Strain Name:
C57BL/6J-MtgxR6594Btlr/Mmmh
Stock Number:
044718-MU
Citation ID:
RRID:MMRRC_044718-MU
Other Names:
R6594 (G1)
Major Collection:

Strain Information

Vcp
Name: valosin containing protein
Synonyms: p97, CDC48, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, Semaa, semaV, SemA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Mycn
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Synonyms: bHLHe37, N-myc, Nmyc, Nmyc1, Nmyc-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18109
HGNC: HGNC:7559
Homologene: 3922
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Ddx55
Name: DEAD box helicase 55
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 55, 2810021H22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Ccar2
Name: cell cycle activator and apoptosis regulator 2
Synonyms: 2610301G19Rik, Dbc1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219158
VEGA: 14
Homologene: 10910
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Pon1
Name: paraoxonase 1
Synonyms: Pon
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18979
HGNC: HGNC:9204
Homologene: 68058
Kars1
Name: lysyl-tRNA synthetase 1
Synonyms: LysRS, D8Wsu108e, D8Ertd698e, Kars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 85305
HGNC: HGNC:6215
Homologene: 4053
Eri1
Name: exoribonuclease 1
Synonyms: Thex1, Eri1, 3110010F15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67276
Homologene: 32651
Chchd10
Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Synonyms: Ndg2, 1620401E04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103172
VEGA: 10
Homologene: 27885
Surf6
Name: surfeit gene 6
Synonyms: D2Wsu129e, Surf-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20935
Homologene: 133981
Traf7
Name: TNF receptor-associated factor 7
Synonyms: RFWD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224619
Homologene: 12998
Lrrc20
Name: leucine rich repeat containing 20
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216011
VEGA: 10
Homologene: 45208
Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms: Ly-m10, Mdu1, Cd98, 4F2HC, Mgp-2hc, Ly-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17254
Homologene: 1795
Golm1
Name: golgi membrane protein 1
Synonyms: Golph2, GP73, PSEC0257, D030064E01Rik, 2310001L02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Apn, aminopeptidase N, Cd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, N-3 kinesin, Kns1, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Fscn1
Name: fascin actin-bundling protein 1
Synonyms: Fan1, fascin-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14086
Homologene: 48164
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: C motif-1/lymphotactin receptor, Ccxcr1, GPR5, XCR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Gm11437
Name: predicted gene 11437
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 628813
Homologene: 82346
Ube2m
Name: ubiquitin-conjugating enzyme E2M
Synonyms: UBC12, 2510040H03Rik, Ubc-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22192
Homologene: 2952
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Ms4a4a
Name: membrane-spanning 4-domains, subfamily A, member 4A
Synonyms: EG666907
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 666907
Homologene: 103874
Cd69
Name: CD69 antigen
Synonyms: VEA, AIM, 5830438K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12515
HGNC: HGNC:1694
Homologene: 128584
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: Mmu-OASL, M1204
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23962
Homologene: 128369
Or10s1
Name: olfactory receptor family 10 subfamily S member 1
Synonyms: MOR223-4, GA_x6K02T2PVTD-33772307-33773260, Olfr982
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258853
VEGA: 9
Homologene: 17415
Serpinb8
Name: serine (or cysteine) peptidase inhibitor, clade B, member 8
Synonyms: CAP-2, NK10, ovalbumin, Spi8, CAP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20725
HGNC: HGNC:8952
Homologene: 74445
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73094
Homologene: 13001
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Bcl2a1b
Name: B cell leukemia/lymphoma 2 related protein A1b
