Strain Name:
C57BL/6J-MtgxR3436Btlr/Mmmh
Stock Number:
040654-MU
Citation ID:
RRID:MMRRC_040654-MU
Other Names:
R3436 (G1), C57BL/6J-MtgxR3436Btlr
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Sort1
Name: sortilin 1
Synonyms: Ntr3, neurotensin receptor 3, Ntsr3, sortilin, 2900053A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20661
Homologene: 136097
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Med25
Name: mediator complex subunit 25
Synonyms: ESTM2, 2610034E13Rik, 2610529E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75613
Homologene: 12614
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Slfn2
Name: schlafen 2
Synonyms: Shlf2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20556
Homologene: 133205
Angptl3
Name: angiopoietin-like 3
Synonyms: hypl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30924
HGNC: HGNC:491
Homologene: 8499
Atp6v1g1
Name: ATPase, H+ transporting, lysosomal V1 subunit G1
Synonyms: lysosomal 13kDa, Atp6g1, Vma10, ATP6J, VAG1, 1810024D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66290
HGNC: HGNC:864
Homologene: 31272
Zfp507
Name: zinc finger protein 507
Synonyms: 1810022O10Rik, A230056M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668501
Homologene: 8942
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: D930040F23Rik, 4631424J17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70802
Homologene: 19687
Dse
Name: dermatan sulfate epimerase
Synonyms: B130024B19Rik, DS-epi1, Sart2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212898
VEGA: 10
Homologene: 8354
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Trim17
Name: tripartite motif-containing 17
Synonyms: terf, Rnf16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56631
Homologene: 9387
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Lpp2, Ppap2c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 270893
Homologene: 41524
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Mll2, Wbp7, 2610014H22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
Or4c102
Name: olfactory receptor family 4 subfamily C member 102
Synonyms: Olfr1189, GA_x6K02T2Q125-50079044-50079964, MOR237-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258768
Homologene: 81569
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Cdc20b
Name: cell division cycle 20B
Synonyms: EG622422, EG238896
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238896
Homologene: 65056
Or2n1d
Name: olfactory receptor family 2 subfamily N member 1D
Synonyms: Olfr136, GA_x6K02T2PSCP-2779375-2780313, MOR256-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258803
Homologene: 119758
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Tmprss11b
Name: transmembrane protease, serine 11B
Synonyms: Tmprss11bnl, 9930019B18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319875
Homologene: 64599
Il24
Name: interleukin 24
Synonyms: FISP, Mda-7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93672
Homologene: 4991
Or2n1e
Name: olfactory receptor family 2 subfamily N member 1E
Synonyms: Olfr89, GA_x6K02T2PSCP-2718585-2719523, Olfr138, MOR256-40P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 170648
Homologene: 119758
Trim52
Name: tripartite motif-containing 52
Synonyms: 4921513B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 212085
Homologene: 79723
Trdn
Name: triadin
Synonyms: triadin-1, EG432451, triadin 3, triadin 1, 2310045H21Rik, triadin-2, triadin-3, triadin 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Amacr
Name: alpha-methylacyl-CoA racemase
Synonyms: 2-arylpropionyl-CoA epimerase, Macr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17117
VEGA: 15
HGNC: HGNC:451
Homologene: 7410
F8
Name: coagulation factor VIII
Synonyms: Cf8, FVIII, Factor VIII, Cf-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 14069
HGNC: HGNC:3546
Homologene: 49153
Optc
Name: opticin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: Intin4, UTI, ulinastatin, ASPI, HI-30, Itil, Urinary Trypsin Inhibitor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Prr16
Name: proline rich 16
Synonyms: 5430406M13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71373
VEGA: 18
Homologene: 41152
Ehd1
Name: EH-domain containing 1
Synonyms: RME-1, Past1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Vsig4
Name: V-set and immunoglobulin domain containing 4
Synonyms: Z39IG, CRIg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278180
Homologene: 48515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 43,940,144 bp
  • A to G, chromosome 1 at 130,887,238 bp
  • T to C, chromosome 1 at 133,897,879 bp
  • T to A, chromosome 2 at 88,592,104 bp
  • T to A, chromosome 3 at 108,337,807 bp
  • T to C, chromosome 4 at 43,097,028 bp
  • C to T, chromosome 4 at 46,523,739 bp
  • T to C, chromosome 4 at 63,149,484 bp
  • A to G, chromosome 4 at 63,550,018 bp
  • A to T, chromosome 4 at 99,033,303 bp
  • A to G, chromosome 5 at 21,297,005 bp
  • A to T, chromosome 5 at 86,667,584 bp
  • G to T, chromosome 7 at 30,576,692 bp
  • A to T, chromosome 7 at 35,787,770 bp
  • C to A, chromosome 7 at 44,885,890 bp
  • A to G, chromosome 8 at 99,400,718 bp
  • T to C, chromosome 8 at 117,040,739 bp
  • C to T, chromosome 10 at 27,001,235 bp
  • G to A, chromosome 10 at 33,468,195 bp
  • G to T, chromosome 10 at 34,152,474 bp
  • A to T, chromosome 10 at 79,527,813 bp
  • T to A, chromosome 10 at 83,570,002 bp
  • C to T, chromosome 11 at 43,706,188 bp
  • T to C, chromosome 11 at 58,965,233 bp
  • A to G, chromosome 11 at 82,444,330 bp
  • A to T, chromosome 11 at 83,069,564 bp
  • A to G, chromosome 11 at 86,328,622 bp
  • T to C, chromosome 12 at 85,049,870 bp
  • T to C, chromosome 13 at 113,078,699 bp
  • T to C, chromosome 14 at 7,942,057 bp
  • A to T, chromosome 14 at 12,616,158 bp
  • C to T, chromosome 14 at 106,107,307 bp
  • T to A, chromosome 15 at 10,994,836 bp
  • A to T, chromosome 16 at 37,062,337 bp
  • T to C, chromosome 17 at 7,750,357 bp
  • G to A, chromosome 17 at 18,258,388 bp
  • G to A, chromosome 17 at 38,275,530 bp
  • A to G, chromosome 17 at 38,335,432 bp
  • A to G, chromosome 18 at 51,303,123 bp
  • G to T, chromosome 19 at 6,277,014 bp
  • A to G, chromosome X at 75,267,424 bp
  • A to G, chromosome X at 96,290,816 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3436 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040654-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.