Strain Name:
C57BL/6J-MtgxR3430Btlr/Mmmh
Stock Number:
040648-MU
Citation ID:
RRID:MMRRC_040648-MU
Other Names:
R3430 (G1), C57BL/6J-MtgxR3430Btlr
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Todo, Gena 52, GENA 60, Dz, Cycn, Cyn, Obt, Mt, Whi, GENA 47, A730019I05Rik, Lda, Flo, Edy, WBE1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Otx2
Name: orthodenticle homeobox 2
Synonyms: E130306E05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18424
HGNC: HGNC:8522
Homologene: 11026
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NR3A, NMDAR-L, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67800
Homologene: 23580
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: Mcaf1, ATFa-associated Modulator, AM, 2610204M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54343
Homologene: 10051
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph-1, Mdgi, Fabph1, H-FABP, Fabph-4, Fabp3, Fabph4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: mSmile, 9130014E20Rik, B130008E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237500
Homologene: 27616
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, YR-23, D1Bwg0491e, Rw1, Neg, 2610524E03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2h, Pwp2, 6530411D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: GIV, C330012F17Rik, A430106J12Rik, D130005J21Rik, HkRP1, C130096N06Rik, Girdin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108686
Homologene: 41180
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244152
Homologene: 41045
Bhmt
Name: betaine-homocysteine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12116
HGNC: HGNC:1047
Homologene: 1295
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: B430006D22Rik, D230004J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Scn6a, Nax, NaG, Nav2, Nav2.3, 1110034K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Parp3
Name: poly (ADP-ribose) polymerase family, member 3
Synonyms: Adprt3, PARP-3, A930002C11Rik, Adprtl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235587
HGNC: HGNC:273
Homologene: 4005
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Rsad2
Name: radical S-adenosyl methionine domain containing 2
Synonyms: Vig1, 2510004L01Rik, cig5, viperin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 58185
Homologene: 10969
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: MOR135-6, Olfr389, GA_x6K02T2P1NL-3932085-3931147
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226250
Homologene: 13057
Prss34
Name: serine protease 34
Synonyms: mMcp-11, mast cell protease 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328780
VEGA: 17
Homologene: 55542
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, Perforin-2, MPS1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Bpifa6
Name: BPI fold containing family A, member 6
Synonyms: Gm5840
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545477
Homologene: 129594
Or4c29
Name: olfactory receptor family 4 subfamily C member 29
Synonyms: GA_x6K02T2Q125-50386882-50385950, MOR230-7, Olfr1209
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258453
Homologene: 128155
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: 2610209L14Rik, Snf2l2, brm
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Arhgef19
Name: Rho guanine nucleotide exchange factor 19
Synonyms: 6430573B13Rik, WGEF
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213649
Homologene: 17710
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Serpinb3b
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
Synonyms: Scca2-rs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383548
Homologene: 131278
Cimip1
Name: ciliary microtubule inner protein 1
Synonyms: 1700021F07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72221
Homologene: 82371
S1pr5
Name: sphingosine-1-phosphate receptor 5
Synonyms: lpB4, S1P5, Edg8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94226
Homologene: 11031
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: T1r2, TR2, Gpr71
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Mapk8ip2
Name: mitogen-activated protein kinase 8 interacting protein 2
Synonyms: JNK-interacting protein, 3230402N03Rik, IB2, Jip2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 60597
HGNC: HGNC:6883
Homologene: 8201
FP885536.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Or4e5
