Strain Name:
C57BL/6J-MtgxR3983Btlr/Mmmh
Stock Number:
040944-MU
Citation ID:
RRID:MMRRC_040944-MU
Other Names:
R3983 (G1), C57BL/6J-MtgxR3983Btlr
Major Collection:

Strain Information

Mfap2
Name: microfibrillar-associated protein 2
Synonyms: Magp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17150
HGNC: HGNC:7033
Homologene: 1801
Sirt3
Name: sirtuin 3
Synonyms: Sir2l3, 2310003L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64384
Homologene: 81827
Kdm5b
Name: lysine demethylase 5B
Synonyms: Rb-Bp2, 2210016I17Rik, Jarid1b, 2010009J12Rik, D1Ertd202e, Plu1, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Cct2
Name: chaperonin containing TCP1 subunit 2
Synonyms: Cctb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, SR-AI, MRS-A, Scara1, MSR-A, Scvr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: Zak, MLTKbeta, B230120H23Rik, MLTKalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65964
Homologene: 32331
Mbnl1
Name: muscleblind like splicing regulator 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56758
HGNC: HGNC:6923
Homologene: 23186
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243385
Homologene: 52334
Twsg1
Name: twisted gastrulation BMP signaling modulator 1
Synonyms: D17Ertd403e, 1810013J15Rik, Tsg, 9030422N06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 65960
VEGA: 17
Homologene: 10774
Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
Synonyms: Acra2, Acra-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p160MBP, p67MBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68744
Homologene: 129530
Mme
Name: membrane metallo endopeptidase
Synonyms: neutral endopeptidase, NEP, neprilysin, 6030454K05Rik, CD10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Rnf44
Name: ring finger protein 44
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105239
Homologene: 8934
Ddx11
Name: DEAD/H box helicase 11
Synonyms: 4732462I11Rik, CHLR1, essa15a, KRG2, CHL1, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320209
VEGA: 17
Homologene: 68973
Hcrt
Name: hypocretin
Synonyms: orexin B, orexin A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15171
HGNC: HGNC:4847
Homologene: 1166
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Syn2
Name: synapsin II
Synonyms: Synapsin IIa, Synapsin IIb, 2900074L19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20965
Homologene: 49348
Epha5
Name: Eph receptor A5
Synonyms: Rek7, Cek7, bsk, Hek7, Ehk1, Els1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kcp
Name: kielin/chordin-like protein
Synonyms: Crim2, KCP, LOC333088
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Il1rl1
Name: interleukin 1 receptor-like 1
Synonyms: St2-rs1, T1/ST2, T1 gene, ST2, Fit-1, DER4, ST2L, St2, T1, Ly84
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17082
HGNC: HGNC:5998
Homologene: 2862
Mybpc3
Name: myosin binding protein C, cardiac
Synonyms: cardiac C-protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17868
HGNC: HGNC:7551
Homologene: 215
Rdh19
Name: retinol dehydrogenase 19
Synonyms: Rdhs, RDH-S
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216453
Homologene: 129514
Duxf4
Name: double homeobox family member 4
Synonyms: Duxf4, Gm4981
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 245263
Homologene: 134545
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Abcc6
Name: ATP-binding cassette, sub-family C member 6
Synonyms: Dyscalc1, Mrp6, DCC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114301
Homologene: 9804
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107141
Homologene: 137231
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98402
Homologene: 8726
Tbc1d4
Name: TBC1 domain family, member 4
Synonyms: 5930406J04Rik, AS160
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210789
Homologene: 45451
Or6f1
Name: olfactory receptor family 6 subfamily F member 1
Synonyms: GA_x6K02T2NHDJ-9786435-9787361, MOR104-1, Olfr308
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258614
Homologene: 27225
Or1e22
Name: olfactory receptor family 1 subfamily E member 22
Synonyms: Olfr381, GA_x6K02T2P1NL-3646409-3645474, MOR135-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259024
Eno3
Name: enolase 3, beta muscle
Synonyms: Eno-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13808
HGNC: HGNC:3354
Homologene: 68215
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Vmn1r90
Name: vomeronasal 1 receptor 90
Synonyms: B430211C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 627280
Homologene: 122945
Samhd1
Name: SAM domain and HD domain, 1
Synonyms: E330031J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56045
