Strain Name:
C57BL/6J-MtgxR4125Btlr/Mmmh
Stock Number:
041633-MU
Citation ID:
RRID:MMRRC_041633-MU
Other Names:
R4125 (G1), C57BL/6J-MtgxR4125Btlr
Major Collection:

Strain Information

Cds2
Name: CDP-diacylglycerol synthase 2
Synonyms: D2Wsu127e, 5730460C18Rik, 5730450N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Cdk19
Name: cyclin dependent kinase 19
Synonyms: Cdc2l6, 2700084L06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78334
VEGA: 10
Homologene: 22862
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, 5730544L10Rik, C430013M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: IkappaB kinase alpha, IKK 1, IKK-alpha, IKK alpha, IKK[a], Chuk1, IKK1, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: KAT9, 2610507P14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
Synonyms: 1110037I22Rik, ALK3, Bmpr, BMPR-IA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12166
HGNC: HGNC:1076
Homologene: 20911
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: Rpo1-4, 3010014K16Rik, RPA194, 194kDa, mRPA1, 2900087K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Umps
Name: uridine monophosphate synthetase
Synonyms: 1700095D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22247
Homologene: 319
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 9330188B09Rik, D630001M17Rik, 4921513O20Rik, LOC381026
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Lman1
Name: lectin, mannose-binding, 1
Synonyms: gp58, MR60, 2610020P13Rik, P58, ERGIC53, MCFD1, F5F8D
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70361
HGNC: HGNC:6631
Homologene: 4070
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Adam30
Name: a disintegrin and metallopeptidase domain 30
Synonyms: 4933424D07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71078
HGNC: HGNC:208
Homologene: 11038
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Thoc6
Name: THO complex 6
Synonyms: Wdr58, F830014G06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386612
Homologene: 11533
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6
Synonyms: b2b2182Clo, b2b2187.1Clo, ADAM-TS6, b2b1879.1Clo, A930019D11Rik, b2b2029Clo, b2b2228Clo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, Munc13-3, 1500037O19Rik, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 272158
Homologene: 131253
Pcdhb13
Name: protocadherin beta 13
Synonyms: Pcdbh6, PcdhbM
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Bbox1
Name: gamma-butyrobetaine hydroxylase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170442
HGNC: HGNC:964
Homologene: 2967
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Rhof
Name: ras homolog family member F (in filopodia)
Synonyms: Ifld1, Arhf
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23912
Homologene: 41304
Vmn1r210
Name: vomeronasal 1 receptor 210
Synonyms: V1rh10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171269
Homologene: 110880
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20840
Homologene: 2371
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Lvrn
Name: laeverin
Synonyms: Aqpep, 4833403I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74574
VEGA: 18
Homologene: 51352
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74149
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Gramd2b
Name: GRAM domain containing 2B
Synonyms: Gramd3, 9030613F08Rik, 9130427A09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107022
VEGA: 18
Homologene: 32570
Myrip
Name: myosin VIIA and Rab interacting protein
Synonyms: A230081N12Rik, Slac2-c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245049
Homologene: 9150
Gnas
Name: GNAS complex locus
Synonyms: Galphas, Oedsml, Nespl, Gnas1, XLalphas, Nesp, G alpha s, SCG6, neuroendocrine-specific Golgi protein p55 isoform 1, Gs alpha, Gs-alpha, Gsa, P1, P3, Nesp55, P2, Gnasxl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Ctrc
