Strain Name:
C57BL/6J-MtgxR4746Btlr/Mmmh
Stock Number:
041968-MU
Citation ID:
RRID:MMRRC_041968-MU
Other Names:
R4746 (G1), C57BL/6J-MtgxR4746Btlr
Major Collection:

Strain Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 4933415H02Rik, Trb, 5830465M17Rik, Che-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: MTGR1, C330013D05Rik, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Ppp2r3c
Name: protein phosphatase 2, regulatory subunit B'', gamma
Synonyms: 5730412A08Rik, G4-1, G5pr, 4930511A21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59032
VEGA: 12
Homologene: 9915
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Elavl2
Name: ELAV like RNA binding protein 1
Synonyms: mel-N1, Hub
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15569
HGNC: HGNC:3313
Homologene: 20930
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Gnb1
Name: guanine nucleotide binding protein (G protein), beta 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14688
HGNC: HGNC:4396
Homologene: 55532
Cfap20
Name: cilia and flagella associated protein 20
Synonyms: T10-2A2, 2600014O15Rik, Gtl3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14894
Homologene: 7350
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77031
Homologene: 75041
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Polr1has
Name: RNA polymerase I subunit H, antisense
Synonyms: 1700022C21Rik, Znrd1as
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76416
Homologene: 130062
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Atp5f1a
Name: ATP synthase F1 subunit alpha
Synonyms: Atpm, D18Ertd206e, Mom2, Atp5a1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11946
HGNC: HGNC:823
Homologene: 2985
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
Dsp
Name: desmoplakin
Synonyms: 2300002E22Rik, DP, 5730453H04Rik, rul
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Lrrc55
Name: leucine rich repeat containing 55
Synonyms: LOC241528, A330097E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241528
VEGA: 2
Homologene: 19385
Mia3
Name: MIA SH3 domain ER export factor 3
Synonyms: LOC385255, Tango, A930039G15Rik, B230399H06Rik, 9130229H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 338366
Homologene: 85165
Cxcl13
Name: C-X-C motif chemokine ligand 13
Synonyms: BCA-1, BLC, Scyb13, ANGIE2, 4631412M08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55985
Homologene: 48431
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: CLIMP-63, P63, 5630400A09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240880
Homologene: 10706
Ulk3
Name: unc-51-like kinase 3
Synonyms: 1200015E14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71742
VEGA: 9
Homologene: 68482
Wfdc6b
Name: WAP four-disulfide core domain 6B
Synonyms: Wfdc6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433502
Homologene: 79014
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
Synonyms: 1100001I19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244745
Homologene: 14762
Folr1
Name: folate receptor alpha
Synonyms: FBP1, folate receptor [a], folate-binding protein 1, Folbp1, Folbp-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14275
HGNC: HGNC:3791
Homologene: 7322
Fbxo47
Name: F-box protein 47
Synonyms: LOC380724, 2900052P03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72973
Homologene: 47677
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: Rab11-FIP2, nRip11, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Or2t35
Name: olfactory receptor family 2 subfamily T member 35
Synonyms: GA_x6K02T2PLTE-6793523-6794528, MOR274-3P, MOR274-4_i, Olfr721
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 257982
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, 5830475I06Rik, Loh11cr2a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Kos1, Tnk1b, Tnk1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83813
Homologene: 2966
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: OSBP3, ORP3, 1200014M06Rik, 6720421I08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Rimklb
Name: ribosomal modification protein rimK-like family member B
Synonyms: 4931417E21Rik, 4933426K21Rik, NAAGS
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108653
Homologene: 18968
Megf11
Name: multiple EGF-like-domains 11
Synonyms: 2410080H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214058
Homologene: 13031
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56299
Homologene: 10529
Ocstamp
Name: osteoclast stimulatory transmembrane protein
Synonyms: 4833422F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74614
Homologene: 41768
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, LOC386531, Gm98
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Eif2b4
Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms: Eif2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13667
HGNC: HGNC:3260
Homologene: 5976
Pyroxd2
Name: pyridine nucleotide-disulphide oxidoreductase domain 2
Synonyms: 3830409H07Rik, 4833409A17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74580
