Strain Name:
C57BL/6J-MtgxR6409Btlr/Mmmh
Stock Number:
044554-MU
Citation ID:
RRID:MMRRC_044554-MU
Other Names:
R6409 (G1)
Major Collection:

Strain Information

Sfrp1
Name: secreted frizzled-related protein 1
Synonyms: sFRP-1, 2210415K03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20377
Homologene: 2266
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Zfp106
Name: zinc finger protein 106
Synonyms: Cd-1, H3a, sirm, Sh3bp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20402
Homologene: 40787
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, GRAM domain, HBLP1, AD3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Sertm1
Name: serine rich and transmembrane domain containing 1
Synonyms: 6030405A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329641
Homologene: 45594
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: PGR23, Gpr113, LOC381628
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Ms4a4b
Name: membrane-spanning 4-domains, subfamily A, member 4B
Synonyms: Ly116, Chandra
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60361
Homologene: 113790
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Pmm1
Name: phosphomannomutase 1
Synonyms: Secp53 (yeast) homolog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29858
HGNC: HGNC:9114
Homologene: 90898
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: D730019B10Rik, TFL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214593
Homologene: 9689
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Rfc4
Name: replication factor C (activator 1) 4
Synonyms: RFC37, A1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106344
HGNC: HGNC:9972
Homologene: 6288
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: A730013O20Rik, C130038G02Rik, 5730592G18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77521
Homologene: 78141
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Or1x2
Name: olfactory receptor family 1 subfamily X member 2
Synonyms: GA_x6K02T2QP88-4411197-4410256, Olfr54, MOR126-1, F3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18354
Homologene: 115479
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: Olfr1098, MOR206-1, GA_x6K02T2Q125-48410458-48409511
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258842
Homologene: 37005
Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
Synonyms: mPMAT, ENT4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243328
Homologene: 71345
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, FMF, pyrin, TRIM20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381694
Homologene: 14978
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: Cea-3, Cea3, mmCGM6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26438
HGNC: HGNC:9524
Homologene: 110989
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319757
Homologene: 4115
Rgs18
Name: regulator of G-protein signaling 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64214
Homologene: 11281
Or4d10
Name: olfactory receptor family 4 subfamily D member 10
Synonyms: MOR239-7, GA_x6K02T2RE5P-2433425-2432490, Olfr1425
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258155
Homologene: 17398
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,372,588 bp
  • T to A, chromosome 1 at 144,775,193 bp
  • A to G, chromosome 2 at 72,178,237 bp
  • A to T, chromosome 2 at 86,923,171 bp
  • A to T, chromosome 2 at 120,532,104 bp
  • G to C, chromosome 2 at 122,284,667 bp
  • A to G, chromosome 2 at 152,999,341 bp
  • T to C, chromosome 3 at 54,899,367 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • C to T, chromosome 4 at 101,940,677 bp
  • A to G, chromosome 5 at 30,197,314 bp
  • A to G, chromosome 5 at 109,216,230 bp
  • A to G, chromosome 5 at 142,712,071 bp
  • T to C, chromosome 5 at 148,077,615 bp
  • C to T, chromosome 5 at 149,735,451 bp
  • T to C, chromosome 6 at 29,736,114 bp
  • T to A, chromosome 6 at 119,282,228 bp
  • T to C, chromosome 7 at 18,353,521 bp
  • A to T, chromosome 7 at 101,828,961 bp
  • G to A, chromosome 7 at 131,262,071 bp
  • T to C, chromosome 8 at 23,417,378 bp
  • A to G, chromosome 10 at 7,867,318 bp
  • T to C, chromosome 10 at 50,845,580 bp
  • T to C, chromosome 10 at 92,967,492 bp
  • A to G, chromosome 11 at 51,027,188 bp
  • T to C, chromosome 11 at 70,944,972 bp
  • G to T, chromosome 11 at 120,011,732 bp
  • T to C, chromosome 15 at 81,960,807 bp
  • C to A, chromosome 16 at 3,710,793 bp
  • T to A, chromosome 16 at 21,478,439 bp
  • T to C, chromosome 16 at 23,114,073 bp
  • T to A, chromosome 16 at 36,761,870 bp
  • A to G, chromosome 17 at 8,949,438 bp
  • G to A, chromosome 19 at 9,009,574 bp
  • T to C, chromosome 19 at 11,461,360 bp
  • C to T, chromosome 19 at 12,074,747 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6409 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044554-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.