Strain Name:
C57BL/6J-MtgxR1054Btlr/Mmmh
Stock Number:
039144-MU
Citation ID:
RRID:MMRRC_039144-MU
Other Names:
R1054 (G1), C57BL/6J-MtgxR1054Btlr
Major Collection:

Strain Information

Npc2
Name: NPC intracellular cholesterol transporter 2
Synonyms: HE1, 2700012J19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67963
VEGA: 12
Homologene: 4697
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223666
Homologene: 27825
Timmdc1
Name: translocase of inner mitochondrial membrane domain containing 1
Synonyms: 4930455C21Rik, 2810021C21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76916
HGNC: HGNC:1321
Homologene: 9578
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, 4930537L06Rik, Pdzk3, A930022H17Rik, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Med25
Name: mediator complex subunit 25
Synonyms: ESTM2, 2610034E13Rik, 2610529E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75613
Homologene: 12614
Txnrd3
Name: thioredoxin reductase 3
Synonyms: Tgr, TR2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232223
Homologene: 60033
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, Tce4, 5830477H08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Wipf2
Name: WAS/WASL interacting protein family, member 2
Synonyms: 1110014J05Rik, 5730509C05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68524
Homologene: 15777
Gnat1
Name: G protein subunit alpha transducin 1
Synonyms: Ird1, Tralpha, Gnat-1, Ird2, transducin, irdr
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14685
HGNC: HGNC:4393
Homologene: 20084
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: Ddx32, DEAH (Asp-Glu-Ala-His) box polypeptide 32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Gtf2f2
Name: general transcription factor IIF, polypeptide 2
Synonyms: 1110031C13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68705
VEGA: 14
HGNC: HGNC:4653
Homologene: 37884
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, Taf2c2, 2610524B04Rik, TAFII105
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Cfap70
Name: cilia and flagella associated protein 70
Synonyms: 5330402L21Rik, Ttc18
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76670
Homologene: 17048
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213945
Homologene: 66345
Or52h1
Name: olfactory receptor family 52 subfamily H member 1
Synonyms: MOR31-12, GA_x6K02T2PBJ9-6914780-6913830, Olfr648
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258746
Homologene: 82999
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Dusp8
Name: dual specificity phosphatase 8
Synonyms: 5530400B01Rik, Nttp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: Eif3s5, 0610037M02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270162
VEGA: 9
Homologene: 10280
Gm4934
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101095
Homologene: 2647
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Sdr16c6
Name: short chain dehydrogenase/reductase family 16C, member 6
Synonyms: 4833413O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242286
Homologene: 135698
Arhgef38
Name: Rho guanine nucleotide exchange factor 38
Synonyms: D630013G24Rik, 9130221D24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77669
Homologene: 137396
Pou3f2
Name: POU domain, class 3, transcription factor 2
Synonyms: Brn2, Brn-2, A230098E07Rik, Otf7, 9430075J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18992
HGNC: HGNC:9215
Homologene: 4095
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17844
Homologene: 74304
Or6p1
Name: olfactory receptor family 6 subfamily P member 1
Synonyms: Olfr414, MOR103-10, GA_x6K02T2P20D-20749615-20748662
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258756
Homologene: 17383
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: Tmbim1b, Lfg5, 4930511M11Rik, 4930500J03Rik, 4930403J02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75010
Homologene: 81927
Qrsl1
Name: glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms: GatA, 2700038P16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76563
Homologene: 6699
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: ELK1, Kv12.1, C130090D05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Mcad, Cdh14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223433
VEGA: 15
Homologene: 41302
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Tmem74b
Name: transmembrane protein 74B
Synonyms: 5430405G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108832
Homologene: 10148
Cpne4
Name: copine IV
Synonyms: 4933406O10Rik, 3632411M23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74020
HGNC: HGNC:2317
Homologene: 26078
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171246
Homologene: 110880
Hacd4
Name: 3-hydroxyacyl-CoA dehydratase 4
Synonyms: Ptplad2, 4933428I03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66775
Homologene: 12033
Gm17661
Name: predicted gene, 17661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Arv1
Name: ARV1 homolog, fatty acid homeostasis modulator
Synonyms: 1110067L22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68865
Homologene: 41498
Rpl13-ps3
Name: ribosomal protein L13, pseudogene 3
Synonyms: Gm9026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 668182
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,311,843 bp
  • A to G, chromosome 1 at 71,586,214 bp
  • A to G, chromosome 1 at 174,430,853 bp
  • GA to GAA, chromosome 2 at 90,917,709 bp
  • C to T, chromosome 2 at 151,706,419 bp
  • C to T, chromosome 3 at 59,248,651 bp
  • T to C, chromosome 3 at 133,116,465 bp
  • A to G, chromosome 4 at 4,069,908 bp
  • A to G, chromosome 4 at 22,487,536 bp
  • A to T, chromosome 4 at 61,832,634 bp
  • A to T, chromosome 4 at 88,423,027 bp
  • T to C, chromosome 4 at 101,782,596 bp
  • A to G, chromosome 4 at 101,909,164 bp
  • A to T, chromosome 5 at 3,664,343 bp
  • C to T, chromosome 6 at 8,175,534 bp
  • T to A, chromosome 6 at 47,904,599 bp
  • T to A, chromosome 6 at 89,650,561 bp
  • G to A, chromosome 6 at 125,590,227 bp
  • C to T, chromosome 7 at 44,880,380 bp
  • A to G, chromosome 7 at 104,180,291 bp
  • G to A, chromosome 7 at 108,937,817 bp
  • T to A, chromosome 7 at 133,725,272 bp
  • ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC to ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC, chromosome 7 at 142,082,067 bp
  • T to C, chromosome 8 at 122,864,337 bp
  • T to A, chromosome 8 at 124,731,872 bp
  • T to C, chromosome 9 at 53,912,774 bp
  • A to G, chromosome 9 at 105,022,401 bp
  • A to G, chromosome 9 at 107,677,439 bp
  • C to T, chromosome 10 at 43,882,081 bp
  • T to A, chromosome 10 at 62,963,823 bp
  • A to G, chromosome 11 at 6,518,987 bp
  • G to A, chromosome 11 at 98,896,315 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • A to G, chromosome 12 at 72,178,544 bp
  • A to G, chromosome 12 at 84,760,718 bp
  • A to T, chromosome 12 at 111,313,353 bp
  • T to A, chromosome 13 at 22,395,454 bp
  • T to C, chromosome 13 at 50,702,396 bp
  • C to A, chromosome 13 at 59,717,518 bp
  • G to A, chromosome 14 at 20,439,654 bp
  • C to A, chromosome 14 at 58,893,945 bp
  • T to C, chromosome 14 at 75,995,445 bp
  • A to G, chromosome 15 at 12,371,639 bp
  • T to C, chromosome 15 at 27,664,549 bp
  • T to C, chromosome 15 at 34,509,809 bp
  • T to C, chromosome 15 at 76,751,559 bp
  • A to G, chromosome 16 at 38,522,428 bp
  • T to A, chromosome 17 at 24,983,177 bp
  • A to G, chromosome 17 at 52,803,484 bp
  • A to T, chromosome 17 at 67,042,318 bp
  • T to A, chromosome 18 at 14,821,473 bp
  • G to A, chromosome 18 at 20,086,635 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1054 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039144-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.