Strain Name:
C57BL/6J-MtgxR4592Btlr/Mmmh
Stock Number:
041808-MU
Citation ID:
RRID:MMRRC_041808-MU
Other Names:
R4592 (G1), C57BL/6J-MtgxR4592Btlr
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, 4932417H02Rik, Rap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74370
Homologene: 80210
Neurog3
Name: neurogenin 3
Synonyms: ngn3, Atoh5, bHLHa7, Math4B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11925
VEGA: 10
Homologene: 40692
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Eif4g2
Name: eukaryotic translation initiation factor 4, gamma 2
Synonyms: Nat1, DAP-5, Natm1, E130105L11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13690
HGNC: HGNC:3297
Homologene: 37477
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, Tara, EST478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Esrrb
Name: estrogen related receptor, beta
Synonyms: Estrrb, ERRb, ERR2, Err2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26380
HGNC: HGNC:3473
Homologene: 69108
Skp1
Name: S-phase kinase-associated protein 1
Synonyms: 2610043E24Rik, 2610206H23Rik, p19Skp1, Tceb1l, Skp1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21402
Homologene: 38775
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Ddx52
Name: DExD box helicase 52
Synonyms: ROK1, 2700029C06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78394
Homologene: 5093
Vdac1
Name: voltage-dependent anion channel 1
Synonyms: Vdac5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22333
Homologene: 107244
Rbck1
Name: RanBP-type and C3HC4-type zinc finger containing 1
Synonyms: Ubce7ip3, HOIL-1L, HOIL-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24105
Homologene: 32448
Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
Synonyms: Eps15R, 9830147J04Rik, Eps15-rs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13859
Homologene: 31881
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Enpp6
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms: B830047L21Rik, D8Ertd514e, 4833421B01Rik, Npp6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320981
Homologene: 62657
Cxcl14
Name: C-X-C motif chemokine ligand 14
Synonyms: MIP-2g, Kec, BRAK, 1200006I23Rik, Scyb14, 1110031L23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 57266
VEGA: 13
Homologene: 3592
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Srsf6
Name: serine and arginine-rich splicing factor 6
Synonyms: 1210001E11Rik, Sfrs6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67996
Homologene: 110783
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: CD135, Flk-2, Flt-3, Flk2, wmfl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245038
Homologene: 70580
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: Clc2, ClC-2, nmf240
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, Cyp4a, D4Rp1, Msp-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, SPACR, A930015H12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: PACE4, SPC4, b2b2830Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13090
HGNC: HGNC:2615
Homologene: 104114
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Guf1
Name: GUF1 homolog, GTPase
Synonyms: mtEF4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231279
Homologene: 6505
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Or4a69
Name: olfactory receptor family 4 subfamily A member 69
Synonyms: GA_x6K02T2Q125-50926215-50925271, MOR231-14, Olfr1241
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258447
Homologene: 74067
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: 1500001J14Rik, BAF60C, 2210409C08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66993
Homologene: 2314
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Tmf1
Name: TATA element modulatory factor 1
Synonyms: LOC232286, 7030402D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232286
Homologene: 133801
Cfap119
Name: cilia and flagella associated protein 119
Synonyms: LOC233899, Gm166, Ccdc189
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233899
Homologene: 79950
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
4933430I17Rik
Name: RIKEN cDNA 4933430I17 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214106
Homologene: 51897
Stom
Name: stomatin
Synonyms: stomatin, protein 7.2b, Epb7.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glur-6, Glur6, Glurbeta2, C130030K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Or51h1
