Strain Name:
C57BL/6J-MtgxR6282Btlr/Mmmh
Stock Number:
044452-MU
Citation ID:
RRID:MMRRC_044452-MU
Other Names:
R6282 (G1)
Major Collection:

Strain Information

Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Ldb2
Name: LIM domain binding 2
Synonyms: CLIM1, CLIM-1a, CLIM-1b, Ldb3, CLP-36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16826
HGNC: HGNC:6533
Homologene: 989
Cuedc1
Name: CUE domain containing 1
Synonyms: C330016O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103841
Homologene: 9933
Cdk18
Name: cyclin dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Axin1
Name: axin 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Rbm25
Name: RNA binding motif protein 25
Synonyms: A130095G20Rik, 2600011C06Rik, 2610015J01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Wdr20
Name: WD repeat domain 20
Synonyms: Wdr20a, 2310040A13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69641
Homologene: 32684
Map2k4
Name: mitogen-activated protein kinase kinase 4
Synonyms: Serk1, JNKK1, Sek1, MKK4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26398
HGNC: HGNC:6844
Homologene: 48159
Mettl3
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Synonyms: Spo8, M6A, 2310024F18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56335
Homologene: 10501
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Mrell, Rad50l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Sars1
Name: seryl-tRNA synthetase 1
Synonyms: Sars, Strs
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20226
Homologene: 4751
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Nrip3
Name: nuclear receptor interacting protein 3
Synonyms: A330103B05Rik, ICRFP703N2430Q5.2, D7H11orf14, ICRFP703B1614Q5.2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78593
HGNC: HGNC:1167
Homologene: 10764
Drap1
Name: DR1 associated protein 1
Synonyms: 2310074H19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66556
HGNC: HGNC:3019
Homologene: 4703
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217653
Homologene: 10147
Itgam
Name: integrin alpha M
Synonyms: CD11B (p170), Mac-1, F730045J24Rik, complement component receptor 3 alpha, Cd11b, CR3, CD11b/CD18, Mac-1 alpha, complement receptor type 3, Mac-1a, Ly-40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Cd180
Name: CD180 antigen
Synonyms: Ly78, RP105
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664837
Homologene: 69402
Usp35
Name: ubiquitin specific peptidase 35
Synonyms: LOC244144, LOC381901
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244144
Homologene: 35459
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Ntsr2
Name: neurotensin receptor 2
Synonyms: NT2R, NTRL
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18217
VEGA: 12
HGNC: HGNC:8040
Homologene: 7452
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Il10ra
Name: interleukin 10 receptor, alpha
Synonyms: CDw210, Il10r, mIL-10R
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16154
HGNC: HGNC:5964
Homologene: 1196
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 4930445I03Rik, 1700001O02Rik, 1700111D19Rik, 1700041C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Gm12790
Name: predicted gene 12790
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489970
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: OSBP3, 6720421I08Rik, ORP3, 1200014M06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: ARP1, 1110059C24Rik, ALP56, ASP21, CDA13, CEAP1, BAE2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Fam196b, Gm6041
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Or51h1
Name: olfactory receptor family 51 subfamily H member 1
Synonyms: MOR10-1, Olfr555, GA_x6K02T2PBJ9-5375442-5376389
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259107
Homologene: 51817
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Fbxo5
Name: F-box protein 5
Synonyms: Fbxo31, 2510044I10Rik, Emi1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67141
Homologene: 8135
Or4p7
Name: olfactory receptor family 4 subfamily P member 7
Synonyms: GA_x6K02T2Q125-49870417-49871388, MOR225-6P, Olfr1178
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258203
Homologene: 73979
Naprt
Name: nicotinate phosphoribosyltransferase
Synonyms: Naprt1, 9130210N20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223646
VEGA: 15
Homologene: 82285
Vash2
Name: vasohibin 2
Synonyms: B130052G07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226841
Homologene: 57005
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Or14j8
Name: olfactory receptor family 14 subfamily J member 8
Synonyms: Olfr761, GA_x6K02T2PSCP-2403971-2403000, MOR218-6P, Olfr1552-ps1, MOR218-12, MOR218-5P, MOR218-6P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258094
Homologene: 134080
Wfdc1
Name: WAP four-disulfide core domain 1
Synonyms: ps20, 2310058A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67866
Homologene: 10920
1700001O22Rik
Name: RIKEN cDNA 1700001O22 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73598
Homologene: 18859
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,503,601 bp
  • T to C, chromosome 1 at 132,120,020 bp
  • T to C, chromosome 1 at 190,960,225 bp
  • A to T, chromosome 2 at 30,800,769 bp
  • C to A, chromosome 2 at 88,391,533 bp
  • G to T, chromosome 3 at 108,428,274 bp
  • T to C, chromosome 4 at 88,630,054 bp
  • A to G, chromosome 4 at 101,967,516 bp
  • T to A, chromosome 4 at 119,324,017 bp
  • T to A, chromosome 4 at 147,583,348 bp
  • G to T, chromosome 4 at 149,659,743 bp
  • A to G, chromosome 5 at 26,260,413 bp
  • A to G, chromosome 5 at 44,532,665 bp
  • A to T, chromosome 6 at 50,348,083 bp
  • T to C, chromosome 7 at 97,325,948 bp
  • G to A, chromosome 7 at 102,659,647 bp
  • C to T, chromosome 7 at 109,763,479 bp
  • A to T, chromosome 7 at 128,084,942 bp
  • T to A, chromosome 8 at 88,670,460 bp
  • G to A, chromosome 8 at 119,679,407 bp
  • C to A, chromosome 9 at 45,260,405 bp
  • T to A, chromosome 10 at 5,801,216 bp
  • A to G, chromosome 10 at 79,544,742 bp
  • A to G, chromosome 11 at 34,402,819 bp
  • A to T, chromosome 11 at 53,669,770 bp
  • T to C, chromosome 11 at 65,707,016 bp
  • A to T, chromosome 11 at 80,557,512 bp
  • A to G, chromosome 11 at 88,183,402 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • A to T, chromosome 11 at 110,208,824 bp
  • A to T, chromosome 12 at 11,457,559 bp
  • A to G, chromosome 12 at 16,658,425 bp
  • A to G, chromosome 12 at 65,149,163 bp
  • T to C, chromosome 12 at 83,676,089 bp
  • T to A, chromosome 12 at 110,797,009 bp
  • G to A, chromosome 13 at 102,693,757 bp
  • A to T, chromosome 14 at 47,663,971 bp
  • A to T, chromosome 14 at 52,297,971 bp
  • A to T, chromosome 15 at 75,891,979 bp
  • A to T, chromosome 16 at 29,434,004 bp
  • A to T, chromosome 16 at 97,415,097 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • C to G, chromosome 17 at 26,143,037 bp
  • G to A, chromosome 17 at 37,952,424 bp
  • C to T, chromosome 18 at 37,301,646 bp
  • G to A, chromosome 19 at 5,424,436 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6282 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044452-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.