Strain Name:
C57BL/6J-MtgxR6492Btlr/Mmmh
Stock Number:
044624-MU
Citation ID:
RRID:MMRRC_044624-MU
Other Names:
R6492 (G1)
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: TRP1, TRP-1, Oca3, isa, Tyrp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra5, Acra-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Prss12
Name: serine protease 12 neurotrypsin (motopsin)
Synonyms: motopsin, Bssp-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: Tiul1, 8030445B08Rik, AIP5, SDRP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: 4933439M23Rik, mTAFII140
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209361
Homologene: 35415
Ss18
Name: SS18, subunit of BAF chromatin remodeling complex
Synonyms: Ssxt
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 268996
VEGA: 18
Homologene: 38080
Parvb
Name: parvin, beta
Synonyms: affixin, D15Gsk1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170736
Homologene: 8342
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: 5330434F23Rik, Vps34
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Miz1, Zfp100, mZ13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: E430008G22Rik, c-Abl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: CD45, T200, Ly-5, Lyt-4, B220
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Zbtb2
Name: zinc finger and BTB domain containing 2
Synonyms: LOC381990
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 381990
VEGA: 10
Homologene: 10837
Ceacam19
Name: CEA cell adhesion molecule 19
Synonyms: C130022P09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319930
Homologene: 49621
Clca4a
Name: chloride channel accessory 4A
Synonyms: Clca6, 9130020L07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: Zfp192, LD5-1, D430019P06Rik, 2510038J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93681
Homologene: 21268
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64297
Homologene: 9435
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Prr29
Name: proline rich 29
Synonyms: 2310007L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75573
Homologene: 130357
Synm
Name: synemin, intermediate filament protein
Synonyms: Synemin, 4930412K21Rik, Dmn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233335
Homologene: 9081
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Cadm2
Name: cell adhesion molecule 2
Synonyms: Igsf4d, 2900078E11Rik, A830029E02Rik, Necl3, SynCAM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Or5au1
Name: olfactory receptor family 5 subfamily AU member 1
Synonyms: Olfr221, GA_x6K02T2RJGY-959918-960853, GA_x6K02SYYB8M-929-258, MOR205-2, Olfr1514, MOR205-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258420
Homologene: 45823
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4931433A01Rik, 4930578N11Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76779
Homologene: 14831
Or8k3
Name: olfactory receptor family 8 subfamily K member 3
Synonyms: Olfr1047, GA_x6K02T2Q125-47703682-47702723, MOR188-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259014
Homologene: 133664
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Ikbke
Name: inhibitor of kappaB kinase epsilon
Synonyms: IKKepsilon, IKK-i
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56489
Homologene: 23168
Exo5
Name: exonuclease 5
Synonyms: Dem1, 3110037I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73172
Homologene: 41497
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, SIP1, Zfhx1b, Zfx1b, D130016B08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 4930471A21Rik, 5330407H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Mettl22
Name: methyltransferase 22, Kin17 lysine
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239706
Homologene: 16619
Atp6ap1l
Name: ATPase, H+ transporting, lysosomal accessory protein 1-like
Synonyms: EG435376
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435376
Homologene: 28130
Ccn6
Name: cellular communication network factor 6
Synonyms: LOC327743, Wisp3, CCN6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327743
VEGA: 10
Homologene: 77038
Or5w22
Name: olfactory receptor family 5 subfamily W member 22
