Strain Name:
C57BL/6J-MtgxR6289Btlr/Mmmh
Stock Number:
044459-MU
Citation ID:
RRID:MMRRC_044459-MU
Other Names:
R6289 (G1)
Major Collection:

Strain Information

Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Rbm6
Name: RNA binding motif protein 6
Synonyms: g16, NY-LU-12, Def-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Trpc4ap
Name: transient receptor potential cation channel, subfamily C, member 4 associated protein
Synonyms: D2Ertd113e, Trp4-associated protein TAP1, Trrp4ap, 4833429F06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56407
Homologene: 9224
Tubgcp5
Name: tubulin, gamma complex component 5
Synonyms: GCP5, B130010C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233276
Homologene: 14172
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Click-II, Dcamkl2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70762
Homologene: 69431
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Rars1
Name: arginyl-tRNA synthetase 1
Synonyms: 2610011N19Rik, 2610037E21Rik, Rars
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Casp9
Name: caspase 9
Synonyms: Mch6, ICE-LAP6, Caspase-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12371
HGNC: HGNC:1511
Homologene: 31024
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 6820401H01Rik, 4930467M19Rik, 4632404N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Fgf22
Name: fibroblast growth factor 22
Synonyms: 2210414E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67112
VEGA: 10
HGNC: HGNC:3679
Homologene: 10770
Lifr
Name: LIF receptor alpha
Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Katnal2
Name: katanin p60 subunit A-like 2
Synonyms: 3110023G01Rik, 4933439B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71206
Homologene: 41725
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Ccl2
Name: C-C motif chemokine ligand 2
Synonyms: monocyte chemoattractant protein-1, Scya2, MCP1, HC11, SMC-CF, MCAF, monocyte chemotactic protein, Sigje, MCP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20296
Homologene: 2241
Fgf10
Name: fibroblast growth factor 10
Synonyms: Gsfaey17, AEY17, FGF-10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: A230065J02Rik, 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Ubtd2
Name: ubiquitin domain containing 2
Synonyms: 9630054F20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327900
Homologene: 15484
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76389
Homologene: 137366
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC, SREC-I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380713
Homologene: 2741
Keg1
Name: kidney expressed gene 1
Synonyms: 0610008P16Rik, GS4059
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 64697
Homologene: 69461
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Hpse2
Name: heparanase 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: AND-1, D630024B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218973
Homologene: 56019
Blk
Name: B lymphoid kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12143
VEGA: 14
HGNC: HGNC:1057
Homologene: 1297
Grip2
Name: glutamate receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243547
Homologene: 16327
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Arid3c
Name: AT-rich interaction domain 3C
Synonyms: OTTMUSG00000006683
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 550619
Homologene: 72499
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Septin8
Name: septin 8
Synonyms: Sepl, Sept8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20362
Homologene: 57205
H1f5
Name: H1.5 linker histone, cluster member
Synonyms: H1s-3, Hist1h1b, H1.5, H1f5, H1B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56702
HGNC: HGNC:4719
Homologene: 135981
Bex6
Name: brain expressed family member 6
Synonyms: B020003O03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328660
Or5b110-ps1
Name: olfactory receptor family 5 subfamily B member 110, pseudogene 1
Synonyms: Olfr1464-ps1, MOR202-27P, GA_x6K02T2RE5P-3614075-3613153, Gm8561
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667300
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 87,756,215 bp
  • T to C, chromosome 1 at 139,168,945 bp
  • T to C, chromosome 2 at 155,663,707 bp
  • A to T, chromosome 3 at 86,831,817 bp
  • C to T, chromosome 4 at 32,639,590 bp
  • G to A, chromosome 4 at 41,724,285 bp
  • T to A, chromosome 4 at 141,807,185 bp
  • T to G, chromosome 5 at 116,006,326 bp
  • A to G, chromosome 6 at 91,778,871 bp
  • A to G, chromosome 6 at 124,531,176 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to G, chromosome 7 at 55,795,923 bp
  • C to T, chromosome 8 at 45,396,929 bp
  • T to C, chromosome 9 at 107,777,948 bp
  • A to G, chromosome 10 at 79,755,207 bp
  • T to C, chromosome 11 at 5,628,837 bp
  • A to G, chromosome 11 at 32,516,177 bp
  • C to T, chromosome 11 at 35,826,067 bp
  • A to G, chromosome 11 at 42,155,019 bp
  • A to G, chromosome 11 at 53,534,478 bp
  • T to C, chromosome 11 at 60,778,598 bp
  • T to A, chromosome 11 at 75,525,416 bp
  • A to C, chromosome 11 at 82,036,969 bp
  • T to C, chromosome 11 at 87,859,659 bp
  • T to A, chromosome 12 at 25,056,616 bp
  • A to G, chromosome 12 at 81,560,706 bp
  • G to T, chromosome 13 at 21,780,439 bp
  • C to A, chromosome 13 at 118,715,492 bp
  • A to C, chromosome 14 at 47,258,496 bp
  • T to C, chromosome 14 at 63,375,892 bp
  • T to A, chromosome 14 at 119,041,602 bp
  • A to G, chromosome 15 at 7,166,910 bp
  • T to C, chromosome 15 at 98,649,884 bp
  • A to G, chromosome 16 at 32,186,712 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • A to G, chromosome 17 at 30,982,351 bp
  • A to G, chromosome 17 at 43,624,520 bp
  • A to G, chromosome 18 at 77,017,455 bp
  • T to G, chromosome 19 at 12,714,573 bp
  • T to C, chromosome 19 at 13,282,794 bp
  • T to A, chromosome 19 at 42,788,979 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6289 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044459-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.