Strain Name:
C57BL/6J-MtgxR4192Btlr/Mmmh
Stock Number:
041023-MU
Citation ID:
RRID:MMRRC_041023-MU
Other Names:
R4192 (G1), C57BL/6J-MtgxR4192Btlr
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Add3
Name: adducin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 27360
VEGA: 19
HGNC: HGNC:245
Homologene: 40893
Dnajb9
Name: DnaJ heat shock protein family (Hsp40) member B9
Synonyms: microvascular endothelial differentiation gene, mDj7, Mdg1, ERdj4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27362
VEGA: 12
HGNC: HGNC:6968
Homologene: 32155
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: JNK-interacting protein 3, Jip3, JSAP1, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, sunday driver 2, Syd2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Fam185a
Name: family with sequence similarity 185, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330050
Homologene: 51828
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Vit
Name: vitrin
Synonyms: 1700110E08Rik, 1700052E02Rik, 2810429K11Rik, akhirin, AKH
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Itgam
Name: integrin alpha M
Synonyms: complement component receptor 3 alpha, CD11B (p170), Mac-1 alpha, Mac-1, complement receptor type 3, CR3, CD11b/CD18, Mac-1a, F730045J24Rik, Ly-40, Cd11b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Oca2
Name: oculocutaneous albinism II
Synonyms: D7H15S12, D7H15S12, p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
Synonyms: Gabra-2, C630048P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14395
HGNC: HGNC:4076
Homologene: 20217
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Angpt4
Name: angiopoietin 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11602
HGNC: HGNC:487
Homologene: 36302
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Pitpnm3
Name: PITPNM family member 3
Synonyms: A330068P14Rik, Ackr6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327958
Homologene: 66271
Vmn1r27
Name: vomeronasal 1 receptor 27
Synonyms: V1rc33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171206
Homologene: 79462
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Cbr2
Name: carbonyl reductase 2
Synonyms: MLCR, lung carbonyl reductase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12409
Homologene: 104184
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382014
Homologene: 124473
Scnn1b
Name: sodium channel, nonvoltage-gated 1 beta
Synonyms: ENaC beta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20277
Homologene: 133555
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192950
Homologene: 135717
Spata31f3
Name: spermatogenesis associated 31 subfamily F member 3
Synonyms: BC049635, Fam205c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277773
Homologene: 77625
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218921
Homologene: 138428
Rcc1l
Name: reculator of chromosome condensation 1 like
Synonyms: 5730496C04Rik, Wbscr16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94254
Homologene: 36477
Nkain3
Name: Na+/K+ transporting ATPase interacting 3
Synonyms: E130310K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269513
Homologene: 18265
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: 1700003B17Rik, 4732493F09Rik, p130
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Gm8369
Name: predicted gene 8369
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 666926
Or10d1c
Name: olfactory receptor family 10 subfamily D member 1C
Synonyms: GA_x6K02T2PVTD-32678895-32677963, MOR224-6, Olfr934
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258434
VEGA: 9
Homologene: 51730
Ube2q2l
Name: ubiquitin conjugating enzyme E2 Q2 like
Synonyms: E330021D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100502936
Rrm2
Name: ribonucleotide reductase M2
Synonyms: R2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20135
Homologene: 20277
4732463B04Rik
Name: RIKEN cDNA 4732463B04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
A930001C03Rik
Name: RIKEN cDNA A930001C03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319314
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 127,925,470 bp
  • C to T, chromosome 1 at 140,102,716 bp
  • T to A, chromosome 2 at 22,407,377 bp
  • T to A, chromosome 2 at 76,585,229 bp
  • G to T, chromosome 2 at 121,030,089 bp
  • A to C, chromosome 2 at 151,943,318 bp
  • G to A, chromosome 4 at 20,485,003 bp
  • A to T, chromosome 4 at 42,874,185 bp
  • A to G, chromosome 4 at 123,473,042 bp
  • T to A, chromosome 5 at 21,425,124 bp
  • G to A, chromosome 5 at 71,007,998 bp
  • T to C, chromosome 5 at 134,155,809 bp
  • A to C, chromosome 6 at 58,215,827 bp
  • A to G, chromosome 6 at 120,481,511 bp
  • T to C, chromosome 6 at 136,401,437 bp
  • T to C, chromosome 7 at 56,297,249 bp
  • T to G, chromosome 7 at 97,507,733 bp
  • A to G, chromosome 7 at 121,902,739 bp
  • A to G, chromosome 7 at 128,064,732 bp
  • A to T, chromosome 8 at 71,483,292 bp
  • T to A, chromosome 9 at 38,983,017 bp
  • A to T, chromosome 9 at 56,258,741 bp
  • T to C, chromosome 11 at 6,605,534 bp
  • T to C, chromosome 11 at 72,051,959 bp
  • C to A, chromosome 11 at 120,730,840 bp
  • T to C, chromosome 12 at 24,708,378 bp
  • A to T, chromosome 12 at 44,207,077 bp
  • T to C, chromosome 12 at 84,043,174 bp
  • C to A, chromosome 13 at 13,740,513 bp
  • G to T, chromosome 14 at 36,096,579 bp
  • T to C, chromosome 15 at 47,847,271 bp
  • A to G, chromosome 15 at 58,647,149 bp
  • A to T, chromosome 15 at 78,446,657 bp
  • C to T, chromosome 17 at 24,901,519 bp
  • A to T, chromosome 17 at 46,479,247 bp
  • A to G, chromosome 17 at 78,586,826 bp
  • G to C, chromosome 18 at 37,763,541 bp
  • T to A, chromosome 19 at 4,447,681 bp
  • C to T, chromosome 19 at 11,502,232 bp
  • C to A, chromosome 19 at 53,242,524 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4192 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041023-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.