Strain Name:
C57BL/6J-MtgxR4491Btlr/Mmmh
Stock Number:
041747-MU
Citation ID:
RRID:MMRRC_041747-MU
Other Names:
R4491 (G1), C57BL/6J-MtgxR4491Btlr
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: 5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319582
Homologene: 35306
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, 4930537L06Rik, Pdzk3, A930022H17Rik, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: 68kDa, TAFII68, 2610111C21Rik, Taf2n
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70439
Homologene: 131088
Nomo1
Name: nodal modulator 1
Synonyms: Nomo, D7Ertd156e, PM5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211548
Homologene: 13810
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Bzw1
Name: basic leucine zipper and W2 domains 1
Synonyms: 1200015E15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66882
Homologene: 41651
Dmtf1
Name: cyclin D binding myb like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23857
Homologene: 8017
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: Grf2, 4932418O06Rik, C3G
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: A730020P05Rik, sema, Sema6A-1, VIa, Semaq
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20358
Homologene: 32426
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22696
Homologene: 40682
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: 2700063L20Rik, Band 8A, 2610043M05Rik, D12Bwg0916e, B56/PP2A gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Ubxn10
Name: UBX domain protein 10
Synonyms: Ubxd3, 5730509E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212190
Homologene: 17568
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83379
Homologene: 12820
C030017K20Rik
Name: RIKEN cDNA C030017K20 gene
Synonyms: LOC381581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Zfp648
Name: zinc finger protein 648
Synonyms: LOC207678, Gm10178
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100503355
Homologene: 18996
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: 1200008N06Rik, mSYD1A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Cdh5
Name: cadherin 5
Synonyms: 7B4/cadherin-5, VE-Cad, VEcad, VE-cadherin, CD144, VECD, VEC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Rasal3
Name: RAS protein activator like 3
Synonyms: A430107D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320484
Homologene: 18901
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Tmem30a
Name: transmembrane protein 30A
Synonyms: D9Wsu20e, 2010200I23Rik, Cdc50a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69981
Homologene: 110703
Elmod3
Name: ELMO/CED-12 domain containing 3
Synonyms: Rbed1, ELMOD3, C330008I15Rik, RBM29
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232089
Homologene: 12978
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Hbb-bh2
Name: hemoglobin beta, bh2
Synonyms: Gm5736
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436003
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Or56a5
Name: olfactory receptor family 56 subfamily A member 5
Synonyms: Olfr683, GA_x6K02T2PBJ9-7773007-7772066, MOR40-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259047
Homologene: 133645
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76261
Homologene: 49537
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330450
Homologene: 69247
Or10ag60
Name: olfactory receptor family 10 subfamily AG member 60
Synonyms: MOR264-4, GA_x6K02T2Q125-49112575-49113519, Olfr1130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258835
Homologene: 133705
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Or7a37
Name: olfactory receptor family 7 subfamily A member 37
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2, Olfr1353
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259044
Homologene: 131345
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: LRG-47, Iigp3, Irgm, Ifi1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15944
Homologene: 134089
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74419
Homologene: 69456
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171241
Homologene: 44234
Igsf5
Name: immunoglobulin superfamily, member 5
Synonyms: Jam4, 2010003D20Rik, Igsf5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72058
HGNC: HGNC:5952
Homologene: 12437
Pou2af3
Name: POU class 2 homeobox associating factor 3
Synonyms: Colca2, OCA-T2, Gm684, LOC270157
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100502940
VEGA: 9
Homologene: 19023
Rptn
Name: repetin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20129
Homologene: 84780
Taf1
Name: TATA-box binding protein associated factor 1
Synonyms: KAT4, Ccg1, Taf2a, Ccg-1, B430306D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 270627
Homologene: 37942
Ighv7-2
Name: immunoglobulin heavy variable 7-2
Synonyms: Gm16699
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780800
HGNC: HGNC:5633
Defb6
Name: defensin beta 6
Synonyms: mBD-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 116746
Gm14193
Name: predicted gene 14193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,162,263 bp
  • T to A, chromosome 1 at 58,404,259 bp
  • T to G, chromosome 1 at 154,205,127 bp
  • C to T, chromosome 2 at 29,719,656 bp
  • G to A, chromosome 2 at 87,607,392 bp
  • T to C, chromosome 2 at 90,752,968 bp
  • G to T, chromosome 2 at 156,522,168 bp
  • A to G, chromosome 2 at 172,249,203 bp
  • G to T, chromosome 2 at 178,374,985 bp
  • T to C, chromosome 3 at 63,740,739 bp
  • G to A, chromosome 3 at 87,990,233 bp
  • A to T, chromosome 3 at 93,396,511 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 4 at 62,192,128 bp
  • A to C, chromosome 4 at 73,734,503 bp
  • G to A, chromosome 4 at 88,359,905 bp
  • T to C, chromosome 4 at 103,066,399 bp
  • T to C, chromosome 4 at 138,734,408 bp
  • T to C, chromosome 4 at 155,429,171 bp
  • A to G, chromosome 5 at 9,140,379 bp
  • C to A, chromosome 5 at 63,898,469 bp
  • A to G, chromosome 5 at 65,375,794 bp
  • T to C, chromosome 6 at 42,360,666 bp
  • T to C, chromosome 6 at 72,587,620 bp
  • A to G, chromosome 6 at 91,989,299 bp
  • T to C, chromosome 6 at 148,173,409 bp
  • C to A, chromosome 7 at 11,880,982 bp
  • A to G, chromosome 7 at 46,083,650 bp
  • T to C, chromosome 7 at 103,840,415 bp
  • A to T, chromosome 7 at 105,143,776 bp
  • A to T, chromosome 8 at 19,228,074 bp
  • G to A, chromosome 8 at 36,505,606 bp
  • T to C, chromosome 8 at 66,512,012 bp
  • A to T, chromosome 8 at 104,113,040 bp
  • A to G, chromosome 9 at 51,270,655 bp
  • C to T, chromosome 9 at 67,910,193 bp
  • T to C, chromosome 9 at 79,777,285 bp
  • C to T, chromosome 9 at 105,940,012 bp
  • C to T, chromosome 10 at 78,590,228 bp
  • T to C, chromosome 10 at 78,970,317 bp
  • T to C, chromosome 10 at 115,470,596 bp
  • G to A, chromosome 11 at 48,866,128 bp
  • A to T, chromosome 11 at 83,484,694 bp
  • T to A, chromosome 11 at 99,730,313 bp
  • A to G, chromosome 11 at 102,674,920 bp
  • A to T, chromosome 12 at 110,580,522 bp
  • A to G, chromosome 12 at 113,912,480 bp
  • T to C, chromosome 14 at 26,734,603 bp
  • C to T, chromosome 15 at 12,385,637 bp
  • A to C, chromosome 15 at 76,597,722 bp
  • A to G, chromosome 16 at 96,364,081 bp
  • T to A, chromosome 17 at 32,391,385 bp
  • T to C, chromosome 18 at 20,001,865 bp
  • G to A, chromosome 18 at 47,306,457 bp
  • A to G, chromosome 19 at 14,454,865 bp
  • A to C, chromosome 19 at 33,721,700 bp
  • G to T, chromosome X at 101,543,059 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4491 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.