Strain Name:
C57BL/6J-MtgxR1726Btlr/Mmmh
Stock Number:
039758-MU
Citation ID:
RRID:MMRRC_039758-MU
Other Names:
R1726 (G1), C57BL/6J-MtgxR1726Btlr
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Synonyms: [b]2-nAchR, Acrb-2, Acrb2, C030030P04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11444
HGNC: HGNC:1962
Homologene: 595
Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67800
Homologene: 23580
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Pdxdc1
Name: pyridoxal-dependent decarboxylase domain containing 1
Synonyms: 2210010A19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94184
Homologene: 22858
Mrpl20
Name: mitochondrial ribosomal protein L20
Synonyms: 2610008D01Rik, 4930425I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66448
Homologene: 9941
Dvl2
Name: dishevelled segment polarity protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13543
HGNC: HGNC:3086
Homologene: 20927
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, F830021D11Rik, Uhrf1bp1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: Urb, Ssg1, 2610001E17Rik, DRO1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Ubtf
Name: upstream binding transcription factor, RNA polymerase I
Synonyms: UBF1, Tcfubf, UBF, A930005G04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21429
Homologene: 7970
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Ube2c
Name: ubiquitin-conjugating enzyme E2C
Synonyms: 1110015A16Rik, D2Ertd695e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68612
Homologene: 5096
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, Iir, 5330417C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229722
Homologene: 23249
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Btf3
Name: basic transcription factor 3
Synonyms: 1700054E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218490
HGNC: HGNC:1125
Homologene: 37453
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: 2810403P18Rik, Grim-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72171
Homologene: 31683
Pias4
Name: protein inhibitor of activated STAT 4
Synonyms: PIASy
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59004
Homologene: 104136
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: BACH1, 8030460J03Rik, 3110009N10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237911
Homologene: 32766
Mtmr9
Name: myotubularin related protein 9
Synonyms: mMTMH3, LIP-STYX, MTMR8, 9430075G12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210376
VEGA: 14
Homologene: 9148
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, TFIIIC-BETA, TFIIIC110, 1300004C11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Olig3
Name: oligodendrocyte transcription factor 3
Synonyms: Bhlhb7, bHLHe20
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94222
VEGA: 10
Homologene: 14201
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Mob3b
Name: MOB kinase activator 3B
Synonyms: MOB3B, A430018A01Rik, 8430436F23Rik, Mobkl2b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214944
Homologene: 69385
Zkscan2
Name: zinc finger with KRAB and SCAN domains 2
Synonyms: 9430065N20Rik, Zfp694
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210162
Homologene: 19671
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 333669
Homologene: 129891
Pcyox1l
Name: prenylcysteine oxidase 1 like
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240334
Homologene: 23429
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: GA_x6K02T2PMLR-6224293-6225228, MOR106-6, Olfr742
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239081
Homologene: 77905
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
Nemp2
Name: nuclear envelope integral membrane protein 2
Synonyms: 5330401P04Rik, Tmem194b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227094
Homologene: 67089
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, PcdhbN, 2210006M07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Or5e1
Name: olfactory receptor family 5 subfamily E member 1
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1, Olfr513
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258718
Homologene: 64908
Smg8
Name: SMG8 nonsense mediated mRNA decay factor
Synonyms: 1200011M11Rik, smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74133
Homologene: 32393
Ccl11
Name: C-C motif chemokine ligand 11
Synonyms: eotaxin, Scya11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20292
Homologene: 7929
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216961
Homologene: 104099
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229688
Homologene: 77638
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Or10j5
Name: olfactory receptor family 10 subfamily J member 5
Synonyms: MOR23, MOR267-13, GA_x6K02T2R7CC-893157-892228, Olfr16
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18313
Homologene: 7460
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74121
Homologene: 75083
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Insyn2a
