Strain Name:
C57BL/6J-MtgxR2078Btlr/Mmmh
Stock Number:
040083-MU
Citation ID:
RRID:MMRRC_040083-MU
Other Names:
R2078 (G1), C57BL/6J-MtgxR2078Btlr
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: myosin IIA, E030044M24Rik, NMHC II-A, Fltn, Myhn-1, Myhn1, D0Jmb2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Tomm20
Name: translocase of outer mitochondrial membrane 20
Synonyms: 1810060K07Rik, TOM20
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67952
Homologene: 44649
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224807
Homologene: 101682
Katna1
Name: katanin p60 (ATPase-containing) subunit A1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23924
HGNC: HGNC:6216
Homologene: 56014
Dlgap4
Name: DLG associated protein 4
Synonyms: DAP4, PSD-95/SAP90 binding protein 4, Sapap4, WBP16, SAP90/PSD-95-associated protein 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228836
Homologene: 8935
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, Sfrs8, 1190005N23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Ebag9
Name: estrogen receptor-binding fragment-associated gene 9
Synonyms: Rcas1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 55960
VEGA: 15
HGNC: HGNC:3123
Homologene: 3107
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Ezr
Name: ezrin
Synonyms: p81, Vil2, ezrin, cytovillin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22350
Homologene: 55740
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, 2810406C15Rik, CNAP1, 2810465G24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75734
Homologene: 87000
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Gas2
Name: growth arrest specific 2
Synonyms: Gas-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14453
HGNC: HGNC:4167
Homologene: 31301
Gper1
Name: G protein-coupled estrogen receptor 1
Synonyms: CMKRL2, Gpr30, 6330420K13Rik, Gper, GPCR-Br, Ceprl, FEG-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76854
HGNC: HGNC:4485
Homologene: 15855
Neurod6
Name: neurogenic differentiation 6
Synonyms: Math-2, Nex, Math2, Nex1m, Atoh2, bHLHa2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11922
Homologene: 7632
Ncr1
Name: natural cytotoxicity triggering receptor 1
Synonyms: NKp46, Ly94, MAR1 (mouse activating receptor 1), Cd335
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17086
HGNC: HGNC:6731
Homologene: 3551
Gda
Name: guanine deaminase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14544
HGNC: HGNC:4212
Homologene: 3171
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana2, Mana-2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Pafah1b2
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
Synonyms: PAF-AH 30, mus[b], Pafahb, PAF-AH alpha2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18475
VEGA: 9
HGNC: HGNC:8575
Homologene: 1932
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72946
Homologene: 10795
Terf2ip
Name: telomeric repeat binding factor 2, interacting protein
Synonyms: Rap1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57321
Homologene: 10357
Abcb6
Name: ATP-binding cassette, sub-family B member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: 9430031J16Rik, Jr6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241134
Homologene: 18239
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: 8430416H19Rik, LOC380660
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380660
Homologene: 11587
Atxn7
Name: ataxin 7
Synonyms: A430107N12Rik, ataxin-7, Sca7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 246103
VEGA: 14
Homologene: 30967
Vsig8
Name: V-set and immunoglobulin domain containing 8
Synonyms: EG240916
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240916
Homologene: 18616
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Fam38b
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242594
Homologene: 52981
Itga1
Name: integrin alpha 1
Synonyms: Vla1, CD49A, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, 4732433M03Rik, CPSase I, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Nyk, Tyro 12, Mer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67608
Homologene: 57048
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
4832428D23Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Tspan33
Name: tetraspanin 33
Synonyms: Penumbra, 1300010A20Rik, Pen
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232670
Homologene: 8213
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2y1r, P2Y1 receptor, P2Y1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: C230004D03Rik, Rsbp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229675
Homologene: 10154
Capn9
Name: calpain 9
Synonyms: nCL-4, GC36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73647
HGNC: HGNC:1486
Homologene: 38208
Or5b21
Name: olfactory receptor family 5 subfamily B member 21