Synonyms: A1-b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12045
HGNC: HGNC:991
Homologene: 2988
Ninj2
Name: ninjurin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 29862
HGNC: HGNC:7825
Homologene: 9555
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, Cab140, CBP-140, Grp170, 140 kDa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12282
Homologene: 4658
Or7g19
Name: olfactory receptor family 7 subfamily G member 19
Synonyms: GA_x6K02T2PVTD-12687800-12688738, MOR153-1, Olfr832
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Defa41
Name: defensin, alpha, 41
Synonyms: Gm15293
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041759
Homologene: 113382
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434246
Homologene: 66924
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Mecr
Name: mitochondrial trans-2-enoyl-CoA reductase
Synonyms: Nrbf1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26922
Homologene: 5362
Or2r11
Name: olfactory receptor family 2 subfamily R member 11
Synonyms: GA_x6K02T2P3E9-5100053-5100994, MOR257-4, Olfr458
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258436
Homologene: 133704
Haus4
Name: HAUS augmin-like complex, subunit 4
Synonyms: D14Ertd500e, 9430093H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219072
VEGA: 14
Homologene: 9854
Unc119
Name: unc-119 lipid binding chaperone
Synonyms: UNC119, MRG4, Rg4, HRG4, Rtg4, Unc119h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22248
Homologene: 3778
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, A830022B16Rik, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,021,313 bp
  • T to C, chromosome 1 at 107,597,471 bp
  • T to C, chromosome 1 at 188,910,798 bp
  • G to T, chromosome 2 at 26,902,749 bp
  • T to C, chromosome 2 at 69,439,923 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • A to G, chromosome 3 at 64,389,310 bp
  • G to T, chromosome 3 at 123,293,763 bp
  • T to C, chromosome 3 at 154,259,023 bp
  • A to T, chromosome 4 at 42,993,826 bp
  • T to A, chromosome 4 at 102,962,479 bp
  • T to A, chromosome 4 at 131,854,693 bp
  • G to A, chromosome 5 at 114,906,775 bp
  • A to G, chromosome 5 at 124,566,925 bp
  • C to T, chromosome 5 at 142,970,028 bp
  • A to G, chromosome 6 at 5,185,314 bp
  • T to C, chromosome 6 at 23,113,433 bp
  • G to A, chromosome 6 at 42,364,691 bp
  • A to T, chromosome 6 at 42,460,375 bp
  • A to T, chromosome 6 at 120,198,789 bp
  • A to G, chromosome 6 at 129,269,574 bp
  • T to A, chromosome 6 at 146,190,480 bp
  • T to A, chromosome 7 at 3,736,499 bp
  • C to A, chromosome 7 at 13,037,690 bp
  • T to C, chromosome 7 at 41,837,111 bp
  • T to C, chromosome 7 at 43,567,277 bp
  • T to A, chromosome 7 at 79,841,361 bp
  • T to C, chromosome 7 at 85,749,684 bp
  • T to C, chromosome 7 at 128,010,048 bp
  • A to G, chromosome 8 at 21,202,455 bp
  • T to C, chromosome 8 at 35,482,533 bp
  • T to C, chromosome 8 at 111,993,667 bp
  • T to C, chromosome 9 at 18,944,831 bp
  • T to C, chromosome 9 at 40,074,943 bp
  • T to C, chromosome 9 at 44,389,322 bp
  • A to C, chromosome 9 at 89,207,594 bp
  • A to T, chromosome 9 at 107,598,826 bp
  • A to G, chromosome 9 at 123,856,244 bp
  • G to A, chromosome 10 at 61,482,446 bp
  • A to C, chromosome 10 at 75,936,324 bp
  • A to T, chromosome 11 at 9,294,632 bp
  • T to A, chromosome 11 at 78,347,220 bp
  • C to T, chromosome 11 at 84,164,560 bp
  • A to T, chromosome 11 at 86,785,773 bp
  • G to A, chromosome 11 at 115,798,286 bp
  • T to C, chromosome 12 at 12,940,050 bp
  • T to C, chromosome 13 at 59,664,227 bp
  • T to C, chromosome 13 at 92,513,818 bp
  • C to A, chromosome 14 at 54,543,811 bp
  • A to T, chromosome 14 at 64,031,677 bp
  • G to A, chromosome 14 at 70,140,476 bp
  • A to G, chromosome 15 at 50,830,955 bp
  • G to A, chromosome 15 at 102,110,559 bp
  • A to G, chromosome 17 at 24,509,839 bp
  • A to C, chromosome 18 at 37,011,182 bp
  • T to C, chromosome 19 at 8,708,046 bp
  • C to A, chromosome 19 at 11,386,414 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6594 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044718-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.