Name: inhibitory synaptic factor 2A
Synonyms: B830028B13Rik, Fam196a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 627214
Homologene: 85469
Slc26a1
Name: solute carrier family 26 (sulfate transporter), member 1
Synonyms: Sat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231583
Homologene: 32539
Psmc3
Name: proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms: Tat binding protein 1, TBP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19182
HGNC: HGNC:9549
Homologene: 2097
Mrpl1
Name: mitochondrial ribosomal protein L1
Synonyms: 2410002L03Rik, 5830418D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94061
Homologene: 41355
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Helios, Zfpn1a2, A730095J18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22779
Homologene: 22659
Reep6
Name: receptor accessory protein 6
Synonyms: Dp1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70335
Homologene: 133833
Gm2663
Name: predicted gene 2663
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100040208
Homologene: 117995
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Gm15409
Name: predicted gene 15409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Gm10277
Name: predicted gene 10277
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 791303
Gm10762
Name: predicted gene 10762
Type: Gene
Species: Mouse
Chromosome: 2
Galt
Name: galactose-1-phosphate uridyl transferase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14430
HGNC: HGNC:4135
Homologene: 126
Mrpl57
Name: mitochondrial ribosomal protein L57
Synonyms: 2610025P17Rik, Mrp63
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67840
VEGA: 14
Homologene: 11422
Slc14a1
Name: solute carrier family 14 (urea transporter), member 1
Synonyms: 2610507K20Rik, UT-B, 3021401A05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108052
Homologene: 9285
AC147549.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,637,395 bp
  • C to A, chromosome 1 at 69,548,688 bp
  • A to G, chromosome 1 at 172,957,091 bp
  • A to G, chromosome 2 at 77,108,356 bp
  • C to A, chromosome 2 at 91,059,140 bp
  • T to A, chromosome 2 at 112,347,426 bp
  • G to A, chromosome 2 at 127,880,446 bp
  • A to T, chromosome 2 at 128,967,215 bp
  • G to T, chromosome 2 at 164,771,317 bp
  • A to T, chromosome 3 at 89,761,202 bp
  • T to C, chromosome 3 at 106,389,843 bp
  • A to G, chromosome 3 at 108,467,868 bp
  • A to G, chromosome 3 at 141,818,103 bp
  • A to G, chromosome 4 at 34,954,028 bp
  • G to A, chromosome 4 at 41,756,001 bp
  • G to T, chromosome 4 at 155,803,753 bp
  • C to T, chromosome 5 at 25,315,005 bp
  • T to C, chromosome 5 at 31,169,123 bp
  • T to C, chromosome 5 at 96,223,827 bp
  • C to T, chromosome 5 at 108,673,675 bp
  • C to A, chromosome 5 at 148,959,501 bp
  • T to C, chromosome 6 at 40,998,026 bp
  • T to C, chromosome 6 at 100,637,035 bp
  • A to G, chromosome 7 at 99,182,416 bp
  • T to C, chromosome 7 at 108,755,008 bp
  • T to A, chromosome 7 at 123,489,823 bp
  • T to C, chromosome 7 at 134,899,138 bp
  • A to T, chromosome 8 at 3,454,228 bp
  • A to G, chromosome 10 at 19,356,734 bp
  • G to A, chromosome 10 at 53,537,881 bp
  • C to A, chromosome 10 at 75,992,527 bp
  • T to C, chromosome 10 at 80,335,120 bp
  • A to C, chromosome 10 at 81,155,855 bp
  • A to T, chromosome 11 at 69,497,889 bp
  • A to T, chromosome 11 at 70,009,461 bp
  • C to A, chromosome 11 at 77,467,738 bp
  • TC to T, chromosome 11 at 77,786,002 bp
  • A to G, chromosome 11 at 82,061,720 bp
  • A to T, chromosome 11 at 86,064,914 bp
  • G to T, chromosome 11 at 87,080,613 bp
  • A to G, chromosome 11 at 97,224,669 bp
  • A to G, chromosome 11 at 102,310,917 bp
  • A to G, chromosome 11 at 116,145,454 bp
  • G to C, chromosome 12 at 118,874,801 bp
  • A to T, chromosome 12 at 118,907,532 bp
  • A to G, chromosome 13 at 9,575,428 bp
  • A to T, chromosome 13 at 23,905,591 bp
  • T to A, chromosome 13 at 32,729,169 bp
  • A to T, chromosome 13 at 67,474,720 bp
  • C to T, chromosome 13 at 98,316,296 bp
  • A to T, chromosome 14 at 50,361,541 bp
  • T to A, chromosome 14 at 50,516,179 bp
  • T to C, chromosome 14 at 54,469,656 bp
  • A to G, chromosome 14 at 57,826,635 bp
  • A to G, chromosome 14 at 63,537,098 bp
  • A to T, chromosome 14 at 123,308,404 bp
  • A to G, chromosome 15 at 89,557,986 bp
  • A to C, chromosome 16 at 13,838,300 bp
  • A to T, chromosome 16 at 45,096,005 bp
  • C to T, chromosome 17 at 24,564,176 bp
  • T to A, chromosome 17 at 27,111,690 bp
  • C to A, chromosome 17 at 27,886,251 bp
  • T to A, chromosome 17 at 36,015,621 bp
  • T to C, chromosome 17 at 67,042,327 bp
  • C to A, chromosome 18 at 21,148,262 bp
  • T to A, chromosome 18 at 37,449,594 bp
  • T to C, chromosome 18 at 61,697,778 bp
  • T to A, chromosome 18 at 78,116,466 bp
  • A to G, chromosome Y at 10,616,358 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1726 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039758-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.