Strain Name:
C57BL/6J-MtgxR6327Btlr/Mmmh
Stock Number:
044481-MU
Citation ID:
RRID:MMRRC_044481-MU
Other Names:
R6327 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: B430219L04Rik, mMTMH1, 4833411B01Rik, SBF2, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Nisch
Name: nischarin
Synonyms: edsn, 3202002H23Rik, 1200007D05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Oprm1
Name: opioid receptor, mu 1
Synonyms: MOR-1, MOP-R, MOP receptor, Oprm, muOR, mor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18390
HGNC: HGNC:8156
Homologene: 37368
Ckap2l
Name: cytoskeleton associated protein 2-like
Synonyms: Radmis, 2610318C08Rik, 2010016H04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70466
Homologene: 51866
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, TSP-1, Thbs-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Fosb
Name: FBJ osteosarcoma oncogene B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14282
HGNC: HGNC:3797
Homologene: 31403
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72201
Homologene: 6064
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: Efha2, 2900075B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78506
Homologene: 15058
Pamr1
Name: peptidase domain containing associated with muscle regeneration 1
Synonyms: E430002G05Rik, RAMP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 210622
Homologene: 9134
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Rcsd1
Name: RCSD domain containing 1
Synonyms: A430105K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226594
Homologene: 33475
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
C3ar1
Name: complement component 3a receptor 1
Synonyms: C3aR, anaphylatoxin C3a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Taar6
Name: trace amine-associated receptor 6
Synonyms: LOC215855
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215855
Homologene: 27874
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319800
Homologene: 77136
C2
Name: complement C2
Synonyms: classical-complement pathway C3/C5 convertase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12263
HGNC: HGNC:1248
Homologene: 45
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Or14c39
Name: olfactory receptor family 14 subfamily C member 39
Synonyms: GA_x6K02T2NHDJ-9425121-9424195, MOR220-2, Olfr292
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258613
Homologene: 115526
Serpinf1
Name: serine (or cysteine) peptidase inhibitor, clade F, member 1
Synonyms: Sdf3, Pedfl, EPC-1, pigment epithelium derived factor, Pedf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20317
HGNC: HGNC:8824
Homologene: 1965
Nfkbiz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Synonyms: Mail
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80859
Homologene: 12734
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Or2y1d
Name: olfactory receptor family 2 subfamily Y member 1D
Synonyms: GA_x6K02T2QP88-6004387-6003452, MOR256-1, Olfr1389
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259069
Homologene: 86690
Foxd4
Name: forkhead box D4
Synonyms: FREAC5, Fkh2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14237
VEGA: 19
Homologene: 83248
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Or13a26
Name: olfactory receptor family 13 subfamily A member 26
Synonyms: MOR253-3, Olfr541, GA_x6K02T2PBJ9-42850324-42851256
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258964
Homologene: 138322
Dld
Name: dihydrolipoamide dehydrogenase
Synonyms: branched chain alpha-keto acid dehydrogenase complex subunit E3, dihydrolipoyl dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13382
VEGA: 12
HGNC: HGNC:2898
Homologene: 84
Vmn1r65
Name: vomeronasal 1 receptor 65
Synonyms: V3R6, V1rd6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81013
Homologene: 110799
Mylk2
Name: myosin, light polypeptide kinase 2, skeletal muscle
Synonyms: 9830004H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228785
Homologene: 13223
Cmc2
Name: C-X9-C motif containing 2
Synonyms: 2310061C15Rik, 1110046L09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66531
Homologene: 41350
Timp3
Name: tissue inhibitor of metalloproteinase 3
Synonyms: Timp-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21859
Homologene: 36322
Uox
Name: urate oxidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22262
Homologene: 7584
Ehd1
Name: EH-domain containing 1
Synonyms: RME-1, Past1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Nudt17
Name: nudix hydrolase 17
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 17, 2410015C20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78373
Homologene: 45961
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,429,464 bp
  • T to A, chromosome 1 at 165,655,834 bp
  • A to T, chromosome 2 at 102,642,174 bp
  • G to T, chromosome 2 at 118,112,656 bp
  • A to G, chromosome 2 at 129,285,494 bp
  • A to G, chromosome 2 at 152,913,693 bp
  • T to A, chromosome 3 at 76,707,801 bp
  • T to C, chromosome 3 at 96,707,764 bp
  • G to A, chromosome 3 at 97,587,167 bp
  • T to A, chromosome 3 at 144,730,797 bp
  • C to T, chromosome 3 at 146,624,577 bp
  • A to G, chromosome 4 at 14,826,496 bp
  • C to T, chromosome 6 at 122,850,146 bp
  • T to C, chromosome 6 at 128,558,692 bp
  • A to T, chromosome 7 at 6,008,652 bp
  • G to T, chromosome 7 at 16,816,459 bp
  • T to C, chromosome 7 at 19,307,227 bp
  • T to C, chromosome 7 at 86,694,552 bp
  • T to C, chromosome 7 at 92,659,609 bp
  • C to T, chromosome 7 at 110,441,552 bp
  • T to C, chromosome 7 at 140,704,703 bp
  • A to G, chromosome 8 at 40,366,197 bp
  • G to T, chromosome 8 at 116,894,157 bp
  • A to C, chromosome 10 at 6,830,063 bp
  • A to G, chromosome 10 at 23,985,279 bp
  • C to T, chromosome 10 at 77,932,227 bp
  • T to C, chromosome 10 at 86,345,786 bp
  • A to C, chromosome 11 at 49,431,001 bp
  • A to G, chromosome 11 at 75,413,905 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • G to A, chromosome 12 at 31,332,191 bp
  • T to C, chromosome 13 at 21,982,332 bp
  • A to T, chromosome 13 at 89,704,832 bp
  • G to A, chromosome 13 at 102,761,382 bp
  • A to T, chromosome 14 at 31,171,487 bp
  • T to C, chromosome 15 at 47,881,387 bp
  • T to C, chromosome 16 at 55,821,962 bp
  • C to T, chromosome 17 at 34,043,317 bp
  • C to A, chromosome 17 at 34,864,103 bp
  • C to A, chromosome 17 at 74,662,779 bp
  • T to C, chromosome 18 at 20,539,870 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • T to C, chromosome 19 at 6,298,345 bp
  • T to G, chromosome 19 at 8,335,722 bp
  • T to A, chromosome 19 at 24,900,834 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6327 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044481-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.