Strain Name:
C57BL/6J-MtgxR1120Btlr/Mmmh
Stock Number:
039193-MU
Citation ID:
RRID:MMRRC_039193-MU
Other Names:
R1120 (G1), C57BL/6J-MtgxR1120Btlr
Major Collection:

Strain Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Cd36
Name: CD36 molecule
Synonyms: FAT, fatty acid translocase, Scarb3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Eef1e1
Name: eukaryotic translation elongation factor 1 epsilon 1
Synonyms: 1110003A02Rik, AIMP3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66143
VEGA: 13
HGNC: HGNC:3212
Homologene: 3161
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77626
Homologene: 9813
Fnbp1
Name: formin binding protein 1
Synonyms: FBP1, FBP17, 2210010H06Rik, 1110057E06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14269
Homologene: 100983
Crhbp
Name: corticotropin releasing hormone binding protein
Synonyms: CRH-BP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12919
VEGA: 13
HGNC: HGNC:2356
Homologene: 1418
Rab5b
Name: RAB5B, member RAS oncogene family
Synonyms: C030027M18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19344
VEGA: 10
HGNC: HGNC:9784
Homologene: 104027
Abcb8
Name: ATP-binding cassette, sub-family B member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Cd2
Name: CD2 antigen
Synonyms: LFA-2, Ly37, Ly-37
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12481
HGNC: HGNC:1639
Homologene: 1338
Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Synonyms: SNF5/INI1, integrase interactor 1, Baf47, Ini1, Snf5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20587
Homologene: 2310
Ubb
Name: ubiquitin B
Synonyms: Ubb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22187
Homologene: 74981
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: 6330415L08Rik, IRAK-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Or4c109
Name: olfactory receptor family 4 subfamily C member 109
Synonyms: GA_x6K02T2Q125-50468705-50467770, MOR233-8, Olfr1214
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258899
Homologene: 73984
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Samd5
Name: sterile alpha motif domain containing 5
Synonyms: E130306M17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320825
Homologene: 37106
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Fxyd3
Name: FXYD domain-containing ion transport regulator 3
Synonyms: Mat8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17178
HGNC: HGNC:4027
Homologene: 4356
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: 1600029O10Rik, collaborator of Stat6, CoaSt6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 547253
Homologene: 19697
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: GA_x6K02T2Q125-50202854-50201910, MOR225-10P, MOR225-14, Olfr1197
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11648
Homologene: 134333
Trmu
Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Synonyms: 1600025P05Rik, 1110005N20Rik, Trmt1, Mtu1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72026
Homologene: 5589
Jpt2
Name: Jupiter microtubule associated homolog 2
Synonyms: 2810430B18Rik, D17Ertd441e, Hn1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52009
VEGA: 17
Homologene: 16934
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Tnfrsf26
Name: tumor necrosis factor receptor superfamily, member 26
Synonyms: Tnfrh3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244237
Homologene: 52188
Or9k2
Name: olfactory receptor family 9 subfamily K member 2
Synonyms: GA_x6K02T2PULF-11834065-11833103, MOR210-1, Olfr825
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258672
Homologene: 121503
Krtap8-1
Name: keratin associated protein 8-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16703
VEGA: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,452,581 bp
  • A to G, chromosome 1 at 44,161,841 bp
  • A to G, chromosome 1 at 75,258,181 bp
  • A to T, chromosome 1 at 87,125,437 bp
  • T to C, chromosome 1 at 183,098,575 bp
  • T to A, chromosome 2 at 20,806,703 bp
  • A to T, chromosome 2 at 31,036,594 bp
  • A to G, chromosome 2 at 88,728,937 bp
  • A to G, chromosome 2 at 88,988,079 bp
  • A to G, chromosome 2 at 119,062,375 bp
  • A to T, chromosome 3 at 86,295,192 bp
  • C to T, chromosome 3 at 101,287,488 bp
  • A to G, chromosome 5 at 17,785,828 bp
  • T to G, chromosome 5 at 24,408,820 bp
  • A to T, chromosome 5 at 106,904,218 bp
  • T to C, chromosome 6 at 23,838,794 bp
  • G to T, chromosome 6 at 38,194,770 bp
  • T to A, chromosome 6 at 113,675,759 bp
  • A to G, chromosome 7 at 31,071,378 bp
  • A to G, chromosome 7 at 80,481,466 bp
  • T to A, chromosome 7 at 102,160,716 bp
  • G to A, chromosome 7 at 143,617,914 bp
  • A to G, chromosome 10 at 9,629,048 bp
  • A to G, chromosome 10 at 75,725,716 bp
  • A to G, chromosome 10 at 75,921,323 bp
  • A to C, chromosome 10 at 128,679,614 bp
  • A to G, chromosome 10 at 130,162,537 bp
  • T to C, chromosome 11 at 62,552,183 bp
  • T to A, chromosome 11 at 87,538,676 bp
  • C to T, chromosome 11 at 115,815,013 bp
  • A to G, chromosome 12 at 44,304,947 bp
  • A to T, chromosome 13 at 38,658,934 bp
  • G to T, chromosome 13 at 95,442,085 bp
  • A to G, chromosome 15 at 85,890,285 bp
  • T to C, chromosome 16 at 17,638,486 bp
  • G to A, chromosome 16 at 35,856,760 bp
  • A to G, chromosome 16 at 89,487,865 bp
  • A to T, chromosome 17 at 19,577,461 bp
  • T to C, chromosome 17 at 24,960,611 bp
  • A to T, chromosome 17 at 71,358,146 bp
  • A to G, chromosome 18 at 19,986,977 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1120 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039193-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.