Name: olfactory receptor family 51 subfamily H member 1
Synonyms: GA_x6K02T2PBJ9-5375442-5376389, MOR10-1, Olfr555
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259107
Homologene: 51817
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22626
Homologene: 65865
Or5k17
Name: olfactory receptor family 5 subfamily K member 17
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4, Olfr181
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259001
Homologene: 74112
Zeb1os1
Name: zinc finger E-box binding homeobox 1, opposite strand 1
Synonyms: Zeb1os, Gm10125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 791318
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: 1700003B17Rik, 4732493F09Rik, p130
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50524
Homologene: 9269
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Or10v1
Name: olfactory receptor family 10 subfamily V member 1
Synonyms: GA_x6K02T2RE5P-2247227-2248156, MOR266-4, Olfr1420
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258405
Homologene: 17234
Spmap1
Name: sperm microtubule associated protein 1
Synonyms: 1700001P01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72215
Homologene: 19140
Gm26996
Name: predicted gene, 26996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
RP23-19A13.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm13415
Name: predicted gene 13415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102638285
Gm13563
Name: predicted gene 13563
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm21970
Name: predicted gene 21970
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 63,306,591 bp
  • T to G, chromosome 1 at 75,128,556 bp
  • C to A, chromosome 1 at 127,925,259 bp
  • G to A, chromosome 1 at 189,679,033 bp
  • T to A, chromosome 2 at 24,443,189 bp
  • C to A, chromosome 2 at 26,388,897 bp
  • T to C, chromosome 2 at 30,415,366 bp
  • T to C, chromosome 2 at 32,336,011 bp
  • C to T, chromosome 2 at 35,323,746 bp
  • T to A, chromosome 2 at 89,482,756 bp
  • T to A, chromosome 2 at 104,233,479 bp
  • T to C, chromosome 2 at 130,999,130 bp
  • G to A, chromosome 2 at 152,318,733 bp
  • T to C, chromosome 2 at 158,546,709 bp
  • T to C, chromosome 2 at 162,931,723 bp
  • A to T, chromosome 3 at 108,858,902 bp
  • T to C, chromosome 3 at 157,208,386 bp
  • A to T, chromosome 4 at 58,084,028 bp
  • T to A, chromosome 4 at 62,538,927 bp
  • A to G, chromosome 4 at 84,971,182 bp
  • T to A, chromosome 4 at 115,529,493 bp
  • C to T, chromosome 4 at 137,518,940 bp
  • T to C, chromosome 5 at 24,592,804 bp
  • T to C, chromosome 5 at 69,566,443 bp
  • T to A, chromosome 5 at 72,269,273 bp
  • A to T, chromosome 5 at 147,354,699 bp
  • C to T, chromosome 6 at 97,173,400 bp
  • T to A, chromosome 6 at 130,578,964 bp
  • T to A, chromosome 6 at 130,579,485 bp
  • A to G, chromosome 6 at 141,459,216 bp
  • A to G, chromosome 7 at 26,771,394 bp
  • A to C, chromosome 7 at 27,325,183 bp
  • A to C, chromosome 7 at 65,931,732 bp
  • T to G, chromosome 7 at 86,166,286 bp
  • T to A, chromosome 7 at 87,004,111 bp
  • A to C, chromosome 7 at 102,659,478 bp
  • T to C, chromosome 7 at 111,078,302 bp
  • C to T, chromosome 7 at 127,585,491 bp
  • G to T, chromosome 8 at 47,093,032 bp
  • T to C, chromosome 8 at 72,341,394 bp
  • T to C, chromosome 9 at 5,352,923 bp
  • A to G, chromosome 9 at 53,633,727 bp
  • T to A, chromosome 9 at 80,440,854 bp
  • T to C, chromosome 9 at 111,467,895 bp
  • A to T, chromosome 10 at 49,422,615 bp
  • A to G, chromosome 10 at 62,133,820 bp
  • T to C, chromosome 11 at 52,243,619 bp
  • G to A, chromosome 11 at 52,374,972 bp
  • T to C, chromosome 11 at 83,957,480 bp
  • A to G, chromosome 11 at 97,771,615 bp
  • A to G, chromosome 11 at 119,798,840 bp
  • A to G, chromosome 12 at 86,518,830 bp
  • A to T, chromosome 13 at 56,295,895 bp
  • C to T, chromosome 13 at 65,036,060 bp
  • G to A, chromosome 14 at 14,778,850 bp
  • C to A, chromosome 14 at 52,313,803 bp
  • T to A, chromosome 15 at 4,918,290 bp
  • C to T, chromosome 15 at 78,967,095 bp
  • T to C, chromosome 16 at 20,709,142 bp
  • T to C, chromosome 16 at 58,926,092 bp
  • T to C, chromosome 16 at 91,391,796 bp
  • T to C, chromosome 18 at 5,525,375 bp
  • T to C, chromosome 19 at 11,896,762 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041808-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.