Strain Name:
C57BL/6J-MtgxR6384Btlr/Mmmh
Stock Number:
044533-MU
Citation ID:
RRID:MMRRC_044533-MU
Other Names:
R6384 (G1)
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: D10Bwg0738e, Kif5, Khc, Kns
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Cdr2
Name: cerebellar degeneration-related 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12585
HGNC: HGNC:1799
Homologene: 7262
Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Synonyms: G alpha q, 6230401I02Rik, 1110005L02Rik, Gq, Dsk1, Galphaq, Dsk10, GqI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14682
HGNC: HGNC:4390
Homologene: 1566
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: KAT9, 2610507P14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Yars1
Name: tyrosyl-tRNA synthetase 1
Synonyms: Yars
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107271
Homologene: 2730
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24088
Homologene: 20695
Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
Synonyms: Eps15R, Eps15-rs, 9830147J04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13859
Homologene: 31881
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
F11r
Name: F11 receptor
Synonyms: Ly106, JAM-A, JAM-1, ESTM33, BV11 antigen, Jcam1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16456
Homologene: 14255
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72946
Homologene: 10795
Foxp2
Name: forkhead box P2
Synonyms: D0Kist7, 2810043D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114142
Homologene: 134404
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71985
Homologene: 49825
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 338348
Homologene: 17011
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, Slc21a13, 4930422F19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase, Spi2A, alpha-1 antiproteinase,, Spi2-1, 2A2, Spi2/eb.1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: C motif-1/lymphotactin receptor, Ccxcr1, GPR5, XCR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Ednra
Name: endothelin receptor type A
Synonyms: ETa, Mhdaaea1, ET-AR, AEA001, Gpcr10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13617
HGNC: HGNC:3179
Homologene: 1478
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214804
Homologene: 19035
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
Synpo2
Name: synaptopodin 2
Synonyms: 1110069I04Rik, 9530006G20Rik, Myo, myopodin, 2310068J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Or8g27
Name: olfactory receptor family 8 subfamily G member 27
Synonyms: MOR171-19, Olfr944, GA_x6K02T2PVTD-32914568-32915503
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258500
VEGA: 9
Homologene: 110610
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: Rgsl2, 4930415K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Cdca3
Name: cell division cycle associated 3
Synonyms: 2410005A12Rik, TOME-1, Grcc8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14793
Homologene: 8403
Ccnj
Name: cyclin J
Synonyms: D430039C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240665
Homologene: 10413
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56233
Homologene: 9124
Pdcl2
Name: phosducin-like 2
Synonyms: Mgcphlp, 1700016K07Rik, 1700010B22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79455
Homologene: 74832
Or8k30
Name: olfactory receptor family 8 subfamily K member 30
Synonyms: MOR189-2, Olfr1076, GA_x6K02T2Q125-47993761-47994702
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258401
Homologene: 17233
Adamts5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
Amz2
Name: archaelysin family metallopeptidase 2
Synonyms: ESTM12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13929
Pdcd5
Name: programmed cell death 5
Synonyms: 2200003D22Rik, Tfar19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56330
HGNC: HGNC:8764
Homologene: 10506
Tubb5
Name: tubulin, beta 5 class I
Synonyms: B130022C14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22154
Homologene: 69099
Hmga2
Name: high mobility group AT-hook 2
Synonyms: Hmgic, HMGI-C, 9430083A20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15364
HGNC: HGNC:5009
Homologene: 2602
Rbfa
Name: ribosome binding factor A
Synonyms: 1110032A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68731
VEGA: 18
Homologene: 11725
Slc6a16
Name: solute carrier family 6, member 16
Synonyms: LOC381884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381884
Homologene: 49366
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 153,827,545 bp
  • A to G, chromosome 1 at 171,460,940 bp
  • T to C, chromosome 2 at 21,826,288 bp
  • T to C, chromosome 2 at 29,173,558 bp
  • C to T, chromosome 2 at 32,767,549 bp
  • A to G, chromosome 2 at 86,509,037 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • T to C, chromosome 2 at 153,391,824 bp
  • A to G, chromosome 3 at 83,836,994 bp
  • G to A, chromosome 3 at 123,113,049 bp
  • T to A, chromosome 3 at 145,998,813 bp
  • T to A, chromosome 4 at 32,670,607 bp
  • T to G, chromosome 4 at 129,196,978 bp
  • T to C, chromosome 4 at 154,015,860 bp
  • C to T, chromosome 5 at 76,331,008 bp
  • T to A, chromosome 5 at 90,472,640 bp
  • T to A, chromosome 5 at 121,652,003 bp
  • C to T, chromosome 6 at 15,437,948 bp
  • C to T, chromosome 6 at 124,832,419 bp
  • C to T, chromosome 6 at 142,109,379 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • G to T, chromosome 7 at 35,646,909 bp
  • A to G, chromosome 7 at 45,257,593 bp
  • G to A, chromosome 7 at 120,982,128 bp
  • T to A, chromosome 8 at 43,650,799 bp
  • A to T, chromosome 8 at 72,368,710 bp
  • T to C, chromosome 8 at 77,689,094 bp
  • T to C, chromosome 9 at 39,217,978 bp
  • T to A, chromosome 9 at 123,855,782 bp
  • T to C, chromosome 10 at 93,211,965 bp
  • G to A, chromosome 10 at 120,370,707 bp
  • T to C, chromosome 10 at 127,242,775 bp
  • A to G, chromosome 11 at 109,429,034 bp
  • A to C, chromosome 12 at 83,803,974 bp
  • A to G, chromosome 12 at 104,240,396 bp
  • A to T, chromosome 13 at 111,750,530 bp
  • T to C, chromosome 14 at 65,560,211 bp
  • G to A, chromosome 15 at 97,811,506 bp
  • A to G, chromosome 15 at 102,224,451 bp
  • A to G, chromosome 16 at 23,974,865 bp
  • C to T, chromosome 16 at 85,862,828 bp
  • C to T, chromosome 16 at 87,719,857 bp
  • T to C, chromosome 17 at 22,605,155 bp
  • T to C, chromosome 17 at 35,838,046 bp
  • T to C, chromosome 18 at 80,192,781 bp
  • A to G, chromosome 19 at 16,316,013 bp
  • A to T, chromosome 19 at 39,392,293 bp
  • T to C, chromosome 19 at 40,846,007 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6384 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044533-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.