Strain Name:
C57BL/6J-MtgxR6573Btlr/Mmmh
Stock Number:
044697-MU
Citation ID:
RRID:MMRRC_044697-MU
Other Names:
R6573 (G1)
Major Collection:

Strain Information

Pmp22
Name: peripheral myelin protein 22
Synonyms: TRE002, Gas-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18858
HGNC: HGNC:9118
Homologene: 7482
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, Zfp406, LOC380993
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: 8430435B07Rik, LOC237436
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Gfod1
Name: glucose-fructose oxidoreductase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328232
VEGA: 13
Homologene: 49581
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, S17, Mastrin, Deepest, Astrin, s17, D11Bhm180e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Zfp317
Name: zinc finger protein 317
Synonyms: D230022C05Rik, Zfp67, Zfp75, KRAB9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244713
Homologene: 36389
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, Olfaxin, A230083H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Megf9
Name: multiple EGF-like-domains 9
Synonyms: Egfl5, 4933405H16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230316
HGNC: HGNC:3234
Homologene: 18209
Fbxo34
Name: F-box protein 34
Synonyms: 2900057B08Rik, 5830426G16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78938
VEGA: 14
Homologene: 12713
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, calsyntenin-1, 1810034E21Rik, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Tnnt1
Name: troponin T1, skeletal, slow
Synonyms: Tnt, ssTnT, sTnT, skeletal muscle slow-twitch TnT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21955
Homologene: 20704
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Spata6
Name: spermatogenesis associated 6
Synonyms: KRP, Hash, 1700062C23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67946
Homologene: 10410
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74183
Homologene: 135954
Cstf2t
Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms: 64kDa, tCstF-64
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83410
VEGA: 19
Homologene: 80230
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Or2ag1b
Name: olfactory receptor family 2 subfamily AG member 1B
Synonyms: GA_x6K02T2PBJ9-9067220-9066273, MOR283-9, Olfr694
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258444
Homologene: 79345
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74468
Homologene: 50610
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55961
Homologene: 31893
Mrgprg
Name: MAS-related GPR, member G
Synonyms: MrgG, LOC381974
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381974
Homologene: 28580
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG383258, Vmn2r119, EG668547
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Pgpep1
Name: pyroglutamyl-peptidase I
Synonyms: PGP-I, Pcp, 2810003H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66522
Homologene: 9793
Efcab3
Name: EF-hand calcium binding domain 3
Synonyms: Gm11639, Efcab15, 4921510J17Rik, Gm11639, Efcab13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108167860
Homologene: 18304
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: 1600029H12Rik, Psg30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Or8k16
Name: olfactory receptor family 8 subfamily K member 16
Synonyms: GA_x6K02T2Q125-47170431-47171372, MOR187-3, Olfr1008
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258866
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933405P16Rik, 4933425F06Rik, Als2cr12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108812
Homologene: 51399
Slc10a5
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 5
Synonyms: LOC241877
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241877
Homologene: 78106
Gzme
Name: granzyme E
Synonyms: Ctla6, CCP3, Ctla-6, MCSP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14942
VEGA: 14
Homologene: 133275
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Nmi
Name: N-myc (and STAT) interactor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64685
HGNC: HGNC:7854
Homologene: 3441
Edf1
Name: endothelial differentiation-related factor 1
Synonyms: hypothetical protein 1-9, 0610008L11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59022
HGNC: HGNC:3164
Homologene: 2809
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,666,844 bp
  • G to T, chromosome 2 at 25,561,863 bp
  • T to A, chromosome 2 at 51,950,069 bp
  • C to T, chromosome 2 at 85,689,999 bp
  • A to C, chromosome 2 at 112,251,043 bp
  • A to T, chromosome 3 at 10,335,050 bp
  • A to T, chromosome 4 at 70,488,172 bp
  • T to A, chromosome 4 at 102,430,162 bp
  • T to A, chromosome 4 at 111,779,279 bp
  • A to G, chromosome 4 at 149,643,689 bp
  • C to A, chromosome 4 at 156,218,673 bp
  • T to C, chromosome 6 at 24,137,095 bp
  • T to C, chromosome 6 at 24,891,552 bp
  • C to A, chromosome 7 at 4,514,334 bp
  • A to G, chromosome 7 at 17,713,447 bp
  • A to T, chromosome 7 at 106,689,463 bp
  • T to C, chromosome 7 at 143,764,596 bp
  • A to G, chromosome 8 at 70,650,615 bp
  • T to C, chromosome 8 at 120,567,797 bp
  • T to C, chromosome 9 at 19,645,254 bp
  • T to A, chromosome 10 at 52,155,010 bp
  • C to A, chromosome 10 at 89,422,210 bp
  • C to T, chromosome 11 at 63,158,273 bp
  • C to T, chromosome 11 at 78,314,182 bp
  • A to T, chromosome 11 at 105,080,635 bp
  • G to A, chromosome 12 at 103,061,388 bp
  • A to T, chromosome 13 at 38,196,862 bp
  • C to T, chromosome 13 at 43,200,365 bp
  • T to A, chromosome 14 at 16,398,991 bp
  • A to T, chromosome 14 at 47,529,667 bp
  • T to A, chromosome 14 at 56,118,826 bp
  • T to C, chromosome 15 at 68,165,854 bp
  • A to T, chromosome 17 at 20,042,225 bp
  • C to T, chromosome 17 at 55,592,996 bp
  • G to T, chromosome 19 at 17,121,157 bp
  • G to T, chromosome 19 at 17,121,158 bp
  • T to A, chromosome 19 at 23,988,502 bp
  • A to G, chromosome 19 at 31,083,780 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6573 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044697-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.