Strain Name:
C57BL/6J-MtgxR6571Btlr/Mmmh
Stock Number:
044695-MU
Citation ID:
RRID:MMRRC_044695-MU
Other Names:
R6571 (G1)
Major Collection:

Strain Information

S1pr1
Name: sphingosine-1-phosphate receptor 1
Synonyms: Edg1, S1P1, S1P
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13609
HGNC: HGNC:3165
Homologene: 1071
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Trib2
Name: tribbles pseudokinase 2
Synonyms: TRB2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217410
Homologene: 41445
Rngtt
Name: RNA guanylyltransferase and 5'-phosphatase
Synonyms: mouse capping enzyme
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24018
Homologene: 37851
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17, D17Rp17e, MAPKKK4, Mekk4, MTK1, Tas, RP17, T-associated sex reversal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Dab2ip
Name: disabled 2 interacting protein
Synonyms: AIP1, 2310011D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69601
Homologene: 13058
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: 9530003A05Rik, PRO2405
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227634
Homologene: 19202
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, S17, Mastrin, Deepest, Astrin, s17, D11Bhm180e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71096
Homologene: 56834
Bche
Name: butyrylcholinesterase
Synonyms: C730038G20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12038
HGNC: HGNC:983
Homologene: 20065
Gm11437
Name: predicted gene 11437
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 628813
Homologene: 82346
Papss2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Synonyms: 1810018P12Rik, Sk2, Atpsk2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23972
VEGA: 19
HGNC: HGNC:8604
Homologene: 55840
Tnfrsf18
Name: tumor necrosis factor receptor superfamily, member 18
Synonyms: Gitr
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21936
Homologene: 48270
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22404
Homologene: 7997
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76713
Homologene: 66347
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Mmp25
Name: matrix metallopeptidase 25
Synonyms: MT6-MMP, F730048C11Rik, Leukolysin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240047
VEGA: 17
Homologene: 23375
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Facl6, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434172
Homologene: 45597
Septin8
Name: septin 8
Synonyms: Sepl, Sept8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20362
Homologene: 57205
Vmn2r33
Name: vomeronasal 2, receptor 33
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 624512
Homologene: 113703
Or6c38
Name: olfactory receptor family 6 subfamily C member 38
Synonyms: MOR114-4, GA_x6K02T2PULF-10779441-10778503, Olfr768
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258863
Homologene: 17159
Zfp747l1
Name: zinc finger protein 747 like 1
Synonyms: 9130019O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78921
Homologene: 118005
Gm6401
Name: predicted gene 6401
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 115486427
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 8,363,528 bp
  • T to C, chromosome 1 at 37,387,758 bp
  • T to A, chromosome 1 at 71,626,190 bp
  • A to G, chromosome 1 at 105,692,982 bp
  • A to T, chromosome 1 at 150,615,438 bp
  • T to A, chromosome 1 at 157,161,179 bp
  • A to T, chromosome 2 at 25,939,500 bp
  • T to C, chromosome 2 at 35,712,890 bp
  • T to C, chromosome 2 at 60,628,456 bp
  • G to T, chromosome 3 at 73,701,491 bp
  • A to C, chromosome 3 at 86,360,060 bp
  • A to G, chromosome 3 at 115,711,803 bp
  • T to A, chromosome 4 at 33,379,413 bp
  • T to A, chromosome 4 at 156,028,319 bp
  • A to G, chromosome 7 at 7,563,669 bp
  • A to G, chromosome 7 at 41,288,575 bp
  • A to G, chromosome 7 at 45,280,879 bp
  • A to G, chromosome 7 at 118,184,514 bp
  • T to C, chromosome 7 at 127,385,138 bp
  • A to C, chromosome 10 at 129,093,121 bp
  • A to G, chromosome 11 at 53,537,163 bp
  • A to G, chromosome 11 at 54,325,564 bp
  • G to T, chromosome 11 at 78,321,269 bp
  • T to C, chromosome 11 at 84,156,212 bp
  • T to C, chromosome 12 at 15,794,059 bp
  • A to T, chromosome 13 at 59,717,455 bp
  • T to A, chromosome 14 at 41,965,495 bp
  • T to C, chromosome 15 at 11,065,101 bp
  • C to T, chromosome 16 at 4,119,806 bp
  • A to T, chromosome 16 at 36,969,306 bp
  • T to C, chromosome 17 at 12,242,692 bp
  • T to C, chromosome 17 at 23,639,896 bp
  • G to A, chromosome 17 at 32,359,324 bp
  • G to A, chromosome 19 at 32,651,942 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6571 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044695-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.