Strain Name:
C57BL/6J-MtgxR2198Btlr/Mmmh
Stock Number:
040200-MU
Citation ID:
RRID:MMRRC_040200-MU
Other Names:
R2198 (G1), C57BL/6J-MtgxR2198Btlr
Major Collection:

Strain Information

Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Ppp1cb
Name: protein phosphatase 1 catalytic subunit beta
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19046
HGNC: HGNC:9282
Homologene: 37659
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Sfrs16, Srsf16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Bag3
Name: BCL2-associated athanogene 3
Synonyms: Bis, Bcl-2-interacting death suppressor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29810
HGNC: HGNC:939
Homologene: 3162
Rad23b
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: mHR23B, 0610007D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19359
HGNC: HGNC:9813
Homologene: 37704
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, D130072O21Rik, tankyrase 1, TANK1, mTNKS1, Parp5a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 1700016A15Rik, 1010001P15Rik, 2700069A02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75553
VEGA: 12
Homologene: 32605
Usp22
Name: ubiquitin specific peptidase 22
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216825
Homologene: 52664
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Nifk
Name: nucleolar protein interacting with the FHA domain of MKI67
Synonyms: C130020J04Rik, Mki67ip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67949
Homologene: 49862
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: PILSAP, ERAAP, Arts1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Celf6
Name: CUGBP, Elav-like family member 6
Synonyms: 6330569O16Rik, Brunol6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76183
Homologene: 129318
Erh
Name: ERH mRNA splicing and mitosis factor
Synonyms: Mer, Prei1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13877
HGNC: HGNC:3447
Homologene: 3274
Rmnd5b
Name: required for meiotic nuclear division 5 homolog B
Synonyms: 0610039K22Rik, Gid2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66089
Homologene: 100777
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Mek4, Hek4, Hek, Cek4, End3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Glce
Name: glucuronyl C5-epimerase
Synonyms: heparan sulfate-glucuronic acid C5-epimerase, Hsepi, C130034A12Rik, 1110017N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93683
Homologene: 14111
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Gm4884
Name: predicted gene 4884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233164
Vmn1r78
Name: vomeronasal 1 receptor 78
Synonyms: V1rg7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171242
Homologene: 74316
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Gstt4
Name: glutathione S-transferase, theta 4
Synonyms: 4930583C14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75886
Homologene: 57104
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218865
Homologene: 41261
Ctse
Name: cathepsin E
Synonyms: CE, CatE, A430072O03Rik, C920004C08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: Ncx1, D930008O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Sobp
Name: sine oculis binding protein
Synonyms: 2900009C16Rik, 5330439J01Rik, Jxc1, jc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109205
Homologene: 41216
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Pip4k2a
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Synonyms: Pip5k2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18718
HGNC: HGNC:8997
Homologene: 37995
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Fyn
Name: Fyn proto-oncogene
Synonyms: Src Kinase p59
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14360
HGNC: HGNC:4037
Homologene: 48068
Olfr144
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Akr1c21
Name: aldo-keto reductase family 1, member C21
Synonyms: 9430025F20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77337
Homologene: 134114
Shc4
Name: SHC (Src homology 2 domain containing) family, member 4
Synonyms: 9930029B02Rik, LOC271849, 6230417E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271849
Homologene: 19567
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Ctnna3
Name: catenin alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin, catenin (cadherin associated protein), alpha 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231464
Homologene: 100830
