Strain Name:
C57BL/6J-MtgxR2292Btlr/Mmmh
Stock Number:
040291-MU
Citation ID:
RRID:MMRRC_040291-MU
Other Names:
R2292 (G1), C57BL/6J-MtgxR2292Btlr
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-alpha, Frabin-beta, Frabin, Frabin-gamma, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: Grlf1, p190RhoGAP, p190A, P190 RhoGAP, 6430596G11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Fkbp4
Name: FK506 binding protein 4
Synonyms: FKBP52, FKBP-52
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14228
HGNC: HGNC:3720
Homologene: 36085
Ddx55
Name: DEAD box helicase 55
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 55, 2810021H22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 3222402C23Rik, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Mphosph10
Name: M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms: 5730405D16Rik, 2810453H10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67973
HGNC: HGNC:7213
Homologene: 134741
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Ascc2
Name: activating signal cointegrator 1 complex subunit 2
Synonyms: ASC1p100, 2610034L15Rik, 1700011I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75452
Homologene: 41774
Letm1
Name: leucine zipper-EF-hand containing transmembrane protein 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56384
HGNC: HGNC:6556
Homologene: 56320
Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Synonyms: Zpk, MUK, DLK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26404
HGNC: HGNC:6851
Homologene: 4592
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, Zfp650, 4833421P10Rik, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Mgl2
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms: CD301b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216864
Homologene: 7836
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Trak2
Name: trafficking protein, kinesin binding 2
Synonyms: GRIF-1, CALS-C, 2900022D04Rik, OIP98, Als2cr3, GRIF1, 4733401O11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70827
Homologene: 22861
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: 6530403F17Rik, A530023E23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244867
Homologene: 18938
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 9830132G07Rik, 8430415N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226470
Homologene: 27795
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Iqcg
Name: IQ motif containing G
Synonyms: stubby12d, G1-374-12, repro1, 2400003L07Rik, esgd12d
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69707
Homologene: 32776
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Dym
Name: dymeclin
Synonyms: 1810041M12Rik, 4933427L07Rik, C030019K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69190
VEGA: 18
Homologene: 69237
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Pramel25
Name: PRAME like 25
Synonyms: MGC:91194, Gm13023
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194227
Homologene: 103830
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: Olfr517, GA_x6K02T2PBJ9-11199311-11198367, MOR268-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Or2w6
Name: olfactory receptor family 2 subfamily W member 6
Synonyms: MOR256-12, GA_x6K02T2QHY8-11577590-11578528, Olfr1361
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258534
Homologene: 88362
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319807
Homologene: 14974
Psmc4
Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4
Synonyms: CIP21, CAR interacting protein 21, MIP224
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23996
HGNC: HGNC:9551
Homologene: 4744
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Ntn5
Name: netrin 5
Synonyms: LOC243967
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243967
Homologene: 17106
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99681
Homologene: 136273
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Pccb
Name: propionyl Coenzyme A carboxylase, beta polypeptide
Synonyms: 1300012P06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66904
HGNC: HGNC:8654
Homologene: 447
Gpr182
Name: G protein-coupled receptor 182
Synonyms: Gpcr22, NOW, Gpcr17, G10-D, AM-R, Admr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11536
Homologene: 5255
Dvl1
Name: dishevelled segment polarity protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13542
Homologene: 20926
Tmem192
Name: transmembrane protein 192
Synonyms: 3110005G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73067
Homologene: 16751
Gdf2
Name: growth differentiation factor 2
Synonyms: Bmp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12165
VEGA: 14
HGNC: HGNC:4217
Homologene: 32299
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 4432406M01Rik, 1110034E15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Dctn6
Name: dynactin 6
Synonyms: p27, WS-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22428
Homologene: 4792
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: OTTMUSG00000006090, Nalp1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Ttc9b
Name: tetratricopeptide repeat domain 9B
Synonyms: 2900074C18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73032
Homologene: 19938
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,935,757 bp
  • T to C, chromosome 1 at 59,187,385 bp
  • T to C, chromosome 1 at 139,440,359 bp
  • C to T, chromosome 2 at 24,606,620 bp
  • T to C, chromosome 2 at 68,732,139 bp
  • G to T, chromosome 2 at 69,897,260 bp
  • A to T, chromosome 3 at 93,220,677 bp
  • A to G, chromosome 3 at 93,442,382 bp
  • A to C, chromosome 4 at 21,683,914 bp
  • T to C, chromosome 4 at 59,690,579 bp
  • T to C, chromosome 4 at 143,793,876 bp
  • G to A, chromosome 4 at 155,847,816 bp
  • A to AG, chromosome 5 at 33,769,515 bp
  • A to T, chromosome 5 at 63,805,574 bp
  • G to T, chromosome 5 at 124,568,077 bp
  • G to A, chromosome 6 at 73,021,109 bp
  • A to G, chromosome 6 at 121,673,559 bp
  • A to C, chromosome 6 at 128,436,662 bp
  • A to T, chromosome 7 at 16,563,551 bp
  • A to G, chromosome 7 at 27,655,980 bp
  • A to G, chromosome 7 at 28,042,991 bp
  • G to A, chromosome 7 at 45,691,403 bp
  • G to A, chromosome 7 at 64,385,771 bp
  • A to T, chromosome 7 at 67,669,787 bp
  • A to C, chromosome 7 at 86,148,936 bp
  • A to T, chromosome 7 at 108,869,016 bp
  • T to C, chromosome 8 at 34,092,525 bp
  • C to T, chromosome 8 at 47,505,736 bp
  • T to C, chromosome 8 at 64,959,346 bp
  • T to A, chromosome 9 at 51,849,443 bp
  • T to C, chromosome 9 at 100,994,632 bp
  • A to G, chromosome 10 at 127,750,182 bp
  • T to C, chromosome 11 at 4,679,352 bp
  • A to G, chromosome 11 at 70,135,909 bp
  • A to G, chromosome 11 at 71,246,362 bp
  • G to T, chromosome 12 at 71,061,541 bp
  • T to G, chromosome 13 at 13,740,495 bp
  • A to G, chromosome 13 at 21,658,831 bp
  • A to G, chromosome 14 at 29,062,551 bp
  • A to T, chromosome 14 at 31,736,751 bp
  • T to G, chromosome 14 at 32,173,456 bp
  • A to T, chromosome 14 at 33,945,188 bp
  • T to C, chromosome 15 at 102,500,139 bp
  • A to T, chromosome 16 at 16,436,000 bp
  • A to G, chromosome 16 at 33,049,883 bp
  • T to A, chromosome 18 at 11,720,671 bp
  • T to A, chromosome 18 at 37,297,244 bp
  • A to G, chromosome 18 at 75,199,212 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2292 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040291-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.