Strain Name:
C57BL/6J-MtgxR6375Btlr/Mmmh
Stock Number:
044525-MU
Citation ID:
RRID:MMRRC_044525-MU
Other Names:
R6375 (G1)
Major Collection:

Strain Information

Mon1b
Name: MON1 homolog B, secretory traffciking associated
Synonyms: 5033413H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270096
Homologene: 69174
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 9530077A04Rik, Mll5, 1810033J14Rik, D230038D11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Pias2
Name: protein inhibitor of activated STAT 2
Synonyms: ARIP3, 6330408K17Rik, Dib, PIASxalpha, PIASxbeta, Miz1, PIASxb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17344
VEGA: 18
Homologene: 20979
Lynx1
Name: Ly6/neurotoxin 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23936
Homologene: 8026
Snx3
Name: sorting nexin 3
Synonyms: SDP3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54198
Homologene: 36144
Tmem39a
Name: transmembrane protein 39a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67846
Homologene: 9985
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Stk39
Name: serine/threonine kinase 39
Synonyms: SPAK, DCHT, RF005, Rnl5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53416
Homologene: 22739
Nbn
Name: nibrin
Synonyms: Nbs1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27354
HGNC: HGNC:7652
Homologene: 1858
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Fgfr-2, Fgfr2b, Fgfr-7, KGFRTr, Bek, svs, Fgfr7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Aplp2
Name: amyloid beta precursor-like protein 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11804
VEGA: 9
HGNC: HGNC:598
Homologene: 20396
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: mRib72-1, myoclonin1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Zfp637
Name: zinc finger protein 637
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232337
Homologene: 5069
Ccser1
Name: coiled-coil serine rich 1
Synonyms: Fam190a, C130092O11Rik, 6230405M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1304Clo, b2b2025.1Clo, b2b1735Clo, 4921507O14Rik, prh, D3Ertd789e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74424
Homologene: 11713
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: 2900073F20Rik, Tsh2, Mtsh2, Sdccag33l, Zfp218, teashirt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228911
Homologene: 35258
Fmo9
Name: flavin containing monooxygenase 9
Synonyms: 4831428F09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240894
Homologene: 134192
Or10al5
Name: olfactory receptor family 10 subfamily AL member 5
Synonyms: GA_x6K02T2PSCP-2211113-2212078, Olfr121, MOR263-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258622
Homologene: 17195
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: alpha1E, Cchra1, Cav2.3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: KShIIIA, Kv3.2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 636697
Homologene: 41799
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Or14c39
Name: olfactory receptor family 14 subfamily C member 39
Synonyms: GA_x6K02T2NHDJ-9425121-9424195, MOR220-2, Olfr292
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258613
Homologene: 115526
Or2ag2
Name: olfactory receptor family 2 subfamily AG member 2
Synonyms: Olfr706, GA_x6K02T2PBJ9-9271198-9270248, MOR283-11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258350
Homologene: 133646
Kcnk9
Name: potassium channel, subfamily K, member 9
Synonyms: Task3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223604
VEGA: 15
HGNC: HGNC:6283
Homologene: 56758
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234258
Homologene: 10094
Hoxb4
Name: homeobox B4
Synonyms: Hox-2.6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15412
HGNC: HGNC:5115
Homologene: 32095
Il1r1
Name: interleukin 1 receptor, type I
Synonyms: Il1r-1, IL-1 receptor alpha chain, CD121a, IL-iR, IL-1R1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16177
HGNC: HGNC:5993
Homologene: 677
Thap4
Name: THAP domain containing 4
Synonyms: 2010320B01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67026
Homologene: 12075
Actbl2
Name: actin, beta-like 2
Synonyms: 4732495G21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238880
Homologene: 134276
Or51g2
Name: olfactory receptor family 51 subfamily G member 2
Synonyms: GA_x6K02T2PBJ9-5685322-5684384, Olfr577, MOR7-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259113
Homologene: 64962
Pcdhgb6
Name: protocadherin gamma subfamily B, 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93703
HGNC: HGNC:8713
Homologene: 49573
Scgb1b12
Name: secretoglobin, family 1B, member 12
Synonyms: Abpa12, Gm9140
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668381
Homologene: 114479
Alyreffm5
Name: Aly/REF export factor family member 5
Synonyms: Gm4302
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100043227
VEGA: 10
Homologene: 130068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,972,940 bp
  • T to A, chromosome 1 at 40,294,890 bp
  • C to A, chromosome 1 at 93,725,156 bp
  • A to C, chromosome 1 at 154,479,305 bp
  • A to G, chromosome 1 at 166,664,595 bp
  • T to A, chromosome 2 at 68,392,238 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • A to G, chromosome 2 at 169,886,019 bp
  • T to A, chromosome 3 at 33,814,367 bp
  • T to A, chromosome 4 at 3,745,527 bp
  • T to A, chromosome 4 at 15,979,327 bp
  • C to T, chromosome 4 at 74,330,715 bp
  • T to C, chromosome 5 at 23,499,519 bp
  • T to C, chromosome 5 at 108,174,954 bp
  • A to C, chromosome 6 at 42,626,178 bp
  • T to A, chromosome 6 at 61,311,168 bp
  • C to T, chromosome 6 at 117,845,324 bp
  • T to C, chromosome 7 at 5,545,018 bp
  • T to A, chromosome 7 at 32,334,459 bp
  • C to T, chromosome 7 at 86,695,059 bp
  • T to C, chromosome 7 at 102,973,753 bp
  • C to A, chromosome 7 at 106,886,014 bp
  • T to A, chromosome 7 at 118,656,814 bp
  • C to A, chromosome 7 at 130,167,745 bp
  • T to C, chromosome 8 at 53,587,276 bp
  • T to A, chromosome 8 at 113,638,077 bp
  • T to C, chromosome 9 at 31,157,788 bp
  • A to T, chromosome 9 at 119,543,356 bp
  • T to A, chromosome 10 at 42,534,731 bp
  • A to G, chromosome 10 at 100,341,396 bp
  • C to T, chromosome 10 at 112,463,189 bp
  • A to G, chromosome 11 at 96,320,327 bp
  • A to T, chromosome 11 at 96,820,051 bp
  • G to A, chromosome 11 at 103,501,089 bp
  • A to G, chromosome 11 at 116,458,228 bp
  • T to C, chromosome 12 at 98,798,868 bp
  • A to G, chromosome 13 at 111,255,944 bp
  • C to T, chromosome 15 at 72,546,243 bp
  • T to C, chromosome 15 at 74,751,319 bp
  • G to A, chromosome 15 at 76,177,640 bp
  • A to G, chromosome 16 at 32,736,243 bp
  • A to G, chromosome 16 at 38,585,237 bp
  • T to A, chromosome 17 at 24,387,562 bp
  • T to A, chromosome 17 at 37,752,099 bp
  • A to T, chromosome 18 at 37,518,304 bp
  • A to G, chromosome 18 at 37,742,625 bp
  • C to T, chromosome 18 at 77,152,670 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6375 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044525-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.