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21886
Homologene: 20693
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Mrpl54
Name: mitochondrial ribosomal protein L54
Synonyms: 0610008M19Rik, D10Sut1e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66047
Homologene: 11910
Slc26a9
Name: solute carrier family 26, member 9
Synonyms: anion transporter/exchanger-9, E030002L01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320718
Homologene: 14179
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: acid ceramidase, 2310081N20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Adra1a
Name: adrenergic receptor, alpha 1a
Synonyms: Adra1c
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11549
HGNC: HGNC:277
Homologene: 68078
Ac165356.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Or2y16
Name: olfactory receptor family 2 subfamily Y member 16
Synonyms: GA_x6K02T2QP88-5991012-5990077, MOR256-28, Olfr1388
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258459
Homologene: 74258
Or6c88
Name: olfactory receptor family 6 subfamily C member 88
Synonyms: GA_x6K02T2PULF-11248702-11249664, MOR114-11, Olfr794
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258375
Homologene: 45066
Cep295nl
Name: CEP295 N-terminal like
Synonyms: Ddc8, BC100451
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58251
Homologene: 75164
Or2r11
Name: olfactory receptor family 2 subfamily R member 11
Synonyms: GA_x6K02T2P3E9-5100053-5100994, MOR257-4, Olfr458
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258436
Homologene: 133704
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,910,746 bp
  • A to G, chromosome 1 at 36,794,913 bp
  • G to A, chromosome 1 at 60,141,484 bp
  • A to T, chromosome 1 at 104,947,322 bp
  • A to G, chromosome 1 at 118,329,400 bp
  • T to G, chromosome 1 at 131,672,447 bp
  • A to G, chromosome 1 at 131,763,263 bp
  • A to T, chromosome 1 at 164,207,034 bp
  • A to T, chromosome 2 at 18,847,655 bp
  • A to T, chromosome 2 at 125,639,346 bp
  • C to T, chromosome 3 at 25,433,761 bp
  • T to C, chromosome 3 at 126,934,577 bp
  • G to A, chromosome 4 at 55,385,497 bp
  • G to T, chromosome 5 at 32,483,360 bp
  • C to T, chromosome 5 at 96,079,941 bp
  • A to T, chromosome 5 at 104,175,701 bp
  • A to G, chromosome 6 at 42,461,016 bp
  • T to C, chromosome 6 at 119,347,259 bp
  • G to T, chromosome 7 at 12,152,560 bp
  • A to T, chromosome 7 at 19,584,353 bp
  • G to T, chromosome 7 at 29,527,272 bp
  • T to C, chromosome 7 at 30,057,511 bp
  • A to G, chromosome 7 at 41,040,805 bp
  • T to A, chromosome 7 at 106,083,551 bp
  • AAAGG to AAAGGAAGG, chromosome 7 at 128,545,769 bp
  • A to T, chromosome 8 at 34,848,649 bp
  • C to T, chromosome 8 at 34,873,067 bp
  • C to A, chromosome 8 at 41,343,873 bp
  • T to A, chromosome 8 at 61,958,063 bp
  • A to G, chromosome 9 at 21,732,402 bp
  • G to A, chromosome 9 at 39,237,752 bp
  • G to T, chromosome 9 at 59,603,339 bp
  • A to T, chromosome 9 at 62,068,371 bp
  • T to G, chromosome 10 at 10,782,776 bp
  • T to A, chromosome 10 at 26,330,166 bp
  • A to G, chromosome 10 at 39,529,545 bp
  • A to C, chromosome 10 at 43,022,524 bp
  • C to A, chromosome 10 at 65,002,745 bp
  • T to C, chromosome 10 at 75,822,401 bp
  • C to T, chromosome 10 at 80,887,459 bp
  • G to A, chromosome 10 at 81,265,741 bp
  • T to C, chromosome 10 at 81,590,313 bp
  • T to A, chromosome 10 at 129,571,046 bp
  • T to G, chromosome 11 at 29,850,935 bp
  • C to T, chromosome 11 at 49,443,959 bp
  • C to T, chromosome 11 at 51,624,586 bp
  • A to G, chromosome 11 at 61,159,337 bp
  • A to G, chromosome 11 at 65,859,499 bp
  • C to T, chromosome 11 at 75,446,081 bp
  • A to T, chromosome 11 at 118,332,593 bp
  • T to C, chromosome 12 at 80,642,785 bp
  • G to A, chromosome 12 at 98,752,809 bp
  • G to A, chromosome 12 at 98,752,810 bp
  • C to T, chromosome 13 at 4,577,465 bp
  • C to T, chromosome 13 at 74,646,687 bp
  • A to G, chromosome 13 at 92,763,271 bp
  • A to T, chromosome 13 at 100,152,592 bp
  • T to A, chromosome 14 at 30,031,532 bp
  • T to C, chromosome 14 at 66,637,936 bp
  • A to G, chromosome 15 at 76,636,672 bp
  • T to C, chromosome 16 at 63,844,144 bp
  • T to A, chromosome 17 at 81,408,256 bp
  • T to C, chromosome 18 at 20,461,442 bp
  • T to C, chromosome 18 at 65,350,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040200-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.