Strain Name:
C57BL/6J-MtgxR5908Btlr/Mmmh
Stock Number:
044105-MU
Citation ID:
RRID:MMRRC_044105-MU
Other Names:
R5908 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: A430078G23Rik, D030053O22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: Fthfsdc1, 2410004L15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik, 2010203A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56484
Homologene: 31039
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, Skt, 9430077C05Rik, Etl-4, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77031
Homologene: 75041
Hip1
Name: huntingtin interacting protein 1
Synonyms: E130315I21Rik, HIP-1, 2610109B09Rik, A930014B11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 4732460C16Rik, TAF2B, TAFII150, 150kDa, CIF150
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Nhsl3
Name: NHS like 3
Synonyms: C77080
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97130
Homologene: 45837
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, Klkbp, 1A1, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Il36rn
Name: interleukin 36 receptor antagonist
Synonyms: IL1HY1, Il1f5, FIL1delta, IL-1H3, If36rn, IL1F5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54450
Homologene: 10453
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 0910001O23Rik, eIF2alpha, 2410026C18Rik, Eif2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: Arg1, androgen-regulated gene 1, Lcn7, 1110021J17Rik, AZ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 94242
Homologene: 41472
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: Nr2e1, tailless, Mtll, Tlx
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Or13n4
Name: olfactory receptor family 13 subfamily N member 4
Synonyms: GA_x6K02T2PBJ9-9202245-9201289, Olfr702, MOR260-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258590
Homologene: 121512
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Pnma8b
Name: PNMA family member 8B
Synonyms: EG434128, Pnmal2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57782
Homologene: 23287
Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
Synonyms: p55pik, p55
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18710
HGNC: HGNC:8981
Homologene: 2690
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98402
Homologene: 8726
Clip3
Name: CAP-GLY domain containing linker protein 3
Synonyms: 1500005P14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76686
Homologene: 9176
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: March10, 4933417C16Rik, Rnf190, OTTMUSG00000002847
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 632687
Homologene: 34988
Tor2a
Name: torsin family 2, member A
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30933
Homologene: 25260
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Gm4841
Name: predicted gene 4841
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225594
VEGA: 18
Polb
Name: polymerase (DNA directed), beta
Synonyms: A430088C08Rik, Pol beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18970
HGNC: HGNC:9174
Homologene: 2013
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
4933416C03Rik
Name: RIKEN cDNA 4933416C03 gene
Type: Gene
Species: Mouse
Chromosome: 10
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: PNPase, polynucleotide phosphorylase, 1200003F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71701
Homologene: 12404
Bcl2a1c
Name: B cell leukemia/lymphoma 2 related protein A1c
Synonyms: A1-c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12046
HGNC: HGNC:991
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73430
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Use1
Name: unconventional SNARE in the ER 1 homolog (S. cerevisiae)
Synonyms: Q-SNARE, 2010315L10Rik, D12, mED2, 5730403H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67023
Homologene: 10214
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404238
Homologene: 138632
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 1300018I17Rik, 2410004N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72325
