Strain Name:
C57BL/6J-MtgxR4392Btlr/Mmmh
Stock Number:
041127-MU
Citation ID:
RRID:MMRRC_041127-MU
Other Names:
R4392 (G1), C57BL/6J-MtgxR4392Btlr
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Gtf2i
Name: general transcription factor II I
Synonyms: BAP-135, 6030441I21Rik, TFII-I
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Sgpl1
Name: sphingosine phosphate lyase 1
Synonyms: D10Xrf456
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20397
Homologene: 2897
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 2310022G15Rik, 5033407O22Rik, 4833414K03Rik, CHAK1, LTRPC7, CHAK, TRP-PLIK, Ltpr7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Nomo1
Name: nodal modulator 1
Synonyms: Nomo, D7Ertd156e, PM5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211548
Homologene: 13810
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Bub3
Name: BUB3 mitotic checkpoint protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12237
HGNC: HGNC:1151
Homologene: 3470
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Lhx4
Name: LIM homeobox protein 4
Synonyms: Gsh4, Gsh-4, A330062J17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16872
Homologene: 56497
Hjurp
Name: Holliday junction recognition protein
Synonyms: 6430706D22Rik, A730008H23Rik, C330011F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26558
Homologene: 37972
Grwd1
Name: glutamate-rich WD repeat containing 1
Synonyms: WDR28
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101612
Homologene: 6644
Mideas
Name: mitotic deacetylase associated SANT domain protein
Synonyms: 9430029N19Rik, C130039O16Rik, Elmsan1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238317
Homologene: 19330
Prl
Name: prolactin
Synonyms: Prl, Prl1a1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19109
HGNC: HGNC:9445
Homologene: 732
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Usp2
Name: ubiquitin specific peptidase 2
Synonyms: B930035K21Rik, ubp41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53376
Homologene: 3098
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Mmrn2
Name: multimerin 2
Synonyms: EndoGlyx-1, Emilin3, ENDOGLYX1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, MyHC-eo, EO Myosin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Scube3
Name: signal peptide, CUB domain, EGF-like 3
Synonyms: D030038I21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268935
Homologene: 65059
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: 1190005F20Rik, Trm1-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98685
Homologene: 12801
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: Prss7, enterokinase, A130097D21Rik, enteropeptidase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: Adrbk-2, beta ARK2, Adrbk2, 4833444A01Rik, Bark-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: Ugt1a6, UGT1.6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94284
Homologene: 85959
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Foxc2
Name: forkhead box C2
Synonyms: MFH-1, Fkh14, Hfhbf3, Mfh1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14234
HGNC: HGNC:3801
Homologene: 21091
Slc10a1
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms: Ntcp, sodium bile acid cotransporting polypeptide
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20493
VEGA: 12
Homologene: 31126
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268670
VEGA: 13
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: 9530008N10Rik, experimental autoimmune prostatitis antigen 1, Eapa1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Ift56
Name: intraflagellar transport 56
Synonyms: hydrocephalic-polydactyl, hop, hpy, Ttc26, 9430097H08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 264134
Homologene: 11786
Sstr5
Name: somatostatin receptor 5
Synonyms: Smstr5, sst5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20609
VEGA: 17
Homologene: 20287
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Clec12a
Name: C-type lectin domain family 12, member a
Synonyms: Micl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232413
Homologene: 51378
Or4k15c
Name: olfactory receptor family 4 subfamily K member 15C
Synonyms: MOR246-4, GA_x6K02T2PMLR-5775299-5774334, Olfr726
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258313
Homologene: 44957
Brsk1
Name: BR serine/threonine kinase 1
Synonyms: SAD-B, LOC381979
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381979
Homologene: 57169
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13085
Homologene: 69128
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66753
