Strain Name:
C57BL/6J-MtgxR6439Btlr/Mmmh
Stock Number:
044577-MU
Citation ID:
RRID:MMRRC_044577-MU
Other Names:
R6439 (G1)
Major Collection:

Strain Information

Fam117b
Name: family with sequence similarity 117, member B
Synonyms: 2810425F24Rik, Als2cr13, 6330416D14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72750
Homologene: 18307
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170935
Homologene: 15781
Igfbp5
Name: insulin-like growth factor binding protein 5
Synonyms: IGFBP-5P, IGFBP-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16011
HGNC: HGNC:5474
Homologene: 56489
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, rh, bldy, rh-bmh, ba
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810013C04Rik, 2810040A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Ms4a4c
Name: membrane-spanning 4-domains, subfamily A, member 4C
Synonyms: 5830413L19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 64380
Homologene: 113790
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: D8Ertd281e, NFAT4, NFATx
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Hbp1
Name: high mobility group box transcription factor 1
Synonyms: C86454, 1700058O05Rik, C330012F01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73389
Homologene: 8171
Brd3
Name: bromodomain containing 3
Synonyms: ORFX, RINGL3, Fsrg2, 2410084F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234875
Homologene: 11569
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, Ugcgl1, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56739
Homologene: 3768
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Or5ak24
Name: olfactory receptor family 5 subfamily AK member 24
Synonyms: Olfr994, MOR203-4, GA_x6K02T2Q125-46907515-46906571
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258425
Homologene: 17245
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226250
Homologene: 13057
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Ttc14
Name: tetratricopeptide repeat domain 14
Synonyms: cI-44, 4933402I15Rik, 2700016E08Rik, 4930434D01Rik, 4931403I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67120
Homologene: 12085
A530064D06Rik
Name: RIKEN cDNA A530064D06 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328830
VEGA: 17
Homologene: 136361
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl-II, CD110, c-mpl-I, hlb219, TPO-R, thrombopoietin receptor, c-mpl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
9130401M01Rik
Name: RIKEN cDNA 9130401M01 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75758
Homologene: 12622
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54367
Homologene: 10297
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, Psg24, EG384557
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
Vmn1r183
Name: vomeronasal 1 receptor 183
Synonyms: V1rd15, LOC209824
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209824
Homologene: 104166
Phf1
Name: PHD finger protein 1
Synonyms: PHF2, D17Ertd455e, Tctex3, Tctex-3, mPcl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
Or4f47
Name: olfactory receptor family 4 subfamily F member 47
Synonyms: GA_x6K02T2Q125-73188162-73189112, MOR245-4, Olfr1317
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258440
Homologene: 71983
Or7a42
Name: olfactory receptor family 7 subfamily A member 42
Synonyms: GA_x6K02T2QGN0-2857086-2856154, Olfr8, MOR139-5P
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18372
Homologene: 136441
Abhd6
Name: abhydrolase domain containing 6
Synonyms: 0610041D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66082
VEGA: 14
Homologene: 23246
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,174,951 bp
  • A to G, chromosome 1 at 59,981,572 bp
  • A to C, chromosome 1 at 72,863,141 bp
  • A to G, chromosome 1 at 93,183,404 bp
  • A to G, chromosome 2 at 27,463,926 bp
  • T to C, chromosome 2 at 85,430,724 bp
  • T to C, chromosome 2 at 112,142,164 bp
  • T to C, chromosome 3 at 33,808,819 bp
  • T to C, chromosome 4 at 118,448,553 bp
  • C to A, chromosome 4 at 118,588,975 bp
  • T to G, chromosome 5 at 105,888,718 bp
  • A to T, chromosome 5 at 143,373,502 bp
  • A to T, chromosome 7 at 11,679,137 bp
  • G to A, chromosome 7 at 17,158,328 bp
  • A to G, chromosome 7 at 24,055,279 bp
  • A to G, chromosome 7 at 73,480,406 bp
  • C to T, chromosome 8 at 40,754,590 bp
  • T to C, chromosome 8 at 43,625,951 bp
  • T to A, chromosome 8 at 106,083,870 bp
  • T to C, chromosome 8 at 124,673,482 bp
  • T to A, chromosome 10 at 78,955,984 bp
  • A to G, chromosome 12 at 31,937,721 bp
  • T to C, chromosome 12 at 40,068,946 bp
  • T to C, chromosome 14 at 8,055,589 bp
  • A to G, chromosome 14 at 55,618,619 bp
  • A to G, chromosome 14 at 70,561,836 bp
  • A to G, chromosome 14 at 103,155,475 bp
  • T to C, chromosome 15 at 58,032,048 bp
  • T to C, chromosome 15 at 81,712,135 bp
  • G to T, chromosome 17 at 26,936,612 bp
  • A to G, chromosome 17 at 48,166,485 bp
  • G to A, chromosome 17 at 79,627,542 bp
  • C to T, chromosome 18 at 37,969,434 bp
  • T to C, chromosome 19 at 11,421,312 bp
  • C to T, chromosome 19 at 29,309,622 bp
  • T to C, chromosome 19 at 56,928,386 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6439 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044577-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.