Synonyms: MOR202-4, GA_x6K02T2RE5P-3191201-3192160, Olfr1444
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258697
Homologene: 64906
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Tmed5
Name: transmembrane p24 trafficking protein 5
Synonyms: 3110020O18Rik, 4432412D15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73130
Homologene: 4996
Slc38a11
Name: solute carrier family 38, member 11
Synonyms: 9330158F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320106
Homologene: 5775
Rnf150
Name: ring finger protein 150
Synonyms: C030044C12Rik, A630007N06Rik, Greul5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
Mtmr6
Name: myotubularin related protein 6
Synonyms: Gm38641, 4022440C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Lrfn3
Name: leucine rich repeat and fibronectin type III domain containing 3
Synonyms: A530045B06Rik, SALM4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233067
Homologene: 11558
Yipf7
Name: Yip1 domain family, member 7
Synonyms: Yip1b, 2310016N21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75581
Homologene: 69367
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15951
Homologene: 115929
Dusp6
Name: dual specificity phosphatase 6
Synonyms: 1300019I03Rik, PYST1, MKP3, MKP-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67603
VEGA: 10
HGNC: HGNC:3072
Homologene: 55621
Atp10d
Name: ATPase, class V, type 10D
Synonyms: 9830145H18Rik, D5Buc24e, IMAGE:1069176
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Fcrlb
Name: Fc receptor-like B
Synonyms: FREB2, Fcry, FcRL2, FREB-2, mFCRL2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435653
Homologene: 83202
Lce3c
Name: late cornified envelope 3C
Synonyms: Eig3, Sprrl1, 2300007B01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94060
Homologene: 137425
Rfc5
Name: replication factor C (activator 1) 5
Synonyms: Recc5, 2610020K06Rik, 36kDa, 36.5kDa, 2610209F07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72151
HGNC: HGNC:9973
Homologene: 6730
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 44,206,502 bp
  • T to G, chromosome 1 at 67,157,806 bp
  • T to C, chromosome 1 at 67,195,265 bp
  • C to A, chromosome 1 at 75,172,136 bp
  • T to C, chromosome 1 at 81,191,981 bp
  • T to C, chromosome 1 at 82,741,921 bp
  • C to G, chromosome 1 at 170,908,081 bp
  • C to A, chromosome 1 at 172,563,289 bp
  • T to C, chromosome 1 at 173,761,586 bp
  • A to T, chromosome 2 at 65,330,384 bp
  • C to T, chromosome 2 at 128,794,458 bp
  • T to C, chromosome 2 at 156,762,826 bp
  • A to G, chromosome 3 at 38,889,673 bp
  • A to G, chromosome 3 at 61,003,697 bp
  • A to G, chromosome 3 at 63,701,943 bp
  • G to A, chromosome 3 at 92,945,451 bp
  • A to G, chromosome 3 at 103,961,523 bp
  • T to A, chromosome 4 at 104,986,250 bp
  • C to A, chromosome 4 at 154,019,431 bp
  • T to C, chromosome 5 at 69,541,035 bp
  • A to G, chromosome 5 at 72,203,573 bp
  • A to T, chromosome 5 at 108,124,605 bp
  • A to G, chromosome 5 at 117,380,803 bp
  • A to G, chromosome 5 at 129,516,107 bp
  • A to T, chromosome 5 at 139,426,133 bp
  • G to A, chromosome 6 at 29,709,971 bp
  • A to G, chromosome 6 at 33,910,587 bp
  • A to G, chromosome 6 at 55,678,969 bp
  • A to T, chromosome 6 at 119,338,116 bp
  • A to G, chromosome 6 at 125,170,127 bp
  • A to G, chromosome 7 at 4,337,786 bp
  • A to T, chromosome 7 at 30,360,454 bp
  • G to A, chromosome 7 at 51,897,325 bp
  • A to T, chromosome 7 at 104,859,393 bp
  • A to T, chromosome 8 at 83,003,605 bp
  • A to G, chromosome 8 at 112,015,403 bp
  • T to A, chromosome 8 at 124,611,491 bp
  • T to C, chromosome 8 at 126,937,072 bp
  • T to C, chromosome 9 at 44,707,979 bp
  • G to T, chromosome 9 at 45,968,829 bp
  • C to T, chromosome 10 at 7,743,569 bp
  • T to C, chromosome 10 at 67,243,952 bp
  • T to C, chromosome 10 at 99,263,824 bp
  • T to C, chromosome 10 at 106,967,041 bp
  • A to G, chromosome 11 at 121,245,394 bp
  • A to C, chromosome 12 at 51,748,542 bp
  • T to C, chromosome 13 at 114,990,045 bp
  • T to C, chromosome 14 at 7,927,466 bp
  • A to G, chromosome 14 at 14,052,975 bp
  • A to G, chromosome 14 at 60,291,987 bp
  • T to A, chromosome 14 at 78,908,157 bp
  • A to G, chromosome 15 at 44,527,767 bp
  • A to G, chromosome 15 at 44,636,804 bp
  • T to C, chromosome 15 at 77,763,912 bp
  • A to G, chromosome 17 at 6,782,642 bp
  • A to T, chromosome 17 at 34,568,715 bp
  • A to G, chromosome 17 at 45,663,536 bp
  • T to C, chromosome 17 at 64,714,591 bp
  • T to C, chromosome 18 at 63,117,720 bp
  • T to A, chromosome 19 at 12,862,387 bp
  • T to A, chromosome 19 at 21,400,672 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2078 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040083-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.