Strain Name:
C57BL/6J-MtgxR1490Btlr/Mmmh
Stock Number:
039542-MU
Citation ID:
RRID:MMRRC_039542-MU
Other Names:
R1490 (G1), C57BL/6J-MtgxR1490Btlr
Major Collection:

Strain Information

Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Synonyms: CLIP, Ii
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16149
VEGA: 18
HGNC: HGNC:1697
Homologene: 3209
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Hpcal1
Name: hippocalcin-like 1
Synonyms: Nvp3, neural visinin-like 3, Vnsl3, visinin like 3, VILIP3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 53602
VEGA: 12
HGNC: HGNC:5145
Homologene: 37586
Comp
Name: cartilage oligomeric matrix protein
Synonyms: TSP5, thrombospondin-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: 4933403M19Rik, PKUalpha, protein kinase U-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Prgs, Gaps
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20540
Homologene: 88701
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: 3110039B05Rik, Bat-2, Bat2, G2, D17H6S51E, Wbp12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 9830127L17Rik, 2700078E11Rik, 2810417M16Rik, D130033C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78832
VEGA: 19
Homologene: 17821
Ppp3r1
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Synonyms: PP2B beta 1, CaNB1, Cnb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19058
HGNC: HGNC:9317
Homologene: 68099
Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Synonyms: Mal, Mal, wyatt, C130027E04Rik, MyD88-adapter-like
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 117149
Homologene: 14285
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Samd7
Name: sterile alpha motif domain containing 7
Synonyms: 4930597A01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75953
Homologene: 18802
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Tlr4
Name: toll-like receptor 4
Synonyms: Lps, lipopolysaccharide response, Rasl2-8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21898
Homologene: 41317
Zfp68
Name: zinc finger protein 68
Synonyms: KRAB3, Zfp68, Zfp70, KRAZ2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24135
Homologene: 56605
Mospd2
Name: motile sperm domain containing 2
Synonyms: 2410013I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 76763
Homologene: 22125
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Mtmr4
Name: myotubularin related protein 4
Synonyms: FYVE zinc finger phosphatase, ESTM44, ZFYVE11, FYVE-DSP2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: GCP3, Spc98p
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Dlx3
Name: distal-less homeobox 3
Synonyms: Dlx-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13393
HGNC: HGNC:2916
Homologene: 74544
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, Cd39l3, HB6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: D13Bwg1089e, Rho specific exchange factor, 9230110L08Rik, RIP2, Rgnef, p190RhoGEF, RhoGEF
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: Myhc-a, alpha cardiac MHC, Myhca, alphaMHC, alpha myosin, A830009F23Rik, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Tmem116
Name: transmembrane protein 116
Synonyms: 4930406A18Rik, 4930513P12Rik, C030022K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77462
Homologene: 12676
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, GlcT-1, Epcs21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22234
Homologene: 37763
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Eps8l1
Name: EPS8-like 1
Synonyms: DRC3, EPS8R1, 2310051G19Rik, 4632407K17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67425
Homologene: 15767
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Synonyms: Oct1, Lx1, Oct1, Orct, Orct1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20517
VEGA: 17
Homologene: 20665
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227334
Homologene: 32400
Cfap95
Name: cilia and flagella associated protein 95
Synonyms: 1700028P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67483
VEGA: 19
Homologene: 49850
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: 4930568D07Rik, PFK-2/FBPase-2 gene B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239081
Homologene: 77905
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: 9330209L04Rik, Mamdc1, Adp, Mdga2, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Vmn1r61
Name: vomeronasal 1 receptor 61
Synonyms: Gm7186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 636731
Homologene: 41799
Or1e32
Name: olfactory receptor family 1 subfamily E member 32
Synonyms: GA_x6K02T2P1NL-3966976-3966038, MOR135-9, Olfr392
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259008
Homologene: 133580