Homologene: 9247
Nkain3
Name: Na+/K+ transporting ATPase interacting 3
Synonyms: E130310K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269513
Homologene: 18265
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58186
Homologene: 48572
Amy2b
Name: amylase 2b
Synonyms: Amy-X, Amy2-2, mAmy2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545562
Esp34
Name: exocrine gland secreted peptide 34
Synonyms: Gm20410
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126773
Vopp1
Name: vesicular, overexpressed in cancer, prosurvival protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232023
Homologene: 12772
Gvin-ps3
Name: GTPase, very large interferon inducible, pseudogene 3
Synonyms: Gm8979, Gm21884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668108
Or4f7d-ps1
Name: olfactory receptor family 4 subfamily F member 7D, pseudogene 1
Synonyms: Olfr268-ps1, MOR245-17P, GA_x6K02T2N82Q-12713-13766, Gm13931
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668825
Homologene: 138901
Gm20528
Name: predicted gene 20528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Nxph2
Name: neurexophilin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18232
HGNC: HGNC:8076
Homologene: 7454
Cdrt4
Name: CMT1A duplicated region transcript 4
Synonyms: 1700019I23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66338
Homologene: 52147
Gm21738
Name: predicted gene, 21738
Type: Gene
Species: Mouse
Chromosome: 14
Gm24705
Name: predicted gene, 24705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Esp24
Name: exocrine gland secreted peptide 24
Synonyms: Gm21947
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126776
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 54,735,034 bp
  • CAGAGAGAGAGAGA to CAGAGAGAGAGA, chromosome 1 at 88,211,984 bp
  • C to T, chromosome 1 at 88,215,123 bp
  • C to T, chromosome 1 at 88,259,589 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • T to C, chromosome 1 at 151,440,844 bp
  • A to G, chromosome 1 at 155,710,134 bp
  • A to C, chromosome 2 at 23,400,272 bp
  • T to C, chromosome 2 at 111,844,345 bp
  • A to T, chromosome 2 at 126,795,509 bp
  • A to T, chromosome 2 at 126,848,538 bp
  • T to C, chromosome 2 at 128,676,249 bp
  • T to G, chromosome 2 at 172,916,542 bp
  • T to G, chromosome 3 at 113,149,408 bp
  • C to A, chromosome 4 at 20,282,985 bp
  • A to G, chromosome 5 at 35,032,311 bp
  • A to G, chromosome 5 at 112,920,136 bp
  • T to C, chromosome 5 at 134,260,629 bp
  • A to G, chromosome 6 at 38,381,557 bp
  • A to C, chromosome 6 at 57,762,476 bp
  • A to T, chromosome 6 at 112,693,529 bp
  • C to T, chromosome 6 at 124,230,176 bp
  • A to T, chromosome 6 at 129,353,464 bp
  • T to A, chromosome 7 at 4,698,750 bp
  • T to A, chromosome 7 at 27,029,275 bp
  • T to C, chromosome 7 at 27,418,471 bp
  • C to T, chromosome 7 at 45,827,780 bp
  • C to T, chromosome 7 at 46,058,480 bp
  • T to C, chromosome 7 at 46,285,124 bp
  • T to C, chromosome 7 at 106,082,965 bp
  • C to T, chromosome 7 at 131,566,335 bp
  • T to C, chromosome 8 at 33,251,832 bp
  • G to A, chromosome 8 at 70,290,143 bp
  • T to C, chromosome 8 at 121,117,452 bp
  • A to T, chromosome 9 at 44,091,259 bp
  • T to A, chromosome 9 at 55,858,115 bp
  • T to A, chromosome 9 at 79,662,488 bp
  • T to C, chromosome 9 at 86,503,143 bp
  • A to G, chromosome 9 at 107,400,280 bp
  • T to A, chromosome 9 at 109,568,232 bp
  • C to T, chromosome 9 at 123,066,752 bp
  • A to G, chromosome 10 at 61,104,452 bp
  • A to C, chromosome 11 at 9,309,034 bp
  • A to G, chromosome 11 at 30,943,697 bp
  • A to T, chromosome 11 at 62,951,353 bp
  • A to C, chromosome 11 at 67,344,881 bp
  • T to A, chromosome 11 at 77,090,458 bp
  • C to A, chromosome 12 at 80,967,804 bp
  • A to T, chromosome 12 at 84,173,111 bp
  • A to G, chromosome 13 at 27,064,351 bp
  • T to A, chromosome 13 at 67,139,643 bp
  • A to T, chromosome 14 at 12,142,467 bp
  • G to C, chromosome 14 at 19,417,178 bp
  • T to A, chromosome 14 at 34,397,616 bp
  • A to G, chromosome 14 at 50,084,603 bp
  • C to T, chromosome 14 at 54,584,978 bp
  • G to A, chromosome 15 at 28,289,229 bp
  • T to C, chromosome 15 at 100,162,036 bp
  • T to A, chromosome 15 at 102,086,641 bp
  • A to G, chromosome 16 at 79,024,438 bp
  • T to C, chromosome 17 at 25,491,224 bp
  • C to T, chromosome 17 at 28,164,788 bp
  • T to C, chromosome 17 at 29,850,656 bp
  • T to C, chromosome 17 at 38,559,491 bp
  • T to C, chromosome 17 at 39,040,077 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041127-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.