Name: chymotrypsin C
Synonyms: caldecrin, 1810044E12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76701
HGNC: HGNC:2523
Homologene: 21422
Or52ae9
Name: olfactory receptor family 52 subfamily AE member 9
Synonyms: Olfr629, GA_x6K02T2PBJ9-6466772-6465828, MOR26-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258818
Homologene: 105159
Or14j8
Name: olfactory receptor family 14 subfamily J member 8
Synonyms: Olfr761, GA_x6K02T2PSCP-2403971-2403000, MOR218-6P, Olfr1552-ps1, MOR218-12, MOR218-5P, MOR218-6P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258094
Homologene: 134080
Ubash3a
Name: ubiquitin associated and SH3 domain containing, A
Synonyms: Sts-2, 5830413C03Rik, TULA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328795
Homologene: 56833
Slc22a12
Name: solute carrier family 22 (organic anion/cation transporter), member 12
Synonyms: Rst, URAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20521
Homologene: 56442
Tmem179
Name: transmembrane protein 179
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104885
VEGA: 12
Homologene: 16809
Ctsr
Name: cathepsin R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56835
VEGA: 13
Homologene: 75127
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Pvrl4, Prr4, 1200017F15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Gm23951
Name: predicted gene, 23951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 115485840
VEGA: 11
Ighj4
Name: immunoglobulin heavy joining 4
Synonyms: Gm16734
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 777656
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • T to C, chromosome 1 at 91,429,450 bp
  • T to A, chromosome 1 at 96,987,897 bp
  • A to G, chromosome 1 at 171,385,733 bp
  • A to G, chromosome 2 at 110,270,180 bp
  • A to G, chromosome 2 at 132,297,271 bp
  • A to G, chromosome 2 at 174,300,165 bp
  • A to G, chromosome 3 at 85,665,383 bp
  • T to A, chromosome 3 at 98,161,363 bp
  • C to T, chromosome 4 at 141,838,303 bp
  • C to T, chromosome 4 at 143,726,280 bp
  • A to G, chromosome 5 at 34,103,951 bp
  • C to T, chromosome 5 at 123,119,525 bp
  • A to G, chromosome 6 at 29,560,092 bp
  • G to T, chromosome 6 at 54,272,978 bp
  • T to C, chromosome 6 at 71,965,706 bp
  • T to C, chromosome 7 at 103,741,000 bp
  • A to T, chromosome 7 at 125,647,450 bp
  • A to G, chromosome 8 at 91,051,284 bp
  • A to C, chromosome 9 at 53,450,621 bp
  • A to G, chromosome 9 at 73,574,007 bp
  • C to A, chromosome 9 at 111,604,058 bp
  • C to A, chromosome 9 at 120,464,698 bp
  • A to G, chromosome 10 at 40,394,395 bp
  • A to T, chromosome 10 at 116,353,849 bp
  • A to G, chromosome 11 at 83,365,645 bp
  • A to T, chromosome 12 at 112,511,027 bp
  • T to C, chromosome 12 at 113,428,556 bp
  • A to T, chromosome 13 at 22,827,609 bp
  • A to T, chromosome 13 at 61,161,845 bp
  • A to T, chromosome 13 at 104,312,904 bp
  • T to C, chromosome 14 at 34,434,733 bp
  • C to T, chromosome 14 at 50,843,734 bp
  • T to C, chromosome 14 at 65,560,181 bp
  • A to T, chromosome 15 at 76,172,762 bp
  • T to C, chromosome 15 at 91,815,483 bp
  • G to T, chromosome 15 at 98,531,755 bp
  • G to A, chromosome 16 at 33,956,918 bp
  • A to T, chromosome 17 at 12,702,254 bp
  • C to T, chromosome 17 at 22,454,567 bp
  • A to T, chromosome 17 at 23,669,345 bp
  • T to C, chromosome 17 at 31,237,275 bp
  • A to G, chromosome 17 at 37,952,790 bp
  • T to C, chromosome 18 at 37,443,820 bp
  • C to A, chromosome 18 at 46,876,969 bp
  • T to C, chromosome 18 at 56,485,224 bp
  • C to A, chromosome 18 at 60,819,601 bp
  • T to C, chromosome 18 at 65,987,861 bp
  • T to C, chromosome 19 at 6,538,788 bp
  • T to A, chromosome 19 at 34,594,788 bp
  • T to C, chromosome 19 at 44,100,174 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041633-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.