Strain Name:
C57BL/6J-MtgxR5507Btlr/Mmmh
Stock Number:
043068-MU
Citation ID:
RRID:MMRRC_043068-MU
Other Names:
R5507 (G1), C57BL/6J-MtgxR5507Btlr
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Chrnb4
Name: cholinergic receptor, nicotinic, beta polypeptide 4
Synonyms: Acrb-4, Acrb4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108015
VEGA: 9
HGNC: HGNC:1964
Homologene: 20196
Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Elavl4
Name: ELAV like RNA binding protein 4
Synonyms: Hud
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15572
HGNC: HGNC:3315
Homologene: 40729
Meis1
Name: Meis homeobox 1
Synonyms: C530044H18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17268
HGNC: HGNC:7000
Homologene: 86803
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Ruvbl1
Name: RuvB-like AAA ATPase 1
Synonyms: Pontin52, 2510009G06Rik, Tip49a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56505
Homologene: 37839
Ints12
Name: integrator complex subunit 12
Synonyms: A230056J18Rik, 4930529N21Rik, 2810027J24Rik, 1110020M19Rik, Phf22
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71793
Homologene: 32474
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Cntnap1
Name: contactin associated protein-like 1
Synonyms: p190, Caspr, Nrxn4, NCP1, paranodin, shm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Pam16
Name: presequence translocase-asssociated motor 16
Synonyms: CGI-136, 2010110I09Rik, Magmas, Tim16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66449
Homologene: 41100
Fcrl1
Name: Fc receptor-like 1
Synonyms: IFGP1, BXMAS1-like, Fcrh1, moFcRH1S, moFcRH1L, A230020G22Rik, moFcRH1, mIFGP1, mBXMH1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229499
Homologene: 50472
Galnt14
Name: polypeptide N-acetylgalactosaminyltransferase 14
Synonyms: 0610033M06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71685
Homologene: 56997
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: Ampd-2, 1200014F01Rik, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Gcdh
Name: glutaryl-Coenzyme A dehydrogenase
Synonyms: D17825
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270076
HGNC: HGNC:4189
Homologene: 130
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: 8-LOX, e-LOX1, Alox12-ps1, Aloxe, Alox12-ps2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11685
Homologene: 105868
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17876
Homologene: 69079
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Chga
Name: chromogranin A
Synonyms: ChrA
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12652
VEGA: 12
HGNC: HGNC:1929
Homologene: 976
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: Hh1, 9630005B12Rik, 5830411O09Rik, 8430421H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: 6030401B09Rik, Nt5c2l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66605
Homologene: 45135
Ephb1
Name: Eph receptor B1
Synonyms: Elk, Hek6, Net, Cek6, Elkh, C130099E04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: 1700055M05Rik, Vdu2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74270
Homologene: 4861
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433492
Homologene: 128535
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71609
Homologene: 2807
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: P-12LO, Alox12p, 9930022G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Krt77
Name: keratin 77
Synonyms: 4732484G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406220
Homologene: 45490
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
1700009N14Rik
Name: RIKEN cDNA 1700009N14 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75471
Homologene: 128450
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72925
Homologene: 113749
Taar7a
Name: trace amine-associated receptor 7A
Synonyms: LOC215856, Taar7a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215856
Homologene: 110833
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74121
Homologene: 75083
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: ORF25, 5830404H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56709
