Strain Name:
C57BL/6J-MtgxR2167Btlr/Mmmh
Stock Number:
040170-MU
Citation ID:
RRID:MMRRC_040170-MU
Other Names:
R2167 (G1), C57BL/6J-MtgxR2167Btlr
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: urehr3, Nkcc2, mBSC1, D630042G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Fasl
Name: Fas ligand
Synonyms: CD178, Tnfsf6, Fas-L, APT1LG1, Fasl, CD95L
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14103
Homologene: 533
Lhx6
Name: LIM homeobox protein 6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16874
Homologene: 7401
Ptch1
Name: patched 1
Synonyms: wig, Ptc, A230106A15Rik, Ptc1, Patched 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Ccne2
Name: cyclin E2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Ube2e1
Name: ubiquitin-conjugating enzyme E2E 1
Synonyms: ubcM2, UbcM3, Ubce5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22194
Homologene: 84372
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: Sin1, D230039K05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227743
Homologene: 11473
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9630002H22Rik, 9430093I07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Leo1
Name: Leo1, Paf1/RNA polymerase II complex component
Synonyms: LOC235497
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235497
VEGA: 9
Homologene: 133895
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: 5430405C01Rik, GOLTC1, GTC90
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238123
VEGA: 12
Homologene: 42221
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: 6230400I06Rik, Apaf1l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22045
VEGA: 15
Homologene: 20707
Msh6
Name: mutS homolog 6
Synonyms: GTBP, Msh6, Gtmbp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, Supt6h, 5131400N11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20926
Homologene: 40661
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: E-NCAM, NCAM-180, NCAM-140, CD56, NCAM-120, NCAM-1, NCAM
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 9430010A17Rik, 5830445G22Rik, Whsc1, D030027O06Rik, C130020C13Rik, D930023B08Rik, Whsc1l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Casp2
Name: caspase 2
Synonyms: Caspase-2, Nedd2, Ich-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12366
HGNC: HGNC:1503
Homologene: 7254
Rb1
Name: RB transcriptional corepressor 1
Synonyms: Rb-1, pRb, Rb, retinoblastoma 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Calm2
Name: calmodulin 2
Synonyms: 1500001E21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12314
HGNC: HGNC:1445
Homologene: 116117
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Zfp580
Name: zinc finger protein 580
Synonyms: 1500015O20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68992
Homologene: 82467
Foxp2
Name: forkhead box P2
Synonyms: D0Kist7, 2810043D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114142
Homologene: 134404
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Fcer2a
Name: Fc receptor, IgE, low affinity II, alpha polypeptide
Synonyms: Ly-42, FC epsilon RII, CD23, Fce2, low-affinity IgE receptor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14128
HGNC: HGNC:3612
Homologene: 1517
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, Adgrc2, flamingo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Tbx15
Name: T-box 15
Synonyms: Tbx14, de, Tbx8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21384
Homologene: 7967
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Acas1, Facl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, RASSF4, 2010003K16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74030
Homologene: 32430
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Maz
Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Synonyms: SAF-2, PUR1, Pur-1, SAF-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17188
HGNC: HGNC:6914
Homologene: 106451
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76718
Homologene: 10915
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAPP-A, IGFBP-4ase, 8430414N03Rik, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Olfr1564, Gm4461
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: MOR258-1, GA_x6K02T2QD9B-18838170-18837232, Olfr1341
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Zfp235
Name: zinc finger protein 235
Synonyms: 0610030O19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56525
Homologene: 122146
Disp2
Name: dispatched RND transporter family member 2
Synonyms: B230210L08Rik, DispB
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Clnk
Name: cytokine-dependent hematopoietic cell linker
Synonyms: MIST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27278
Homologene: 8450
Or5h23
Name: olfactory receptor family 5 subfamily H member 23
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P, Olfr191