Homologene: 9160
Wee2
Name: WEE1 homolog 2 (S. pombe)
Synonyms: LOC381759, Wee1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381759
Homologene: 52392
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, gob-5, Clca3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70909
Homologene: 87049
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Gdap1
Name: ganglioside-induced differentiation-associated-protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14545
Homologene: 40713
1700093K21Rik
Name: RIKEN cDNA 1700093K21 gene
Synonyms: b2b3025Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67358
Homologene: 49849
Dcpp2
Name: demilune cell and parotid protein 2
Synonyms: EG630537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 630537
VEGA: 17
Homologene: 103921
Tcstv2a
Name: 2 cell stage variable group member 2A
Synonyms: clone L4 variable group of 2-cell-stage gene family, AF067061, clone L8 variable group of 2-cell-stage gene family
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 236546
Srcin1
Name: SRC kinase signaling inhibitor 1
Synonyms: p140Cap, P140
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56013
Homologene: 10324
Gm1587
Name: predicted gene 1587
Synonyms: LOC380920
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380920
VEGA: 14
Gm4876
Name: predicted gene 4876
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232599
Hoxa4
Name: homeobox A4
Synonyms: Hox-1.4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15401
HGNC: HGNC:5105
Homologene: 37583
Or12d15
Name: olfactory receptor family 12 subfamily D member 15
Synonyms: MOR250-7, GA_x6K02T2PSCP-1843460-1844386, Olfr105
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257893
Zak
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 17,159,907 bp
  • A to G, chromosome 1 at 40,446,663 bp
  • T to A, chromosome 1 at 46,233,711 bp
  • C to A, chromosome 1 at 75,422,547 bp
  • A to G, chromosome 1 at 89,145,869 bp
  • C to T, chromosome 1 at 134,631,304 bp
  • T to A, chromosome 2 at 11,480,058 bp
  • A to G, chromosome 2 at 19,542,369 bp
  • C to T, chromosome 2 at 72,438,227 bp
  • G to T, chromosome 2 at 76,802,361 bp
  • A to T, chromosome 2 at 91,135,369 bp
  • C to A, chromosome 2 at 157,123,449 bp
  • A to T, chromosome 3 at 60,603,696 bp
  • T to A, chromosome 3 at 63,328,064 bp
  • T to C, chromosome 3 at 116,923,823 bp
  • T to A, chromosome 3 at 144,755,309 bp
  • T to C, chromosome 4 at 43,553,030 bp
  • A to G, chromosome 4 at 141,014,243 bp
  • A to G, chromosome 5 at 84,233,809 bp
  • T to C, chromosome 5 at 104,521,023 bp
  • T to A, chromosome 6 at 17,099,701 bp
  • G to A, chromosome 6 at 29,442,941 bp
  • A to T, chromosome 6 at 29,484,637 bp
  • A to T, chromosome 6 at 40,455,241 bp
  • A to T, chromosome 6 at 52,190,677 bp
  • T to C, chromosome 6 at 59,354,560 bp
  • C to G, chromosome 6 at 115,237,298 bp
  • C to T, chromosome 7 at 23,984,809 bp
  • T to C, chromosome 7 at 45,995,289 bp
  • A to G, chromosome 7 at 86,321,734 bp
  • A to T, chromosome 7 at 140,878,112 bp
  • A to G, chromosome 8 at 39,620,018 bp
  • G to A, chromosome 8 at 43,650,769 bp
  • G to A, chromosome 8 at 110,392,325 bp
  • T to G, chromosome 10 at 45,590,364 bp
  • T to A, chromosome 10 at 58,235,801 bp
  • C to A, chromosome 10 at 77,088,887 bp
  • G to A, chromosome 10 at 117,054,135 bp
  • A to G, chromosome 10 at 127,850,148 bp
  • T to A, chromosome 11 at 23,517,220 bp
  • T to A, chromosome 11 at 70,661,411 bp
  • T to C, chromosome 11 at 72,447,170 bp
  • A to G, chromosome 11 at 73,486,135 bp
  • T to A, chromosome 11 at 75,661,499 bp
  • C to T, chromosome 11 at 83,390,716 bp
  • T to G, chromosome 11 at 97,525,553 bp
  • G to A, chromosome 11 at 100,761,853 bp
  • G to T, chromosome 11 at 106,347,818 bp
  • A to G, chromosome 12 at 117,728,670 bp
  • A to C, chromosome 13 at 54,683,148 bp
  • A to G, chromosome 13 at 109,740,406 bp
  • G to T, chromosome 13 at 120,264,279 bp
  • G to T, chromosome 14 at 66,149,457 bp
  • C to T, chromosome 14 at 77,794,843 bp
  • T to C, chromosome 14 at 101,507,213 bp
  • T to G, chromosome 15 at 98,846,046 bp
  • G to T, chromosome 15 at 102,208,243 bp
  • T to A, chromosome 17 at 23,900,573 bp
  • T to C, chromosome 17 at 37,383,398 bp
  • T to C, chromosome 17 at 65,929,763 bp
  • C to T, chromosome 17 at 66,134,130 bp
  • C to A, chromosome 18 at 34,637,486 bp
  • G to T, chromosome 19 at 40,046,255 bp
  • A to C, chromosome 19 at 40,113,518 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3983 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040944-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.