Strain Name:
C57BL/6J-MtgxR2176Btlr/Mmmh
Stock Number:
040178-MU
Citation ID:
RRID:MMRRC_040178-MU
Other Names:
R2176 (G1), C57BL/6J-MtgxR2176Btlr
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Mllt1
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Synonyms: LTG19, ENL, BAM11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64144
VEGA: 17
HGNC: HGNC:7134
Homologene: 4339
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Armc9
Name: armadillo repeat containing 9
Synonyms: 4831423D23Rik, 5730415N24Rik, 3830422A13Rik, 4930438O05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78795
Homologene: 11847
Kif13b
Name: kinesin family member 13B
Synonyms: N-3 kinesin, C130021D12Rik, 5330429L19Rik, GAKIN
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Casp3
Name: caspase 3
Synonyms: mldy, CC3, A830040C14Rik, Yama, Apopain, CPP32, Caspase-3, AC-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12367
HGNC: HGNC:1504
Homologene: 37912
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Mrell, Rad50l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Syngr2
Name: synaptogyrin 2
Synonyms: cellugyrin, Clast2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20973
Homologene: 20987
Noct
Name: nocturnin
Synonyms: Ccrn4l, Ccr4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12457
Homologene: 7661
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: Ntrkr1, 2810404D04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26563
Homologene: 3675
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: Calnb, 1110063J16Rik, PP2BA beta, Cnab, CnAbeta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Utf1
Name: undifferentiated embryonic cell transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22286
Homologene: 48226
Wrnip1
Name: Werner helicase interacting protein 1
Synonyms: 4833444L21Rik, WHIP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78903
Homologene: 10592
Ccdc174
Name: coiled-coil domain containing 174
Synonyms: C130022K22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232236
Homologene: 9523
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Mfsd14a
Name: major facilitator superfamily domain containing 14A
Synonyms: Hiat1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15247
Homologene: 22456
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: cGK-II, Prkgr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Fyb1
Name: FYN binding protein 1
Synonyms: FYB-120/130, ADAP, B630013F22Rik, Fyb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Kcna10
Name: potassium voltage-gated channel, shaker-related subfamily, member 10
Synonyms: Kv1.8, Kcna8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242151
HGNC: HGNC:6219
Homologene: 4054
Ccr6
Name: C-C motif chemokine receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232156
Homologene: 31125
Il5ra
Name: interleukin 5 receptor, alpha
Synonyms: CD125, Il5r, CDw125, IL-5 receptor alpha chain
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16192
HGNC: HGNC:6017
Homologene: 473
Kif6
Name: kinesin family member 6
Synonyms: D130084M03Rik, D130004B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319991
Homologene: 35308
Dennd5a
Name: DENN domain containing 5A
Synonyms: 1500012B19Rik, ORF37, Rab6ip1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19347
Homologene: 14584
Vmn1r208
Name: vomeronasal 1 receptor 208
Synonyms: Vmn1r208-ps, V1rh9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171252
Homologene: 110880
Rgl3
Name: ral guanine nucleotide dissociation stimulator-like 3
Synonyms: 1300003D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71746
VEGA: 9
Homologene: 11363
Or10a3m
Name: olfactory receptor family 10 subfamily A member 3M
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3, Olfr512
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258719
HGNC: HGNC:8162
Homologene: 138316
Myo15b
Name: myosin XVB
Synonyms: LOC380737, E330039G21Rik, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Nell2
Name: NEL-like 2
Synonyms: mel91, A330108N19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: Opo, ojoplano
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Or11h4
Name: olfactory receptor family 11 subfamily H member 4
Synonyms: GA_x6K02T2PMLR-6484046-6483105, Olfr749, MOR106-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56858
Homologene: 10652
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: Rgsl2, 4930415K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), 1110004F14Rik, alphav-integrin, 2610028E01Rik, CD51, D430040G12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Tph1
Name: tryptophan hydroxylase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21990
Homologene: 121565
Sdr42e1
Name: short chain dehydrogenase/reductase family 42E, member 1
