Strain Name:
C57BL/6J-MtgxR1395Btlr/Mmmh
Stock Number:
039457-MU
Citation ID:
RRID:MMRRC_039457-MU
Other Names:
R1395 (G1), C57BL/6J-MtgxR1395Btlr
Major Collection:

Strain Information

Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Nf1
Name: neurofibromin 1
Synonyms: Mhdadsk9, neurofibromin, Nf-1, Dsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Wdr44
Name: WD repeat domain 44
Synonyms: RAB11BP, DKFZp686L20145, RPH11, 2610034K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 72404
Homologene: 56839
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Cep128
Name: centrosomal protein 128
Synonyms: 4930534B04Rik, 5430424K18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75216
Homologene: 35315
Psen1
Name: presenilin 1
Synonyms: PS1, Ad3h, S182, PS-1, presenilin-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19164
VEGA: 12
HGNC: HGNC:9508
Homologene: 7186
Mlh1
Name: mutL homolog 1
Synonyms: colon cancer, nonpolyposis type 2, 1110035C23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17350
HGNC: HGNC:7127
Homologene: 208
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74741
Homologene: 8873
Eef1a1
Name: eukaryotic translation elongation factor 1 alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13627
HGNC: HGNC:3189
Homologene: 100799
Ift81
Name: intraflagellar transport 81
Synonyms: CDV-1R, Cdv1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12589
Homologene: 7664
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ift172
Name: intraflagellar transport 172
Synonyms: 4930553F24Rik, wim, avc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67661
Homologene: 15202
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272636
Homologene: 18626
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: arrestin 1, Arr1, A930001K18Rik, rod arrestin, visual arrestin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20215
Homologene: 455
Tub
Name: TUB bipartite transcription factor
Synonyms: tub, rd5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22141
Homologene: 31147
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233208
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 211223
Homologene: 129606
Or51ah3
Name: olfactory receptor family 51 subfamily AH member 3
Synonyms: MOR19-2, Olfr615, GA_x6K02T2PBJ9-6284902-6285843
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259084
Homologene: 17494
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms: GluR-A, Glur-1, Glur1, 2900051M01Rik, GluA1, Glr1, GluR1, HIPA1, Glr-1, GluRA
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14799
HGNC: HGNC:4571
Homologene: 20226
Spata46
Name: spermatogenesis associated 46
Synonyms: 1700015E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76925
Homologene: 18799
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Synonyms: Ugt3a, Ugt3a1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105887
Homologene: 122787
Rgma
Name: repulsive guidance molecule family member A
Synonyms: RGM domain family, member A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244058
Homologene: 10626
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Synonyms: Map1lc3, Atg8, LC3b, 1010001C15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67443
Homologene: 69359
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Or6z6
Name: olfactory receptor family 6 subfamily Z member 6
Synonyms: MOR103-11, GA_x6K02T2QGBW-3218686-3217748, MOR103-19_i, Olfr1347
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258383
Homologene: 128065
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98733
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: Gm597, LOC210962
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216613
Homologene: 65605
Drgx
Name: dorsal root ganglia homeobox
Synonyms: Prrxl1, Drg11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 107751
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: protein-glutamine gamma-glutamyltransferase, TGase2, TG2, tissue transglutaminase, tTGas, tTG, TG C, G[a]h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21817
Homologene: 3391
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 4432406M01Rik, 1110034E15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Zfp663
Name: zinc finger protein 663
Synonyms: LOC381405, Gm1008
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381405
Homologene: 128277
