Strain Name:
C57BL/6J-MtgxR6485Btlr/Mmmh
Stock Number:
044617-MU
Citation ID:
RRID:MMRRC_044617-MU
Other Names:
R6485 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: bt, ADAMTS-20
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Sfrs16, Srsf16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: 1200014D22Rik, LKB1IP, LIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur4, spkw1, Gluralpha4, Glur-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Gcfc2
Name: GC-rich sequence DNA binding factor 2
Synonyms: AW146020
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330361
HGNC: HGNC:1317
Homologene: 2411
Pgd
Name: phosphogluconate dehydrogenase
Synonyms: 0610042A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110208
HGNC: HGNC:8891
Homologene: 68268
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Arhgap33
Name: Rho GTPase activating protein 33
Synonyms: Tcgap, Snx26, NOMA-GAP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233071
Homologene: 76448
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: coffeecrisp, 1810049K24Rik, Lgl1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78892
Homologene: 41792
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Lonrf1
Name: LON peptidase N-terminal domain and ring finger 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244421
Homologene: 34980
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Zic5
Name: zinc finger protein of the cerebellum 5
Synonyms: 1700049L20Rik, Opr, odd-paired related
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65100
Homologene: 11301
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Large2
Name: LARGE xylosyl- and glucuronyltransferase 2
Synonyms: Gyltl1b, 5730485C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228366
Homologene: 27362
Exph5
Name: exophilin 5
Synonyms: AC079869.22gm5, slac2-b, B130009M24Rik, Slac2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28088
Homologene: 36344
Slc25a30
Name: solute carrier family 25, member 30
Synonyms: 4933433D23Rik, KMCP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67554
VEGA: 14
Homologene: 57046
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, 2010016F01Rik, harmonin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72088
Homologene: 77476
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, 2900064B05Rik, BF-1, Bf1, Hfhbf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Bcl2a1c
Name: B cell leukemia/lymphoma 2 related protein A1c
Synonyms: A1-c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12046
HGNC: HGNC:991
Gba2
Name: glucosidase beta 2
Synonyms: bile acid
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230101
Homologene: 10859
Ripply1
Name: ripply transcriptional repressor 1
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 622473
Homologene: 134609
Mrgprb5
Name: MAS-related GPR, member B5
Synonyms: MrgB5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404239
Homologene: 115575
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Fads6
Name: fatty acid desaturase domain family, member 6
Synonyms: BC050213, OTTMUSG00000021749
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 328035
Homologene: 18646
Acot5
Name: acyl-CoA thioesterase 5
Synonyms: PTE-Ic
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217698
Homologene: 77351
Or2b2
Name: olfactory receptor family 2 subfamily B member 2
Synonyms: MOR256-60, MOR256-35, Olfr1359, GA_x6K02T2QHY8-11534186-11533245
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258067
Homologene: 11056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,294,529 bp
  • T to C, chromosome 1 at 75,529,968 bp
  • T to C, chromosome 2 at 92,366,028 bp
  • A to C, chromosome 4 at 43,574,118 bp
  • A to T, chromosome 4 at 149,156,419 bp
  • A to G, chromosome 5 at 16,354,657 bp
  • A to G, chromosome 5 at 41,817,116 bp
  • A to T, chromosome 5 at 75,175,074 bp
  • T to C, chromosome 6 at 81,939,547 bp
  • C to A, chromosome 7 at 19,586,369 bp
  • T to C, chromosome 7 at 30,524,004 bp
  • A to T, chromosome 7 at 46,209,110 bp
  • T to C, chromosome 7 at 48,168,777 bp
  • C to A, chromosome 7 at 120,427,167 bp
  • T to A, chromosome 7 at 141,746,736 bp
  • A to G, chromosome 8 at 36,229,134 bp
  • A to G, chromosome 8 at 120,029,309 bp
  • T to A, chromosome 9 at 4,464,249 bp
  • G to A, chromosome 9 at 53,376,691 bp
  • A to G, chromosome 9 at 106,076,870 bp
  • T to C, chromosome 9 at 114,330,210 bp
  • G to T, chromosome 10 at 76,389,330 bp
  • T to C, chromosome 10 at 85,957,644 bp
  • T to C, chromosome 11 at 76,808,707 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • T to C, chromosome 11 at 104,505,648 bp
  • A to G, chromosome 11 at 115,285,438 bp
  • A to T, chromosome 12 at 49,385,080 bp
  • A to T, chromosome 12 at 84,075,484 bp
  • A to T, chromosome 12 at 98,698,872 bp
  • A to G, chromosome 13 at 21,703,430 bp
  • G to T, chromosome 13 at 103,868,113 bp
  • G to T, chromosome 14 at 75,775,007 bp
  • T to A, chromosome 14 at 122,459,640 bp
  • T to C, chromosome 15 at 79,307,372 bp
  • T to C, chromosome 15 at 94,343,971 bp
  • T to C, chromosome 18 at 21,129,837 bp
  • T to C, chromosome 18 at 22,770,793 bp
  • T to C, chromosome 19 at 16,680,050 bp
  • TTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCT to TTCCTCCTCCTCCTCCTCCTCCTCCTCCT, chromosome X at 139,779,850 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6485 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044617-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.