Strain Name:
C57BL/6J-MtgxR6287Btlr/Mmmh
Stock Number:
044457-MU
Citation ID:
RRID:MMRRC_044457-MU
Other Names:
R6287 (G1)
Major Collection:

Strain Information

Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Pigf
Name: phosphatidylinositol glycan anchor biosynthesis, class F
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18701
HGNC: HGNC:8962
Homologene: 31103
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: Pdzgef2, PDZ-GEF2, RA-GEF-2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Snx6
Name: sorting nexin 6
Synonyms: 2810425K19Rik, 2610032J07Rik, 2010006G21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Rrp15
Name: ribosomal RNA processing 15 homolog
Synonyms: 5430437H21Rik, 2810430M08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67223
Homologene: 32293
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: PipkIII, Pip5k3, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Flii
Name: flightless I actin binding protein
Synonyms: Fliih, 3632430F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, 2810054M15Rik, KRAB8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72723
Homologene: 51861
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Peg10
Name: paternally expressed 10
Synonyms: MyEF-3 like, Mar2, Mart2, MEF3L, HB-1, MyEF-3, Edr, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216874
Homologene: 9021
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 1110004P15Rik, DY6, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Or2y13
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: Olfr1383, GA_x6K02T2QP88-5912627-5911692, MOR256-56
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404337
Homologene: 105344
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239833
Homologene: 13198
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Or2a7
Name: olfactory receptor family 2 subfamily A member 7
Synonyms: MOR261-6, Olfr13, GA_x6K02T2P3E9-4384160-4383228
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18310
Homologene: 27232
Galk2
Name: galactokinase 2
Synonyms: Gk2, 2810017M24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69976
HGNC: HGNC:4119
Homologene: 13654
Chml
Name: choroideremia-like
Synonyms: E030003F13Rik, Rep2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12663
HGNC: HGNC:1941
Homologene: 31055
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625131
Homologene: 129606
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245174
Homologene: 136215
Ttl
Name: tubulin tyrosine ligase
Synonyms: 2700049H19Rik, 2410003M22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69737
Homologene: 32678
Omt2b
Name: oocyte maturation, beta
Synonyms: OM2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382088
Homologene: 136010
Tm4sf4
Name: transmembrane 4 superfamily member 4
Synonyms: il-TMP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229302
Homologene: 3393
Or6c69b
Name: olfactory receptor family 6 subfamily C member 69B
Synonyms: MOR113-4, GA_x6K02T2PULF-11470271-11469333, Olfr810
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258543
Homologene: 46347
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22033
Homologene: 27079
Or4a15
Name: olfactory receptor family 4 subfamily A member 15
Synonyms: MOR231-2, Olfr1234, GA_x6K02T2Q125-50805620-50804676
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258975
Homologene: 128156
Or10g3
Name: olfactory receptor family 10 subfamily G member 3
Synonyms: GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258424
HGNC: HGNC:8171
Homologene: 27165
Sap18
Name: Sin3-associated polypeptide 18
Synonyms: C530046K05Rik, Sap18a, D11Ertd539e, EMegR4, Sinbp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20220
Homologene: 4289
C330018D20Rik
Name: RIKEN cDNA C330018D20 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77422
Homologene: 35412
Defb6
Name: defensin beta 6
Synonyms: mBD-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 116746
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 65,253,532 bp
  • T to C, chromosome 1 at 175,687,003 bp
  • A to T, chromosome 1 at 186,749,176 bp
  • A to G, chromosome 1 at 191,999,872 bp
  • T to C, chromosome 2 at 53,014,848 bp
  • G to A, chromosome 2 at 89,363,019 bp
  • A to T, chromosome 2 at 125,870,348 bp
  • G to A, chromosome 2 at 129,089,121 bp
  • A to T, chromosome 2 at 150,238,341 bp
  • T to A, chromosome 3 at 57,425,691 bp
  • A to T, chromosome 5 at 76,918,214 bp
  • T to TCCC, chromosome 6 at 4,756,451 bp
  • A to G, chromosome 6 at 43,174,435 bp
  • G to A, chromosome 7 at 29,935,776 bp
  • T to A, chromosome 8 at 19,228,069 bp
  • T to C, chromosome 8 at 61,950,578 bp
  • A to G, chromosome 8 at 88,311,108 bp
  • T to C, chromosome 9 at 18,659,034 bp
  • T to C, chromosome 9 at 78,328,261 bp
  • T to C, chromosome 10 at 129,791,385 bp
  • C to T, chromosome 10 at 130,478,422 bp
  • A to G, chromosome 11 at 49,524,245 bp
  • T to G, chromosome 11 at 54,626,338 bp
  • A to T, chromosome 11 at 60,721,597 bp
  • G to C, chromosome 11 at 70,681,469 bp
  • T to C, chromosome 11 at 70,965,755 bp
  • G to T, chromosome 11 at 72,923,112 bp
  • G to T, chromosome 12 at 54,747,028 bp
  • A to T, chromosome 14 at 52,372,291 bp
  • A to G, chromosome 14 at 57,798,314 bp
  • T to C, chromosome 16 at 33,074,185 bp
  • A to T, chromosome 17 at 24,496,709 bp
  • T to A, chromosome 17 at 25,050,434 bp
  • G to A, chromosome 17 at 86,997,539 bp
  • A to C, chromosome 18 at 56,962,335 bp
  • T to A, chromosome 19 at 9,015,003 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6287 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044457-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.