Name: olfactory receptor family 4 subfamily E member 5
Synonyms: MOR244-1, GA_x6K02T2RJGY-491851-492792, MOR28, Olfr1507
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57269
HGNC: HGNC:8296
Homologene: 10736
Or8b3b
Name: olfactory receptor family 8 subfamily B member 3B
Synonyms: Olfr918, MOR164-3, GA_x6K02T2PVTD-32375756-32374818
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258372
VEGA: 9
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Or2b7
Name: olfactory receptor family 2 subfamily B member 7
Synonyms: MOR256-36, MOR256-36, Olfr1365, GA_x6K02T2QHY8-11688984-11689964, MOR256-63, Olfr1535
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 404335
Homologene: 131356
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66938
Homologene: 12057
Ptpn20
Name: protein tyrosine phosphatase, non-receptor type 20
Synonyms: typ
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19256
VEGA: 14
Homologene: 74905
Sh3yl1
Name: Sh3 domain YSC-like 1
Synonyms: YSC84, Ray
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24057
Homologene: 31662
Lce1d
Name: late cornified envelope 1D
Synonyms: 2310037L11Rik, Sprrl7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69611
Gm10323
Name: predicted gene 10323
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105245545
VEGA: 13
Lkaaear1
Name: LKAAEAR motif containing 1 (IKAAEAR murine motif)
Synonyms: 4930526D03Rik, LOC277496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277496
Homologene: 52380
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 11,149,854 bp
  • A to G, chromosome 1 at 36,808,821 bp
  • A to T, chromosome 1 at 107,154,695 bp
  • AT to ATT, chromosome 2 at 66,700,895 bp
  • C to T, chromosome 2 at 88,909,466 bp
  • A to G, chromosome 2 at 153,989,251 bp
  • T to C, chromosome 2 at 173,528,273 bp
  • T to C, chromosome 2 at 180,196,317 bp
  • T to A, chromosome 2 at 181,013,285 bp
  • T to C, chromosome 2 at 181,697,531 bp
  • C to T, chromosome 3 at 59,218,027 bp
  • A to T, chromosome 3 at 92,685,730 bp
  • T to C, chromosome 4 at 8,844,517 bp
  • C to A, chromosome 4 at 49,792,534 bp
  • T to C, chromosome 4 at 82,498,295 bp
  • A to G, chromosome 4 at 121,150,532 bp
  • A to G, chromosome 4 at 126,162,832 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to G, chromosome 4 at 139,669,575 bp
  • T to C, chromosome 4 at 141,256,800 bp
  • G to T, chromosome 4 at 156,334,397 bp
  • A to T, chromosome 6 at 48,906,076 bp
  • A to C, chromosome 6 at 67,452,474 bp
  • G to A, chromosome 6 at 73,121,814 bp
  • A to G, chromosome 6 at 83,403,419 bp
  • A to G, chromosome 6 at 136,575,324 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • T to C, chromosome 7 at 45,619,374 bp
  • T to C, chromosome 7 at 98,352,539 bp
  • A to G, chromosome 7 at 99,157,093 bp
  • A to G, chromosome 7 at 105,756,504 bp
  • A to G, chromosome 9 at 21,245,082 bp
  • A to T, chromosome 9 at 38,673,139 bp
  • T to C, chromosome 9 at 48,907,388 bp
  • T to A, chromosome 9 at 54,477,461 bp
  • T to A, chromosome 9 at 79,680,311 bp
  • A to T, chromosome 9 at 79,853,670 bp
  • A to G, chromosome 9 at 104,081,832 bp
  • A to T, chromosome 9 at 106,474,723 bp
  • A to G, chromosome 10 at 78,181,658 bp
  • A to G, chromosome 10 at 100,447,575 bp
  • A to G, chromosome 10 at 115,410,523 bp
  • T to A, chromosome 10 at 130,418,889 bp
  • T to A, chromosome 11 at 29,448,033 bp
  • A to G, chromosome 11 at 30,219,686 bp
  • A to T, chromosome 11 at 73,776,539 bp
  • T to C, chromosome 12 at 26,456,419 bp
  • T to C, chromosome 12 at 30,959,842 bp
  • A to T, chromosome 13 at 21,555,805 bp
  • A to C, chromosome 13 at 66,854,824 bp
  • T to C, chromosome 13 at 93,627,347 bp
  • T to A, chromosome 14 at 33,614,528 bp
  • T to A, chromosome 14 at 48,658,797 bp
  • A to T, chromosome 14 at 52,175,359 bp
  • A to G, chromosome 14 at 52,490,425 bp
  • A to G, chromosome 15 at 89,457,282 bp
  • A to G, chromosome 16 at 14,140,177 bp
  • A to T, chromosome 17 at 25,299,104 bp
  • T to C, chromosome 17 at 50,800,128 bp
  • A to G, chromosome 19 at 9,006,958 bp
  • A to T, chromosome 19 at 12,463,128 bp
  • A to G, chromosome 19 at 26,691,349 bp
  • C to A, chromosome 19 at 56,915,806 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3430 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040648-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.