Homologene: 9749
Or5t9
Name: olfactory receptor family 5 subfamily T member 9
Synonyms: GA_x6K02T2Q125-48321457-48322449, MOR179-7, Olfr1094
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258362
Homologene: 133609
Xrcc2
Name: X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms: RecA, 4921524O04Rik, 8030409M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57434
Homologene: 3964
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: headpin, PI13, HURPIN, HUR7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Psg17
Name: pregnancy specific beta-1-glycoprotein 17
Synonyms: mmCGM5, Cea-2, Cea2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26437
HGNC: HGNC:1819
Homologene: 110989
Dppa5a
Name: developmental pluripotency associated 5A
Synonyms: Esg1, ecat2, Dppa5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434423
Homologene: 104905
Cct8l1
Name: chaperonin containing TCP1 subunit 8-like 1
Synonyms: LOC242891, Gm443
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242891
Homologene: 40943
Gm26919
Name: predicted gene, 26919
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Homologene: 134227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,889,280 bp
  • A to G, chromosome 1 at 106,998,602 bp
  • T to A, chromosome 1 at 149,922,080 bp
  • A to G, chromosome 1 at 160,351,328 bp
  • A to G, chromosome 1 at 181,135,036 bp
  • A to T, chromosome 2 at 31,010,226 bp
  • A to G, chromosome 2 at 31,988,176 bp
  • T to A, chromosome 2 at 86,829,317 bp
  • T to C, chromosome 2 at 113,841,678 bp
  • A to T, chromosome 2 at 125,116,703 bp
  • C to A, chromosome 2 at 127,008,898 bp
  • C to A, chromosome 2 at 127,884,474 bp
  • A to T, chromosome 2 at 154,317,027 bp
  • T to A, chromosome 3 at 83,033,336 bp
  • C to T, chromosome 3 at 87,391,242 bp
  • A to G, chromosome 3 at 108,077,613 bp
  • T to A, chromosome 3 at 133,109,160 bp
  • A to G, chromosome 4 at 39,451,084 bp
  • T to C, chromosome 4 at 110,213,206 bp
  • A to G, chromosome 5 at 3,968,683 bp
  • A to T, chromosome 5 at 25,516,379 bp
  • A to G, chromosome 5 at 25,692,319 bp
  • C to A, chromosome 5 at 64,953,406 bp
  • C to T, chromosome 5 at 121,281,101 bp
  • T to C, chromosome 6 at 3,373,898 bp
  • A to G, chromosome 6 at 88,467,600 bp
  • G to A, chromosome 6 at 130,675,979 bp
  • T to C, chromosome 7 at 18,819,926 bp
  • A to C, chromosome 7 at 26,384,719 bp
  • A to G, chromosome 7 at 46,261,699 bp
  • A to G, chromosome 7 at 46,775,841 bp
  • T to C, chromosome 7 at 141,807,832 bp
  • T to C, chromosome 8 at 66,418,890 bp
  • A to G, chromosome 8 at 84,892,857 bp
  • T to G, chromosome 8 at 105,259,625 bp
  • T to G, chromosome 9 at 55,035,012 bp
  • T to A, chromosome 9 at 78,368,071 bp
  • C to T, chromosome 9 at 101,936,116 bp
  • A to G, chromosome 10 at 4,106,432 bp
  • C to T, chromosome 10 at 11,166,509 bp
  • A to G, chromosome 10 at 23,992,631 bp
  • A to T, chromosome 10 at 34,397,230 bp
  • GC to G, chromosome 10 at 59,892,752 bp
  • A to T, chromosome 10 at 86,080,226 bp
  • T to C, chromosome 10 at 100,609,233 bp
  • A to T, chromosome 11 at 19,016,168 bp
  • T to C, chromosome 11 at 70,254,412 bp
  • A to T, chromosome 11 at 70,320,877 bp
  • G to C, chromosome 11 at 77,137,061 bp
  • A to T, chromosome 11 at 97,338,330 bp
  • A to G, chromosome 11 at 101,183,477 bp
  • T to A, chromosome 12 at 21,297,928 bp
  • T to C, chromosome 12 at 102,562,609 bp
  • T to A, chromosome 13 at 13,489,037 bp
  • A to C, chromosome 13 at 100,298,915 bp
  • A to T, chromosome 14 at 37,082,845 bp
  • T to A, chromosome 15 at 36,099,652 bp
  • T to C, chromosome 15 at 101,861,230 bp
  • G to T, chromosome 16 at 4,618,016 bp
  • T to C, chromosome 16 at 97,881,620 bp
  • T to A, chromosome 17 at 18,597,829 bp
  • A to G, chromosome 17 at 73,495,666 bp
  • G to A, chromosome 18 at 20,046,279 bp
  • T to A, chromosome 18 at 79,086,712 bp
  • T to C, chromosome 19 at 6,245,070 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5507 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043068-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.