Strain Name:
C57BL/6J-MtgxR6386Btlr/Mmmh
Stock Number:
044535-MU
Citation ID:
RRID:MMRRC_044535-MU
Other Names:
R6386 (G1)
Major Collection:

Strain Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74123
Homologene: 12536
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Cop1, Rfwd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26374
Homologene: 115565
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Mtch2
Name: mitochondrial carrier 2
Synonyms: 2310034D24Rik, HSPC032, 4930539J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56428
Homologene: 8645
Rps24
Name: ribosomal protein S24
Synonyms: MRP S24
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20088
VEGA: 14
Homologene: 68148
Wbp11
Name: WW domain binding protein 11
Synonyms: SIPP1, Npwbp, 2510026P17Rik, D6Wsu113e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 60321
Homologene: 134037
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Wasf3
Name: WASP family, member 3
Synonyms: Wave3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245880
Homologene: 68527
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103268
Homologene: 12254
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Tpgs2
Name: tubulin polyglutamylase complex subunit 2
Synonyms: 5730437P09Rik, 5730494M16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66648
Homologene: 9161
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 96957
Homologene: 11801
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228592
Homologene: 136180
Gpatch1
Name: G patch domain containing 1
Synonyms: Gpatc1, 1300003A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67471
Homologene: 41217
Atf6b
Name: activating transcription factor 6 beta
Synonyms: Creb-rp, ATF6beta, Crebl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Cyp4a29
Name: cytochrome P450, family 4, subfamily a, polypeptide 29
Synonyms: Cyp4a29-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230639
Npffr2
Name: neuropeptide FF receptor 2
Synonyms: NPFF2, Gpr74
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 104443
HGNC: HGNC:4525
Homologene: 56982
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Freud-1, Tape
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212139
Homologene: 23040
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, Psg24, EG384557
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: mPgt, Slc21a2, 2310021C19Rik, Pgt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24059
Homologene: 38077
Rnf148
Name: ring finger protein 148
Synonyms: 4933432M07Rik, Greul3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700024K14Rik, 1700074B05Rik, 4833417L20Rik, 5830409B12Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Or4d10b
Name: olfactory receptor family 4 subfamily D member 10B
Synonyms: GA_x6K02T2RE5P-2418550-2417609, Olfr1424, MOR239-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258676
Homologene: 82294
Gje1
Name: gap junction protein, epsilon 1
Synonyms: Gjf1, AEY12, D230044M03Rik, Gsfaey12, connexin 23, Cx23
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76743
Homologene: 87405
Prl3d2
Name: prolactin family 3, subfamily d, member 1
Synonyms: Plib, PL-Ib
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215028
Homologene: 137215
Syndig1
Name: synapse differentiation inducing 1
Synonyms: Tmem90b, SynDIG1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433485
Homologene: 11771
Mvb12b
Name: multivesicular body subunit 12B
Synonyms: Fam125b, 2610528K11Rik, 2610200O14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72543
Homologene: 25444
Rfc5
Name: replication factor C (activator 1) 5
Synonyms: Recc5, 2610020K06Rik, 36kDa, 36.5kDa, 2610209F07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72151
HGNC: HGNC:9973
Homologene: 6730
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: GA_x6K02T2PBJ9-10489044-10488091, Olfr485, MOR204-40_p, MOR204-30P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Ak6
Name: adenylate kinase 6
Synonyms: 4921516M08Rik, 2810046E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102216272
Homologene: 5540
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,551,020 bp
  • T to A, chromosome 1 at 87,699,675 bp
  • T to C, chromosome 1 at 159,289,031 bp
  • A to T, chromosome 2 at 33,827,742 bp
  • A to G, chromosome 2 at 90,849,395 bp
  • C to T, chromosome 2 at 120,999,114 bp
  • G to A, chromosome 2 at 129,472,818 bp
  • C to A, chromosome 2 at 149,899,576 bp
  • T to C, chromosome 2 at 172,377,896 bp
  • A to T, chromosome 3 at 76,322,066 bp
  • T to G, chromosome 4 at 115,247,075 bp
  • A to T, chromosome 5 at 62,604,522 bp
  • T to C, chromosome 5 at 89,582,697 bp
  • T to C, chromosome 5 at 117,385,398 bp
  • A to T, chromosome 5 at 146,453,417 bp
  • A to G, chromosome 6 at 23,654,484 bp
  • T to C, chromosome 6 at 136,820,525 bp
  • A to G, chromosome 7 at 17,158,219 bp
  • T to C, chromosome 7 at 35,291,840 bp
  • A to T, chromosome 7 at 86,922,337 bp
  • A to T, chromosome 7 at 108,159,202 bp
  • A to G, chromosome 8 at 84,138,537 bp
  • G to A, chromosome 9 at 103,076,988 bp
  • A to G, chromosome 10 at 14,716,621 bp
  • A to T, chromosome 10 at 41,743,132 bp
  • T to C, chromosome 12 at 103,593,105 bp
  • T to C, chromosome 12 at 109,025,065 bp
  • A to G, chromosome 13 at 27,127,303 bp
  • T to C, chromosome 13 at 67,474,843 bp
  • TGACGA to TGA, chromosome 13 at 100,655,803 bp
  • G to A, chromosome 14 at 24,492,048 bp
  • T to C, chromosome 16 at 15,968,560 bp
  • T to C, chromosome 17 at 34,651,851 bp
  • T to C, chromosome 17 at 47,878,462 bp
  • C to A, chromosome 17 at 71,834,194 bp
  • A to T, chromosome 18 at 25,139,024 bp
  • A to T, chromosome 19 at 12,059,556 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6386 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044535-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.