Strain Name:
C57BL/6J-MtgxR2076Btlr/Mmmh
Stock Number:
040081-MU
Citation ID:
RRID:MMRRC_040081-MU
Other Names:
R2076 (G1), C57BL/6J-MtgxR2076Btlr
Major Collection:

Strain Information

Mrtfb
Name: myocardin related transcription factor B
Synonyms: Mrtfb, Mkl2, MRTF-B, Gt4-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239719
Homologene: 40917
Ccne2
Name: cyclin E2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: 1200015E08Rik, D13Ertd524e, Lgals-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Myo1e
Name: myosin IE
Synonyms: 9130023P14Rik, 2310020N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: ubiquitin activating enzyme 3, Ube1c, A830034N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22200
Homologene: 2951
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: Enx-1, KMT6, Enx1h
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Spast
Name: spastin
Synonyms: Spg4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50850
VEGA: 17
Homologene: 8970
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: Grf2, 4932418O06Rik, C3G
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Klhl24
Name: kelch-like 24
Synonyms: 1110046J11Rik, 6530402O20Rik, 4930429H24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75785
VEGA: 16
Homologene: 32352
Cct7
Name: chaperonin containing TCP1 subunit 7
Synonyms: Cctz, Ccth
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Dlx6
Name: distal-less homeobox 6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13396
HGNC: HGNC:2919
Homologene: 87855
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Zfp180
Name: zinc finger protein 180
Synonyms: HHZ168, D130011P11, 2310040I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Csn2
Name: casein beta
Synonyms: CSN2, Csnb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12991
HGNC: HGNC:2447
Homologene: 1426
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Crb3
Name: crumbs family member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224912
Homologene: 134352
Rad52
Name: RAD52 homolog, DNA repair protein
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19365
HGNC: HGNC:9824
Homologene: 31118
F11r
Name: F11 receptor
Synonyms: Ly106, JAM-A, JAM-1, ESTM33, BV11 antigen, Jcam1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16456
Homologene: 14255
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, Dby, 8030469F12Rik
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Zfp655
Name: zinc finger protein 655
Synonyms: 2700038I16Rik, 9030409O18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72611
Homologene: 12473
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: Ccdc64, 2210403N09Rik, BICDR-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75665
Homologene: 18013
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, 2410089E03Rik, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Fip200, 2900055E04Rik, 5930404L04Rik, Cc1, LaXp180
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 270893
Homologene: 41524
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16578
Homologene: 65620
Apba1
Name: amyloid beta precursor protein binding family A member 1
Synonyms: Lin-10, X11alpha, 6430513E09Rik, X11, Mint, Mint1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319924
VEGA: 19
HGNC: HGNC:578
Homologene: 897
Irf2
Name: interferon regulatory factor 2
Synonyms: Irf-2, 9830146E22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16363
HGNC: HGNC:6117
Homologene: 1659
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Shoc1
Name: shortage in chiasmata 1
Synonyms: LOC242489, Gm426, AI481877, Mzip2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100155
Homologene: 79783
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist, Egfr-rs, Dist1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: B930033A02Rik, ABC13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Themis2
Name: thymocyte selection associated family member 2
Synonyms: BC013712, ICB-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230787
Homologene: 21009
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Zfp518a
Name: zinc finger protein 518A
Synonyms: Zfp518, 2810401C22Rik, 6330417C12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Ces2h
Name: carboxylesterase 2H
Synonyms: Gm5744
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 436059
HGNC: HGNC:1864
Homologene: 128645
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69504
Homologene: 137770
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: ORP5, Obph1, 1110006M06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79196
Homologene: 98024
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: 2010309H15Rik, Thea, BFIT1, Them1, 1110020M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329910
Homologene: 11977