Synonyms: 4632417N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74032
Homologene: 23654
Inhca
Name: inhibitor of carbonic anhydrase
Synonyms: mICA, 1300017J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71775
Homologene: 826
Tm9sf1
Name: transmembrane 9 superfamily member 1
Synonyms: MP70, 1200014D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74140
Homologene: 4671
Psg28
Name: pregnancy-specific beta-1-glycoprotein 28
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114871
Homologene: 110989
Poll
Name: polymerase (DNA directed), lambda
Synonyms: 1110003P06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56626
VEGA: 19
HGNC: HGNC:9184
Homologene: 40863
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67538
Homologene: 15436
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Or4a75
Name: olfactory receptor family 4 subfamily A member 75
Synonyms: Olfr1248, MOR231-10, GA_x6K02T2Q125-51059648-51058725
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258787
Homologene: 133613
Mterf3
Name: mitochondrial transcription termination factor 3
Synonyms: 2410017I18Rik, Mterfd1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66410
Homologene: 9310
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: PLP-F, Prlpf
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19114
Homologene: 49263
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: fertilin alpha, PH-30 alpha, Ftna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
AC122428.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Ypel2
Name: yippee like 2
Synonyms: E130113K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77864
Homologene: 70791
Gm20403
Name: predicted gene 20403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,553,517 bp
  • T to C, chromosome 1 at 86,199,892 bp
  • A to G, chromosome 1 at 150,419,940 bp
  • T to A, chromosome 1 at 153,825,268 bp
  • A to T, chromosome 1 at 181,135,074 bp
  • C to T, chromosome 2 at 83,803,255 bp
  • A to T, chromosome 2 at 89,617,580 bp
  • T to C, chromosome 2 at 112,666,335 bp
  • G to T, chromosome 2 at 164,820,694 bp
  • G to A, chromosome 2 at 181,991,337 bp
  • G to A, chromosome 3 at 51,249,696 bp
  • A to T, chromosome 3 at 95,065,496 bp
  • T to C, chromosome 3 at 107,194,716 bp
  • T to C, chromosome 3 at 116,632,393 bp
  • T to A, chromosome 4 at 88,279,244 bp
  • C to A, chromosome 4 at 100,441,874 bp
  • T to C, chromosome 4 at 116,973,041 bp
  • T to C, chromosome 5 at 98,966,509 bp
  • T to A, chromosome 5 at 121,519,586 bp
  • T to G, chromosome 5 at 137,421,848 bp
  • G to T, chromosome 6 at 47,820,971 bp
  • G to A, chromosome 6 at 83,262,560 bp
  • G to A, chromosome 6 at 91,888,089 bp
  • A to G, chromosome 6 at 106,738,272 bp
  • A to G, chromosome 6 at 113,151,153 bp
  • T to A, chromosome 7 at 18,427,879 bp
  • T to G, chromosome 7 at 27,364,162 bp
  • T to C, chromosome 7 at 43,351,716 bp
  • T to A, chromosome 7 at 46,662,039 bp
  • A to G, chromosome 7 at 83,609,308 bp
  • G to A, chromosome 7 at 108,714,132 bp
  • C to A, chromosome 7 at 109,905,120 bp
  • A to G, chromosome 7 at 112,092,727 bp
  • A to G, chromosome 7 at 139,944,007 bp
  • A to G, chromosome 8 at 46,629,756 bp
  • A to G, chromosome 8 at 117,612,994 bp
  • A to T, chromosome 8 at 117,662,877 bp
  • A to G, chromosome 9 at 21,975,958 bp
  • A to G, chromosome 9 at 44,464,259 bp
  • A to G, chromosome 9 at 103,259,367 bp
  • T to C, chromosome 10 at 33,595,815 bp
  • T to A, chromosome 11 at 34,695,217 bp
  • A to G, chromosome 11 at 53,698,209 bp
  • A to G, chromosome 11 at 55,267,575 bp
  • T to A, chromosome 11 at 86,971,873 bp
  • T to C, chromosome 11 at 115,866,572 bp
  • T to C, chromosome 11 at 117,812,580 bp
  • A to T, chromosome 12 at 51,745,494 bp
  • T to C, chromosome 12 at 54,986,370 bp
  • A to T, chromosome 13 at 22,772,602 bp
  • T to G, chromosome 13 at 27,659,106 bp
  • T to C, chromosome 13 at 32,820,240 bp
  • T to C, chromosome 13 at 40,097,119 bp
  • A to T, chromosome 13 at 60,784,530 bp
  • A to T, chromosome 13 at 66,916,693 bp
  • A to T, chromosome 14 at 20,520,652 bp
  • T to C, chromosome 14 at 50,736,224 bp
  • T to C, chromosome 14 at 55,641,409 bp
  • G to A, chromosome 14 at 64,669,671 bp
  • A to G, chromosome 15 at 6,579,954 bp
  • A to T, chromosome 15 at 76,911,660 bp
  • T to C, chromosome 15 at 95,435,157 bp
  • T to A, chromosome 17 at 8,256,241 bp
  • C to A, chromosome 17 at 32,056,560 bp
  • G to A, chromosome 17 at 49,755,230 bp
  • A to G, chromosome 17 at 56,897,398 bp
  • T to C, chromosome 17 at 58,013,946 bp
  • A to G, chromosome 19 at 38,896,079 bp
  • A to T, chromosome 19 at 45,553,688 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2176 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040178-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.