Strain Name:
LFSS/HdMmjax
Stock Number:
042047-JAX
Citation ID:
RRID:MMRRC_042047-JAX
Other Names:
L-FSS (low fear-sensitized startle) , D x H DBA/2J-congenic recombinant inbred

Strain Information

D13Mit147
Name: DNA segment, Chr 13, Massachusetts Institute of Technology 147
Type: Cytogenetic Marker
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Non-mutant
D13Mit291
Name: DNA Segment, Chr 13, Massachusetts Institute of Technology 291
Type: Cytogenetic Marker
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Non-mutant
D14Mit154
Name: DNA segment, Chr 14, Massachusetts Institute of Technology 154
Type: Cytogenetic Marker
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Non-mutant
D14Mit161
Name: DNA segment, Chr 14, Massachusetts Institute of Technology 161
Type: Cytogenetic Marker
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Non-mutant
Genetic Alterations
No inserted mutation. Recombinant inbred strain.
ES Cell Line
Not applicable
Phenotype

Less fearful control group for the high fear-sensitized startle (H-FSS) mice which show a consistent and robust fear-ful and stress-prone phenotype.

MeSH Terms
  • Acoustic Stimulation
  • Acute Disease
  • Animals
  • Behavior, Animal
  • Biogenic Monoamines/metabolism
  • Brain/metabolism
  • Corticosterone/blood
  • Disease Models, Animal
  • Extinction, Psychological
  • Fear
  • Genotype
  • Mental Recall
  • Mice, Inbred C3H
  • Mice, Inbred DBA
  • Phenotype
  • Reflex, Startle
  • Species Specificity
  • Stress, Psychological/blood
  • Stress, Psychological/genetics
  • Stress, Psychological/psychology
  • Swimming
  • Time Factors
Strain Development
Backcrossing for 6-9 generations and inbreeding for another 7 generations under behavioral selection pressure (altogether bred for 13-16 generations under behavioral selection pressure).
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact csmmrrc@jax.org. Older strains may not have this information.
  • Developmental Biology
  • Endocrine Deficiency
  • Neurobiology
  • Sensorineural
Donor
Yilmazer-Hanke [M.D.] [Ph.D.], Deniz
Primary Reference

Browne CA, Hanke J, Rose C, Walsh I, Foley T, Clarke G, Schwegler H, Cryan JF, Yilmazer-Hanke D. Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction. Stress. 2014 Dec;17(6):471-83. (Medline PMID: 25117886)

Colony and Husbandry Information

Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org.
Coat Color
DBA/2J fur color
MMRRC Breeding System
Sib-mating
Generation
6-9
Overall Breeding Performance
Good
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: >12 months > 12 months
Bred to Homozygosity
No
Average litter size
Less than 4
Recommended wean age
3-4 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042047-JAX-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
042047-JAX-RESUS Litter recovered from cryo-archive $2,022.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.