VEGA: 19
Homologene: 13097
Klhl11
Name: kelch-like 11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217194
Homologene: 10030
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Gm17333
Name: predicted gene, 17333
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22626
Homologene: 65865
Or8b12
Name: olfactory receptor family 8 subfamily B member 12
Synonyms: GA_x6K02T2PVTD-31428850-31429782, MOR161-2, Olfr874
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258882
Homologene: 17377
Donson
Name: downstream neighbor of SON
Synonyms: Donson, 1110025J21Rik, ORF60
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 60364
HGNC: HGNC:2993
Homologene: 32350
Marchf3
Name: membrane associated ring-CH-type finger 3
Synonyms: 6330411I15Rik, A530081L18Rik, March3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 320253
Homologene: 35310
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Gnptg
Name: N-acetylglucosamine-1-phosphotransferase, gamma subunit
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214505
VEGA: 17
Homologene: 13047
Ydjc
Name: YdjC homolog (bacterial)
Synonyms: 4930521M19Rik, 1810015A11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69101
Homologene: 19062
Sowaha
Name: sosondowah ankyrin repeat domain family member A
Synonyms: A830006N08Rik, Ankrd43
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237761
Homologene: 18488
Gm6866
Name: predicted gene 6866
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628304
Homologene: 80005
Gm7135
Name: predicted gene 7135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 634346
Homologene: 86643
Gm22953
Name: predicted gene, 22953
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm15601
Name: predicted gene 15601
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 115488342
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • AGGTT to A, chromosome 1 at 75,133,315 bp
  • A to G, chromosome 1 at 97,415,147 bp
  • A to C, chromosome 1 at 105,585,024 bp
  • G to A, chromosome 1 at 163,949,251 bp
  • A to G, chromosome 1 at 172,114,840 bp
  • C to T, chromosome 1 at 178,873,981 bp
  • A to G, chromosome 1 at 183,345,220 bp
  • A to G, chromosome 2 at 31,905,614 bp
  • G to A, chromosome 2 at 85,196,170 bp
  • T to C, chromosome 2 at 121,450,688 bp
  • A to C, chromosome 2 at 154,523,925 bp
  • C to A, chromosome 2 at 164,617,433 bp
  • T to C, chromosome 2 at 165,396,288 bp
  • A to T, chromosome 2 at 167,441,170 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • A to G, chromosome 4 at 83,244,103 bp
  • A to T, chromosome 4 at 91,260,713 bp
  • A to G, chromosome 4 at 118,225,039 bp
  • C to A, chromosome 4 at 155,543,074 bp
  • A to G, chromosome 5 at 31,187,653 bp
  • A to G, chromosome 5 at 95,959,897 bp
  • C to T, chromosome 5 at 134,240,836 bp
  • A to G, chromosome 5 at 137,643,947 bp
  • T to C, chromosome 6 at 50,328,674 bp
  • A to T, chromosome 6 at 70,687,324 bp
  • A to C, chromosome 6 at 113,407,392 bp
  • G to A, chromosome 6 at 122,472,632 bp
  • G to A, chromosome 7 at 25,288,480 bp
  • G to T, chromosome 7 at 41,216,118 bp
  • T to A, chromosome 7 at 101,863,977 bp
  • T to C, chromosome 7 at 105,748,951 bp
  • T to A, chromosome 7 at 123,189,997 bp
  • A to T, chromosome 8 at 25,033,697 bp
  • A to G, chromosome 8 at 95,422,056 bp
  • C to A, chromosome 9 at 24,450,670 bp
  • G to T, chromosome 9 at 37,746,157 bp
  • A to T, chromosome 9 at 38,737,885 bp
  • A to T, chromosome 9 at 54,451,796 bp
  • G to A, chromosome 9 at 57,592,918 bp
  • A to C, chromosome 9 at 64,508,745 bp
  • C to T, chromosome 10 at 58,492,670 bp
  • A to G, chromosome 10 at 84,533,520 bp
  • A to T, chromosome 11 at 53,479,336 bp
  • A to G, chromosome 11 at 69,735,674 bp
  • A to G, chromosome 11 at 69,855,166 bp
  • G to A, chromosome 11 at 84,422,919 bp
  • A to T, chromosome 11 at 97,879,428 bp
  • A to T, chromosome 11 at 100,464,350 bp
  • A to T, chromosome 12 at 55,302,635 bp
  • T to C, chromosome 13 at 38,195,104 bp
  • A to T, chromosome 14 at 14,407,359 bp
  • A to T, chromosome 14 at 36,909,125 bp
  • T to C, chromosome 14 at 45,595,681 bp
  • A to G, chromosome 15 at 7,224,639 bp
  • A to C, chromosome 16 at 17,148,312 bp
  • AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA to AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA, chromosome 16 at 77,852,878 bp
  • A to C, chromosome 16 at 91,682,237 bp
  • ATTGTTGATGATTT to AT, chromosome 17 at 25,235,597 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to T, chromosome 17 at 36,964,873 bp
  • A to T, chromosome 18 at 56,776,072 bp
  • G to T, chromosome 18 at 77,778,742 bp
  • A to G, chromosome 19 at 10,218,591 bp
  • G to A, chromosome 19 at 42,752,400 bp
  • A to T, chromosome 19 at 44,088,771 bp
  • G to A, chromosome 19 at 59,937,110 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4746 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041968-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.