Homologene: 21021
B9d2
Name: B9 protein domain 2
Synonyms: stumpy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232987
Homologene: 12733
Commd5
Name: COMM domain containing 5
Synonyms: 2310065H03Rik, D15Ertd81e, Hcarg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66398
Homologene: 8548
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Prl8a1
Name: prolactin family 8, subfamily a, member 1
Synonyms: Plpcd, PLP-Cd, Prlpc4, 3830403L08Rik, 1600017L04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73244
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 2610312F20Rik, 6332415K15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70461
Homologene: 11248
Btbd8
Name: BTB domain containing 8
Synonyms: Gm16115, EG627196, A830010M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503185
VEGA: 5
Homologene: 82388
Zfp36l1
Name: zinc finger protein 36, C3H type-like 1
Synonyms: cMG1, Brf1, TIS11b, D530020L18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12192
VEGA: 12
HGNC: HGNC:1107
Homologene: 31276
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
B230208B08Rik
Name: RIKEN cDNA B230208B08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 102634132
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 89,145,883 bp
  • G to A, chromosome 1 at 135,918,883 bp
  • C to T, chromosome 2 at 20,743,907 bp
  • G to T, chromosome 2 at 24,277,490 bp
  • A to G, chromosome 2 at 31,991,341 bp
  • T to C, chromosome 2 at 32,761,685 bp
  • A to G, chromosome 2 at 121,236,823 bp
  • C to T, chromosome 2 at 167,451,170 bp
  • T to C, chromosome 3 at 98,123,923 bp
  • A to G, chromosome 4 at 78,214,060 bp
  • A to T, chromosome 4 at 116,272,758 bp
  • A to G, chromosome 4 at 129,222,148 bp
  • G to T, chromosome 4 at 130,172,970 bp
  • A to T, chromosome 5 at 34,216,870 bp
  • T to G, chromosome 5 at 107,507,594 bp
  • A to G, chromosome 5 at 135,424,863 bp
  • T to G, chromosome 5 at 143,173,636 bp
  • C to A, chromosome 5 at 144,786,708 bp
  • G to A, chromosome 6 at 139,768,710 bp
  • C to T, chromosome 7 at 16,947,043 bp
  • T to A, chromosome 7 at 25,683,299 bp
  • T to C, chromosome 7 at 27,404,253 bp
  • T to A, chromosome 7 at 27,910,957 bp
  • C to A, chromosome 7 at 30,296,873 bp
  • A to T, chromosome 7 at 48,643,618 bp
  • T to A, chromosome 7 at 80,595,794 bp
  • T to C, chromosome 7 at 106,824,197 bp
  • G to A, chromosome 8 at 3,453,165 bp
  • A to T, chromosome 8 at 22,642,303 bp
  • G to C, chromosome 8 at 71,369,613 bp
  • A to T, chromosome 8 at 83,249,545 bp
  • G to T, chromosome 8 at 123,246,824 bp
  • A to G, chromosome 9 at 44,948,024 bp
  • C to G, chromosome 9 at 105,862,801 bp
  • A to G, chromosome 9 at 114,330,504 bp
  • T to C, chromosome 10 at 4,089,392 bp
  • T to C, chromosome 10 at 42,196,587 bp
  • T to C, chromosome 10 at 42,572,769 bp
  • C to G, chromosome 10 at 59,049,448 bp
  • A to G, chromosome 10 at 75,721,532 bp
  • A to T, chromosome 10 at 116,113,228 bp
  • A to G, chromosome 10 at 128,018,024 bp
  • T to A, chromosome 11 at 29,130,887 bp
  • A to G, chromosome 11 at 86,215,545 bp
  • C to T, chromosome 11 at 105,390,239 bp
  • T to A, chromosome 12 at 78,880,043 bp
  • A to T, chromosome 12 at 80,109,675 bp
  • T to C, chromosome 12 at 104,151,711 bp
  • T to A, chromosome 13 at 13,696,761 bp
  • A to G, chromosome 13 at 21,981,814 bp
  • T to A, chromosome 13 at 27,574,057 bp
  • T to C, chromosome 13 at 67,591,255 bp
  • C to A, chromosome 13 at 102,738,256 bp
  • A to G, chromosome 14 at 55,887,066 bp
  • G to A, chromosome 15 at 55,072,006 bp
  • A to T, chromosome 15 at 76,900,936 bp
  • T to A, chromosome 15 at 100,151,184 bp
  • C to T, chromosome 17 at 27,996,019 bp
  • A to T, chromosome 17 at 46,313,804 bp
  • A to G, chromosome 18 at 60,270,434 bp
  • T to C, chromosome 19 at 6,351,316 bp
  • A to T, chromosome 19 at 24,397,137 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5908 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044105-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.