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258035
Homologene: 128162
Acan
Name: aggrecan
Synonyms: b2b183Clo, Agc1, Cspg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Rfpl4
Name: ret finger protein-like 4
Synonyms: D7Ertd486e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192658
Homologene: 90101
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: D130012J15Rik, NTT4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Facl6, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Mknk2
Name: MAP kinase-interacting serine/threonine kinase 2
Synonyms: Mnk2, 2010016G11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17347
HGNC: HGNC:7111
Homologene: 49674
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71718
Homologene: 41107
Art1
Name: ADP-ribosyltransferase 1
Synonyms: Yac-1, ADPRT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11870
HGNC: HGNC:723
Homologene: 128621
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66971
Homologene: 9502
Bhmt2
Name: betaine-homocysteine methyltransferase 2
Synonyms: D13Ucla2, C81077
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 64918
HGNC: HGNC:1048
Homologene: 49496
Dmrtc2
Name: doublesex and mab-3 related transcription factor like family C2
Synonyms: Dmrt7, 4933432E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71241
Homologene: 75260
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, Olfr709, MOR260-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Kctd6
Name: potassium channel tetramerisation domain containing 6
Synonyms: 5430433B02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71393
VEGA: 14
Homologene: 12392
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73246
Homologene: 37125
Rnase6
Name: ribonuclease, RNase A family, 6
Synonyms: 9530043P15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78416
VEGA: 14
Homologene: 4102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 161,787,138 bp
  • T to C, chromosome 2 at 31,415,192 bp
  • T to C, chromosome 2 at 34,597,482 bp
  • C to A, chromosome 2 at 36,103,359 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • A to C, chromosome 2 at 118,791,685 bp
  • A to G, chromosome 2 at 125,173,681 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • A to T, chromosome 2 at 154,370,625 bp
  • A to G, chromosome 3 at 99,326,455 bp
  • A to G, chromosome 3 at 100,591,900 bp
  • A to T, chromosome 3 at 107,491,501 bp
  • T to C, chromosome 3 at 108,413,193 bp
  • A to T, chromosome 4 at 11,197,249 bp
  • A to C, chromosome 4 at 65,156,445 bp
  • T to A, chromosome 4 at 117,028,540 bp
  • T to C, chromosome 4 at 118,710,055 bp
  • T to A, chromosome 5 at 33,882,919 bp
  • C to T, chromosome 5 at 38,774,618 bp
  • C to T, chromosome 5 at 90,603,938 bp
  • C to G, chromosome 6 at 15,437,902 bp
  • C to A, chromosome 6 at 42,276,943 bp
  • C to A, chromosome 7 at 5,053,064 bp
  • T to A, chromosome 7 at 5,110,853 bp
  • T to A, chromosome 7 at 24,140,962 bp
  • C to T, chromosome 7 at 24,873,919 bp
  • T to C, chromosome 7 at 29,698,172 bp
  • A to G, chromosome 7 at 79,099,957 bp
  • GGCG to GGCGACGGCAGCG, chromosome 7 at 97,579,906 bp
  • T to C, chromosome 7 at 102,106,824 bp
  • A to G, chromosome 7 at 106,926,590 bp
  • G to A, chromosome 7 at 127,024,628 bp
  • A to G, chromosome 8 at 3,688,018 bp
  • A to G, chromosome 8 at 46,533,590 bp
  • G to T, chromosome 9 at 49,568,481 bp
  • A to G, chromosome 9 at 75,445,709 bp
  • T to C, chromosome 9 at 110,638,308 bp
  • A to G, chromosome 10 at 80,668,701 bp
  • G to A, chromosome 10 at 91,060,039 bp
  • G to A, chromosome 10 at 127,742,975 bp
  • C to T, chromosome 11 at 9,288,532 bp
  • C to A, chromosome 11 at 54,327,157 bp
  • G to A, chromosome 11 at 78,208,167 bp
  • T to A, chromosome 11 at 107,672,964 bp
  • T to C, chromosome 12 at 31,837,289 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to T, chromosome 13 at 93,662,504 bp
  • T to C, chromosome 14 at 8,222,683 bp
  • T to C, chromosome 14 at 18,284,429 bp
  • A to C, chromosome 14 at 51,130,517 bp
  • T to C, chromosome 14 at 73,211,651 bp
  • C to T, chromosome 15 at 44,229,242 bp
  • G to A, chromosome 15 at 50,831,730 bp
  • C to A, chromosome 15 at 78,672,446 bp
  • T to C, chromosome 16 at 20,213,401 bp
  • T to A, chromosome 16 at 59,085,586 bp
  • A to G, chromosome 17 at 25,110,818 bp
  • T to C, chromosome 17 at 29,162,332 bp
  • T to A, chromosome 17 at 33,215,568 bp
  • T to C, chromosome 17 at 87,435,145 bp
  • A to G, chromosome 17 at 87,989,483 bp
  • A to G, chromosome 19 at 6,317,677 bp
  • G to T, chromosome 19 at 6,854,084 bp
  • A to T, chromosome 19 at 9,011,494 bp
  • G to A, chromosome 19 at 44,543,353 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2167 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040170-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.