Strain Name:
C57BL/6J-MtgxR6303Btlr/Mmmh
Stock Number:
044410-MU
Citation ID:
RRID:MMRRC_044410-MU
Other Names:
R6303 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: 1110048P06Rik, Npn-2, NP2, NP-2, Npn2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: Pp4r1, 3110001J10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Jhdm1b, Fbxl10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-gamma1, Plc-1, Plcg-1, Cded
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Phyhipl
Name: phytanoyl-CoA hydroxylase interacting protein-like
Synonyms: PHY2, 4921522K17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70911
Homologene: 13028
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA116, Rpo1-2, RPA2, 128kDa, D630020H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: ERdj5, 1200006L06Rik, JPDI, D2Ertd706e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66861
Homologene: 10358
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, 5330417C22Rik, Iir
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229722
Homologene: 23249
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: TAFII105, 105kDa, 2610524B04Rik, 4932409F03Rik, Taf2c2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100604
Homologene: 12997
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: 9830001H06Rik, Soga1, D430036N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: Olfr639, GA_x6K02T2PBJ9-6747143-6746193, MOR12-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, thd, Zp, zyklopen, cw
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Sik1
Name: salt inducible kinase 1
Synonyms: Snf1lk, Msk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17691
VEGA: 17
Homologene: 7847
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, PYPAF2, E330007A02Rik, Nbs1, Pan1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223752
Homologene: 18199
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAG1, IGFBP-4ase, PAPP-A, 8430414N03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, LERN4, Lrrn6d
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320747
Homologene: 18563
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Spice1
Name: spindle and centriole associated protein 1
Synonyms: Ccdc52, D16Ertd480e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212514
Homologene: 16931
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Ctsh
Name: cathepsin H
Synonyms: Cat H
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13036
HGNC: HGNC:2535
Homologene: 36159
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: C030044P22Rik, ether a go-go like, Elk2, Melk2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Bin3
Name: bridging integrator 3
Synonyms: 1700015F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57784
VEGA: 14
HGNC: HGNC:1054
Homologene: 5472
Usp49
Name: ubiquitin specific peptidase 49
Synonyms: C330046L10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224836
Homologene: 10235
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Vmn1r224
Name: vomeronasal 1 receptor 224
Synonyms: Gm7673
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665525
Homologene: 85978
Apol9b
Name: apolipoprotein L 9b
Synonyms: 2310016F22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71898
VEGA: 15
Homologene: 77567
Plscr5
Name: phospholipid scramblase family, member 5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504689
Homologene: 28688
Lrrc10b
Name: leucine rich repeat containing 10B
Synonyms: Gm705, LOC278795, SerdinR
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 278795
VEGA: 19
Homologene: 19583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 62,745,406 bp
  • A to T, chromosome 2 at 65,098,033 bp
  • T to G, chromosome 2 at 80,350,664 bp
  • G to A, chromosome 2 at 104,762,830 bp
  • G to A, chromosome 2 at 129,115,762 bp
  • T to C, chromosome 2 at 157,040,764 bp
  • A to G, chromosome 2 at 160,761,463 bp
  • G to A, chromosome 3 at 94,403,206 bp
  • A to C, chromosome 3 at 108,461,256 bp
  • T to A, chromosome 4 at 3,184,975 bp
  • C to A, chromosome 4 at 46,522,118 bp
  • G to A, chromosome 4 at 65,204,654 bp
  • T to C, chromosome 4 at 134,087,587 bp
  • A to G, chromosome 4 at 147,583,775 bp
  • A to T, chromosome 5 at 14,677,893 bp
  • A to T, chromosome 5 at 105,608,609 bp
  • A to G, chromosome 5 at 122,881,744 bp
  • A to G, chromosome 7 at 5,337,761 bp
  • G to A, chromosome 7 at 104,012,031 bp
  • T to C, chromosome 8 at 35,807,560 bp
  • C to A, chromosome 9 at 15,090,152 bp
  • G to A, chromosome 9 at 21,403,136 bp
  • A to G, chromosome 9 at 90,062,743 bp
  • A to T, chromosome 9 at 92,205,556 bp
  • A to T, chromosome 9 at 109,449,101 bp
  • A to G, chromosome 10 at 70,559,557 bp
  • T to A, chromosome 10 at 82,290,368 bp
  • A to C, chromosome 11 at 17,947,505 bp
  • A to T, chromosome 11 at 69,746,913 bp
  • T to C, chromosome 14 at 20,560,968 bp
  • A to G, chromosome 14 at 70,137,176 bp
  • T to C, chromosome 15 at 8,118,042 bp
  • T to A, chromosome 15 at 77,735,304 bp
  • A to G, chromosome 15 at 86,134,919 bp
  • T to C, chromosome 15 at 99,227,038 bp
  • A to G, chromosome 16 at 44,370,697 bp
  • T to C, chromosome 17 at 7,758,485 bp
  • T to A, chromosome 17 at 20,419,766 bp
  • A to G, chromosome 17 at 31,846,296 bp
  • C to A, chromosome 17 at 47,680,822 bp
  • A to G, chromosome 17 at 65,824,729 bp
  • T to C, chromosome 18 at 14,807,355 bp
  • T to C, chromosome 19 at 10,456,978 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6303 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044410-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.