Synonyms: MOR177-5, Olfr4-2, Olfr153, V5, GA_x6K02T2Q125-49033418-49034341
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110511
Homologene: 128127
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240726
Homologene: 57135
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Helios, Zfpn1a2, A730095J18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22779
Homologene: 22659
B4galt2
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53418
HGNC: HGNC:925
Homologene: 2804
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Uox
Name: urate oxidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22262
Homologene: 7584
Josd2
Name: Josephin domain containing 2
Synonyms: 1110007C05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66124
Homologene: 26696
Pramel6
Name: PRAME like 6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 347711
Homologene: 77635
Or52n2c
Name: olfactory receptor family 52 subfamily N member 2C
Synonyms: MOR34-3, GA_x6K02T2PBJ9-7554614-7553658, Olfr668
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259061
Homologene: 64947
Xbp1
Name: X-box binding protein 1
Synonyms: D11Ertd39e, TREB5, TREB-5, XBP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22433
Homologene: 3722
Taf7
Name: TATA-box binding protein associated factor 7
Synonyms: 55kDa, Taf2f, TAFII55
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24074
Homologene: 133942
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 12,989,927 bp
  • G to C, chromosome 1 at 19,104,478 bp
  • T to C, chromosome 1 at 69,539,042 bp
  • T to G, chromosome 1 at 97,125,813 bp
  • A to G, chromosome 1 at 127,471,564 bp
  • T to C, chromosome 1 at 131,259,218 bp
  • A to T, chromosome 1 at 138,113,562 bp
  • T to C, chromosome 2 at 9,951,160 bp
  • T to A, chromosome 2 at 31,801,655 bp
  • T to C, chromosome 2 at 45,110,496 bp
  • T to A, chromosome 2 at 86,228,387 bp
  • T to C, chromosome 2 at 86,298,646 bp
  • C to T, chromosome 2 at 87,510,422 bp
  • C to G, chromosome 2 at 87,532,741 bp
  • C to T, chromosome 2 at 135,973,071 bp
  • G to A, chromosome 2 at 172,249,154 bp
  • T to C, chromosome 3 at 19,982,022 bp
  • A to G, chromosome 3 at 123,447,399 bp
  • T to A, chromosome 3 at 144,957,298 bp
  • C to T, chromosome 3 at 146,624,577 bp
  • G to A, chromosome 4 at 19,650,299 bp
  • A to G, chromosome 4 at 80,840,781 bp
  • G to T, chromosome 4 at 100,952,118 bp
  • G to A, chromosome 4 at 111,547,272 bp
  • A to T, chromosome 4 at 117,876,967 bp
  • A to G, chromosome 4 at 120,921,537 bp
  • G to A, chromosome 4 at 141,463,383 bp
  • A to G, chromosome 5 at 103,501,612 bp
  • C to T, chromosome 6 at 121,654,505 bp
  • T to C, chromosome 7 at 19,882,592 bp
  • T to C, chromosome 7 at 24,979,304 bp
  • T to C, chromosome 7 at 44,471,154 bp
  • T to C, chromosome 7 at 67,736,061 bp
  • A to G, chromosome 7 at 101,500,442 bp
  • C to A, chromosome 7 at 104,925,645 bp
  • A to G, chromosome 7 at 118,984,577 bp
  • G to T, chromosome 7 at 127,522,145 bp
  • T to A, chromosome 8 at 72,733,490 bp
  • A to G, chromosome 8 at 85,740,349 bp
  • T to A, chromosome 8 at 95,264,424 bp
  • A to G, chromosome 9 at 54,998,063 bp
  • T to C, chromosome 10 at 4,369,711 bp
  • C to T, chromosome 10 at 39,154,987 bp
  • T to C, chromosome 11 at 5,521,005 bp
  • A to T, chromosome 11 at 43,218,957 bp
  • C to T, chromosome 11 at 106,375,236 bp
  • A to T, chromosome 12 at 8,008,261 bp
  • T to C, chromosome 12 at 70,054,534 bp
  • A to T, chromosome 13 at 21,525,227 bp
  • A to T, chromosome 13 at 90,883,722 bp
  • A to G, chromosome 14 at 52,035,445 bp
  • A to G, chromosome 15 at 12,861,706 bp
  • T to C, chromosome 15 at 84,303,872 bp
  • T to A, chromosome 16 at 3,928,612 bp
  • T to A, chromosome 16 at 8,488,891 bp
  • G to T, chromosome 16 at 66,784,828 bp
  • A to T, chromosome 18 at 14,651,088 bp
  • C to T, chromosome 18 at 30,324,562 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • A to G, chromosome 18 at 37,643,106 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6492 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044624-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.