q, member 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 60613
HGNC: HGNC:6298
Homologene: 78107
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
4930563I02Rik
Name: RIKEN cDNA 4930563I02 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67659
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 2310039H01Rik, 5730419A02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68291
Homologene: 5876
Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Synonyms: 2310020H23Rik, 1110034I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107885
Homologene: 4702
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 9130206N08Rik, 2010013I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103406
Homologene: 88124
4930579C12Rik
Name: RIKEN cDNA 4930579C12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319213
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: Plfr, PLF-RP, PRP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18814
Homologene: 7894
Or10aa1
Name: olfactory receptor family 10 subfamily AA member 1
Synonyms: Olfr433, GA_x6K02T2P20D-21133014-21132070, MOR123-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258712
Homologene: 133588
H2ac21
Name: H2A clustered histone 21
Synonyms: Hist2h2ab, H2a-613a, EG621893
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 621893
Homologene: 111318
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,234,271 bp
  • G to A, chromosome 1 at 66,648,944 bp
  • A to G, chromosome 1 at 174,042,487 bp
  • A to C, chromosome 2 at 82,259,162 bp
  • T to C, chromosome 2 at 84,880,692 bp
  • A to T, chromosome 2 at 131,936,524 bp
  • T to A, chromosome 3 at 88,453,098 bp
  • G to A, chromosome 3 at 96,220,123 bp
  • G to T, chromosome 3 at 102,915,245 bp
  • C to T, chromosome 4 at 98,989,258 bp
  • T to A, chromosome 4 at 120,746,861 bp
  • G to A, chromosome 5 at 87,411,773 bp
  • A to T, chromosome 5 at 110,789,545 bp
  • G to A, chromosome 5 at 115,731,292 bp
  • C to T, chromosome 5 at 121,149,111 bp
  • A to T, chromosome 6 at 118,630,270 bp
  • G to A, chromosome 6 at 136,722,420 bp
  • G to A, chromosome 6 at 139,957,699 bp
  • T to A, chromosome 7 at 5,488,027 bp
  • T to C, chromosome 7 at 96,896,275 bp
  • T to A, chromosome 8 at 43,651,500 bp
  • A to G, chromosome 8 at 85,096,829 bp
  • T to C, chromosome 8 at 109,851,065 bp
  • C to A, chromosome 9 at 7,077,979 bp
  • A to T, chromosome 9 at 55,859,042 bp
  • A to T, chromosome 9 at 78,473,790 bp
  • A to G, chromosome 9 at 89,168,207 bp
  • A to G, chromosome 9 at 89,215,390 bp
  • C to T, chromosome 10 at 25,507,816 bp
  • A to G, chromosome 10 at 81,245,408 bp
  • T to C, chromosome 11 at 44,524,988 bp
  • A to G, chromosome 11 at 60,487,251 bp
  • A to G, chromosome 12 at 28,703,597 bp
  • C to T, chromosome 12 at 101,997,242 bp
  • A to G, chromosome 12 at 111,450,707 bp
  • T to A, chromosome 13 at 27,714,338 bp
  • T to C, chromosome 13 at 77,100,948 bp
  • T to A, chromosome 13 at 100,230,743 bp
  • T to C, chromosome 14 at 60,095,926 bp
  • G to A, chromosome 15 at 74,853,641 bp
  • C to A, chromosome 16 at 8,703,502 bp
  • A to G, chromosome 17 at 19,793,927 bp
  • G to A, chromosome 17 at 25,884,693 bp
  • A to T, chromosome Y at 725,850 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039016-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.