Strain Name:
C57BL/6J-MtgxR6610Btlr/Mmmh
Stock Number:
044733-MU
Citation ID:
RRID:MMRRC_044733-MU
Other Names:
R6610 (G1)
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Trim32
Name: tripartite motif-containing 32
Synonyms: 3f3, BBS11, 1810045E12Rik, Zfp117
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69807
Homologene: 36327
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Etl4
Name: enhancer trap locus 4
Synonyms: Skt, Sickle tail, 6620402G01Rik, E330027G05Rik, 9430077C05Rik, Etl-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Sec24a
Name: SEC24 homolog A, COPII coat complex component
Synonyms: 9430090N21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77371
Homologene: 70131
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84505
Homologene: 32157
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: D15Ertd682e, 2310042P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Elp1
Name: elongator complex protein 1
Synonyms: Ikbkap, IKAP, 3110040G09Rik, C78473
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: 2810034J18Rik, b5/b5r, Ncb5or, B5+B5R
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 266690
Homologene: 69207
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Dnahc8, Hst6.7b, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Stk32b
Name: serine/threonine kinase 32B
Synonyms: 2510009F08Rik, YANK2, Stk32, STKG6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64293
Homologene: 48654
Zfp534
Name: zinc finger protein 534
Synonyms: Gm13159
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100503584
Homologene: 133076
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: Atp1al1, cHKA, ATPase H+K+-transporting, alpha 2, HKalpha2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Eif4e1b
Name: eukaryotic translation initiation factor 4E family member 1B
Synonyms: Eif4eloo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218268
Homologene: 100945
Ttn
Name: titin
Synonyms: mdm, D830007G01Rik, shru, 1100001C23Rik, D330041I19Rik, 2310057K23Rik, 2310036G12Rik, 2310074I15Rik, L56, connectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Scara3
Name: scavenger receptor class A, member 3
Synonyms: C130058N24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219151
VEGA: 14
Homologene: 9437
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Neu2
Name: neuraminidase 2
Synonyms: MBS, MSS, MTS, brain sialidase, cystolic sialidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23956
HGNC: HGNC:7759
Homologene: 3927
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: D16Ium24, GluK5, Glurbeta1, Glur5, A830007B11Rik, Glur-5, D16Ium24e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: Gpcr19-rs1, Lhr, LH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: Kv3.2, KShIIIA
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Ptar1
Name: protein prenyltransferase alpha subunit repeat containing 1
Synonyms: 2010013L17Rik, 1700084D09Rik, 4930428J16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72351
VEGA: 19
Homologene: 34254
Zfp426
Name: zinc finger protein 426
Synonyms: Zfo61, KRAB1, Zfp68-rs1, 2900057C04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235028
Homologene: 23435
Mymk
Name: myomaker, myoblast fusion factor
Synonyms: 1110002H13Rik, Tmem8c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66139
Homologene: 11925
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226143
Homologene: 115563
Cdc20b
Name: cell division cycle 20B
Synonyms: EG622422, EG238896
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238896
Homologene: 65056
Cfh
Name: complement component factor h
Synonyms: Sas1, Sas-1, Mud-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: tTGas, tissue transglutaminase, G[a]h, TG C, TGase2, protein-glutamine gamma-glutamyltransferase, TG2, tTG
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21817
Homologene: 3391
Cbx2
Name: chromobox 2
Synonyms: M33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12416
HGNC: HGNC:1552
Homologene: 7256
Vmn1r123
Name: vomeronasal 1 receptor 123
Synonyms: LOC384695, Gm1446
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384695
Homologene: 104166
Cep20
Name: centrosomal protein 20
Synonyms: Fopnl, 0610037P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66086
Homologene: 11919
Vmn2r31
Name: vomeronasal 2, receptor 31
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042591
Homologene: 113703
Tcte2
Name: t-complex-associated testis expressed 2
Synonyms: Tcte-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21646
Igkv15-103
Name: immunoglobulin kappa chain variable 15-103
Synonyms: Igk-V32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692169
Pdcd7
Name: programmed cell death 7
Synonyms: ES18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50996
VEGA: 9
HGNC: HGNC:8767
Homologene: 4170
AB124611
Name: cDNA sequence AB124611
Synonyms: HIDE1, LOC382062
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382062
Homologene: 87291
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,655,087 bp
  • A to T, chromosome 1 at 87,596,685 bp
  • A to T, chromosome 1 at 140,101,748 bp
  • G to A, chromosome 2 at 20,713,369 bp
  • G to T, chromosome 2 at 27,067,393 bp
  • G to A, chromosome 2 at 76,749,329 bp
  • T to A, chromosome 2 at 150,823,966 bp
  • C to A, chromosome 2 at 158,143,100 bp
  • G to T, chromosome 3 at 95,328,577 bp
  • A to G, chromosome 4 at 56,758,236 bp
  • G to A, chromosome 4 at 65,615,071 bp
  • A to G, chromosome 4 at 141,916,396 bp
  • C to T, chromosome 4 at 147,674,490 bp
  • G to A, chromosome 5 at 37,448,678 bp
  • A to T, chromosome 6 at 46,015,257 bp
  • A to T, chromosome 6 at 68,437,633 bp
  • A to T, chromosome 7 at 7,384,589 bp
  • A to G, chromosome 7 at 21,162,590 bp
  • A to G, chromosome 7 at 100,455,298 bp
  • G to C, chromosome 7 at 141,640,433 bp
  • T to C, chromosome 8 at 43,521,153 bp
  • T to G, chromosome 8 at 104,950,106 bp
  • T to C, chromosome 9 at 20,473,093 bp
  • G to T, chromosome 9 at 21,108,016 bp
  • A to T, chromosome 9 at 21,526,265 bp
  • T to A, chromosome 9 at 58,069,136 bp
  • T to A, chromosome 9 at 65,354,683 bp
  • T to G, chromosome 9 at 87,059,417 bp
  • G to C, chromosome 10 at 112,271,856 bp
  • A to T, chromosome 10 at 127,664,338 bp
  • A to T, chromosome 10 at 130,425,969 bp
  • C to T, chromosome 11 at 51,696,656 bp
  • A to G, chromosome 11 at 119,024,210 bp
  • A to G, chromosome 13 at 54,784,315 bp
  • C to T, chromosome 13 at 113,064,262 bp
  • A to G, chromosome 14 at 56,374,556 bp
  • A to G, chromosome 14 at 65,931,221 bp
  • T to C, chromosome 15 at 63,825,008 bp
  • T to C, chromosome 15 at 97,688,168 bp
  • T to C, chromosome 15 at 98,565,101 bp
  • TTGTG to TTG, chromosome 16 at 14,300,145 bp
  • A to G, chromosome 16 at 88,034,312 bp
  • G to A, chromosome 17 at 13,727,988 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to T, chromosome 17 at 88,769,879 bp
  • A to G, chromosome 19 at 23,717,844 bp
  • A to G, chromosome 19 at 44,007,081 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6610 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044733-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.