Fdxacb1
Name: ferredoxin-fold anticodon binding domain containing 1
Synonyms: D630004A14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382137
Homologene: 19813
Rdh12
Name: retinol dehydrogenase 12
Synonyms: A930033N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77974
Homologene: 110830
Or51f23
Name: olfactory receptor family 51 subfamily F member 23
Synonyms: GA_x6K02T2PBJ9-5513635-5514627, MOR14-10, Olfr564
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258356
Homologene: 121507
Or9s13
Name: olfactory receptor family 9 subfamily S member 13
Synonyms: MOR208-5, GA_x6K02T2R7CC-81134096-81133095, Olfr12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 257890
Homologene: 114777
A330070K13Rik
Name: RIKEN cDNA A330070K13 gene
Synonyms: LOC381673
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381673
Klrb1b
Name: killer cell lectin-like receptor subfamily B member 1B
Synonyms: Ly55b, NKR-P1D, Ly55d, NKR-P1B, Nkrp1-b, Nkrp1d, Klrb1d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80782
HGNC: HGNC:6373
Homologene: 84369
Nkain2
Name: Na+/K+ transporting ATPase interacting 2
Synonyms: Tcba1, 6330571D19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432450
Homologene: 65073
Zfp322a
Name: zinc finger protein 322A
Synonyms: 9630054P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218100
Homologene: 23460
Gm8374
Name: predicted gene 8374
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 28,776,809 bp
  • C to T, chromosome 1 at 54,417,778 bp
  • T to C, chromosome 1 at 75,492,665 bp
  • G to A, chromosome 1 at 87,828,441 bp
  • T to A, chromosome 1 at 92,620,545 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • T to C, chromosome 1 at 106,350,618 bp
  • A to G, chromosome 1 at 170,312,004 bp
  • A to G, chromosome 2 at 62,313,286 bp
  • C to T, chromosome 2 at 113,833,122 bp
  • C to T, chromosome 2 at 121,303,925 bp
  • T to G, chromosome 2 at 146,388,500 bp
  • T to A, chromosome 2 at 158,124,252 bp
  • T to C, chromosome 2 at 165,352,572 bp
  • T to A, chromosome 2 at 180,998,607 bp
  • A to G, chromosome 4 at 51,228,366 bp
  • T to C, chromosome 5 at 31,285,238 bp
  • T to C, chromosome 5 at 73,072,912 bp
  • T to A, chromosome 5 at 109,294,148 bp
  • A to G, chromosome 5 at 113,101,496 bp
  • T to C, chromosome 5 at 121,328,513 bp
  • G to T, chromosome 5 at 122,568,923 bp
  • A to G, chromosome 5 at 130,379,141 bp
  • G to A, chromosome 6 at 128,820,330 bp
  • T to C, chromosome 6 at 143,061,738 bp
  • T to A, chromosome 7 at 6,488,362 bp
  • A to G, chromosome 7 at 28,093,379 bp
  • T to A, chromosome 7 at 29,531,387 bp
  • T to C, chromosome 7 at 35,615,869 bp
  • T to C, chromosome 7 at 45,008,297 bp
  • G to T, chromosome 7 at 73,417,794 bp
  • G to A, chromosome 7 at 102,804,207 bp
  • T to C, chromosome 7 at 103,561,119 bp
  • C to T, chromosome 7 at 109,020,954 bp
  • G to T, chromosome 8 at 120,574,999 bp
  • T to C, chromosome 8 at 121,596,720 bp
  • C to T, chromosome 9 at 16,246,916 bp
  • T to C, chromosome 9 at 43,005,870 bp
  • TAGAC to T, chromosome 9 at 50,772,496 bp
  • T to C, chromosome 9 at 66,439,181 bp
  • T to C, chromosome 9 at 66,971,379 bp
  • C to T, chromosome 9 at 78,479,018 bp
  • T to C, chromosome 9 at 99,316,782 bp
  • T to C, chromosome 9 at 111,247,377 bp
  • C to A, chromosome 10 at 32,890,189 bp
  • T to C, chromosome 11 at 28,583,412 bp
  • T to C, chromosome 11 at 31,101,032 bp
  • T to A, chromosome 11 at 57,283,566 bp
  • T to C, chromosome 11 at 79,535,983 bp
  • A to G, chromosome 12 at 79,209,065 bp
  • G to A, chromosome 12 at 83,724,572 bp
  • C to T, chromosome 12 at 91,266,980 bp
  • C to T, chromosome 13 at 23,356,775 bp
  • G to T, chromosome 13 at 81,386,788 bp
  • G to T, chromosome 14 at 7,364,174 bp
  • T to A, chromosome 14 at 32,172,841 bp
  • C to T, chromosome 14 at 32,608,369 bp
  • A to G, chromosome 14 at 65,077,496 bp
  • T to G, chromosome 15 at 9,306,292 bp
  • A to G, chromosome 17 at 33,583,740 bp
  • T to C, chromosome 18 at 6,037,058 bp
  • A to G, chromosome 18 at 67,858,921 bp
  • T to C, chromosome 18 at 86,398,019 bp
  • A to G, chromosome 19 at 43,833,940 bp
  • T to G, chromosome X at 23,796,059 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1395 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039457-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.