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Sv2c
Name: synaptic vesicle glycoprotein 2c
Synonyms: 4930527L09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75209
Homologene: 57152
Or52e15
Name: olfactory receptor family 52 subfamily E member 15
Synonyms: Olfr672, MOR32-4, GA_x6K02T2PBJ9-7625746-7624808
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258755
Homologene: 138317
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, Psg24, EG384557
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
Or1o3
Name: olfactory receptor family 1 subfamily O member 3
Synonyms: MOR156-4, GA_x6K02T2PSCP-1703582-1702653, Olfr98
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258503
Homologene: 133051
Or2l13
Name: olfactory receptor family 2 subfamily L member 13
Synonyms: MOR270-1, GA_x54KRFPKG5P-15934912-15935850, Olfr166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259071
Homologene: 88350
Gm9875
Name: predicted gene 9875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 105244085
VEGA: 2
Ms4a19
Name: membrane-spanning 4-domains, subfamily A, member 19
Synonyms: 1700025F22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69416
Homologene: 137380
Gm10153
Name: predicted gene 10153
Type: Gene
Species: Mouse
Chromosome: 7
Dmrta2
Name: doublesex and mab-3 related transcription factor like family A2
Synonyms: Dmrt5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242620
Homologene: 100682
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Pfn3
Name: profilin 3
Synonyms: 1700012P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75477
VEGA: 13
Homologene: 12603
Cdip1
Name: cell death inducing Trp53 target 1
Synonyms: 5730403B10Rik, CDIP, 2700048O17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66626
Homologene: 40879
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,185,745 bp
  • G to A, chromosome 1 at 87,988,965 bp
  • A to C, chromosome 1 at 130,697,889 bp
  • C to T, chromosome 1 at 188,359,841 bp
  • T to C, chromosome 2 at 13,557,963 bp
  • T to C, chromosome 2 at 57,355,475 bp
  • A to G, chromosome 3 at 30,758,353 bp
  • A to G, chromosome 3 at 116,619,244 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • A to G, chromosome 4 at 59,719,746 bp
  • A to T, chromosome 4 at 66,839,374 bp
  • T to C, chromosome 4 at 109,979,875 bp
  • A to G, chromosome 4 at 145,537,283 bp
  • T to C, chromosome 5 at 121,495,111 bp
  • A to T, chromosome 5 at 138,606,829 bp
  • A to G, chromosome 7 at 4,470,889 bp
  • T to C, chromosome 7 at 5,611,243 bp
  • A to G, chromosome 7 at 17,163,146 bp
  • A to G, chromosome 7 at 104,996,493 bp
  • T to A, chromosome 7 at 127,343,631 bp
  • C to T, chromosome 7 at 142,190,142 bp
  • A to T, chromosome 8 at 12,639,550 bp
  • A to G, chromosome 8 at 70,373,913 bp
  • A to T, chromosome 8 at 104,622,070 bp
  • ACTGCTGCTGCTGCTGCTG to ACTGCTGCTGCTGCTG, chromosome 9 at 35,189,066 bp
  • T to C, chromosome 9 at 45,918,941 bp
  • A to G, chromosome 9 at 108,113,994 bp
  • T to C, chromosome 9 at 109,027,620 bp
  • A to G, chromosome 9 at 120,554,159 bp
  • G to A, chromosome 10 at 83,520,370 bp
  • A to G, chromosome 10 at 92,700,798 bp
  • A to G, chromosome 11 at 17,198,275 bp
  • A to G, chromosome 11 at 73,814,371 bp
  • G to A, chromosome 11 at 87,612,225 bp
  • A to G, chromosome 11 at 87,862,769 bp
  • T to C, chromosome 11 at 95,120,604 bp
  • T to A, chromosome 11 at 105,267,254 bp
  • A to T, chromosome 12 at 17,786,224 bp
  • T to C, chromosome 12 at 66,797,756 bp
  • A to G, chromosome 13 at 23,904,753 bp
  • T to G, chromosome 13 at 55,414,919 bp
  • G to A, chromosome 13 at 67,257,509 bp
  • A to G, chromosome 13 at 95,989,194 bp
  • G to A, chromosome 13 at 97,978,444 bp
  • C to A, chromosome 14 at 33,152,538 bp
  • A to C, chromosome 14 at 50,363,176 bp
  • C to T, chromosome 14 at 54,408,646 bp
  • T to A, chromosome 14 at 54,962,718 bp
  • C to T, chromosome 16 at 4,768,911 bp
  • C to A, chromosome 16 at 17,386,268 bp
  • T to C, chromosome 16 at 19,486,922 bp
  • A to T, chromosome 16 at 91,624,344 bp
  • A to T, chromosome 17 at 12,662,893 bp
  • A to G, chromosome 17 at 35,153,254 bp
  • A to G, chromosome 17 at 37,262,842 bp
  • A to T, chromosome 17 at 80,413,675 bp
  • G to A, chromosome 17 at 84,446,601 bp
  • A to G, chromosome 18 at 60,811,366 bp
  • A to G, chromosome 19 at 11,141,538 bp
  • A to G, chromosome 19 at 23,592,099 bp
  • G to T, chromosome 19 at 60,580,399 bp
  • GGAGAGAGAGAGAGAGAGAGAGAGAGAGA to GGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA, chromosome X at 164,944,177 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1490 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039542-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.