Vmn1r230
Name: vomeronasal 1 receptor 230
Synonyms: V1re8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171231
Homologene: 136306
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: 9530008N10Rik, experimental autoimmune prostatitis antigen 1, Eapa1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: Cyp3a, Pcn, IIIAm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230612
Homologene: 17081
Frat2
Name: frequently rearranged in advanced T cell lymphomas 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 212398
Homologene: 8095
Dipk1c
Name: divergent protein kinase domain 1C
Synonyms: Fam69c, B230399E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240479
Homologene: 45477
Dlgap1
Name: DLG associated protein 1
Synonyms: 4933422O14Rik, GKAP/SAPAP, D17Bwg0511e, SAPAP1, DAP-1 beta, Gkap, Sapap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: TOAD-64, Ulip2, Crmp2, DRP2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
RP23-208E23.3
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22784
Homologene: 74470
Ccdc159
Name: coiled-coil domain containing 159
Synonyms: 2510048L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67119
VEGA: 9
Homologene: 12084
Cd3g
Name: CD3 antigen, gamma polypeptide
Synonyms: T3g, Ctg-3, Ctg3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12502
HGNC: HGNC:1675
Homologene: 55
Gm6034
Name: predicted gene 6034
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547347
Npw
Name: neuropeptide W
Synonyms: LOC381073
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381073
Homologene: 17727
Ift25
Name: intraflagellar transport 25
Synonyms: 2900042B11Rik, Hspb11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72938
Homologene: 22947
AC113533.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,250,038 bp
  • T to G, chromosome 1 at 46,242,321 bp
  • T to C, chromosome 1 at 53,503,809 bp
  • T to A, chromosome 1 at 171,462,878 bp
  • A to G, chromosome 2 at 29,702,508 bp
  • T to A, chromosome 2 at 112,334,356 bp
  • A to G, chromosome 4 at 11,197,177 bp
  • T to C, chromosome 4 at 56,786,620 bp
  • A to G, chromosome 4 at 59,082,410 bp
  • T to C, chromosome 4 at 106,770,713 bp
  • T to C, chromosome 4 at 107,279,767 bp
  • T to C, chromosome 4 at 111,885,573 bp
  • T to C, chromosome 4 at 132,785,802 bp
  • G to T, chromosome 5 at 31,086,821 bp
  • A to G, chromosome 5 at 87,696,174 bp
  • A to G, chromosome 5 at 110,009,468 bp
  • A to T, chromosome 5 at 115,655,928 bp
  • A to G, chromosome 5 at 138,821,267 bp
  • A to G, chromosome 5 at 145,244,600 bp
  • A to T, chromosome 5 at 145,879,766 bp
  • A to G, chromosome 6 at 6,867,098 bp
  • G to A, chromosome 6 at 29,205,163 bp
  • A to T, chromosome 6 at 47,576,633 bp
  • A to T, chromosome 6 at 85,468,140 bp
  • G to T, chromosome 6 at 97,199,280 bp
  • C to T, chromosome 6 at 119,911,079 bp
  • A to G, chromosome 7 at 24,105,103 bp
  • A to G, chromosome 7 at 81,308,945 bp
  • T to C, chromosome 7 at 143,709,144 bp
  • G to T, chromosome 8 at 46,845,927 bp
  • T to C, chromosome 8 at 105,019,028 bp
  • T to C, chromosome 9 at 21,929,506 bp
  • T to A, chromosome 9 at 44,974,297 bp
  • T to A, chromosome 9 at 70,383,877 bp
  • A to C, chromosome 9 at 101,144,371 bp
  • T to A, chromosome 9 at 110,485,032 bp
  • G to T, chromosome 9 at 123,051,095 bp
  • C to G, chromosome 10 at 5,040,897 bp
  • T to A, chromosome 10 at 28,589,368 bp
  • T to C, chromosome 10 at 74,342,647 bp
  • T to C, chromosome 11 at 32,214,088 bp
  • T to A, chromosome 11 at 82,435,068 bp
  • A to T, chromosome 11 at 110,287,652 bp
  • C to T, chromosome 12 at 9,024,281 bp
  • T to A, chromosome 13 at 12,454,869 bp
  • G to A, chromosome 13 at 42,164,393 bp
  • A to G, chromosome 13 at 73,268,265 bp
  • A to G, chromosome 14 at 66,865,122 bp
  • T to A, chromosome 15 at 8,219,257 bp
  • T to C, chromosome 15 at 8,311,207 bp
  • T to A, chromosome 15 at 71,478,243 bp
  • C to T, chromosome 15 at 89,158,026 bp
  • T to C, chromosome 16 at 13,401,382 bp
  • T to C, chromosome 16 at 20,117,878 bp
  • C to A, chromosome 16 at 20,186,282 bp
  • T to A, chromosome 16 at 34,332,143 bp
  • T to A, chromosome 17 at 20,846,882 bp
  • A to T, chromosome 17 at 24,657,439 bp
  • A to G, chromosome 17 at 36,056,469 bp
  • G to A, chromosome 17 at 57,063,707 bp
  • C to T, chromosome 17 at 70,786,831 bp
  • G to C, chromosome 17 at 74,352,031 bp
  • G to T, chromosome 18 at 84,736,908 bp
  • G to T, chromosome 19 at 23,893,223 bp
  • T to C, chromosome 19 at 40,914,327 bp
  • T to C, chromosome 19 at 41,847,803 bp
  • A to G, chromosome Y at 1,266,593 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2076 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040081-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.