Strain Name:
C57BL/6J-MtgxR6640Btlr/Mmmh
Stock Number:
044761-MU
Citation ID:
RRID:MMRRC_044761-MU
Other Names:
R6640 (G1)
Major Collection:

Strain Information

Gpx1
Name: glutathione peroxidase 1
Synonyms: Gpx, GSHPx-1, GPx-1, CGPx, cellular GPx
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14775
HGNC: HGNC:4553
Homologene: 20155
Elovl5
Name: ELOVL fatty acid elongase 5
Synonyms: 1110059L23Rik, ELOVL family member 5, elongation of long chain fatty acids (yeast)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68801
Homologene: 41449
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20687
Homologene: 7952
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, DAP-Kinase, D13Ucla1, 2310039H24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Raver2
Name: ribonucleoprotein, PTB-binding 2
Synonyms: A430091O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242570
Homologene: 18829
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: EAAC1, D130048G10Rik, MEAAC1, EAAT3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20510
Homologene: 20881
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: Xtrp2, XT2, D630001K16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Rab33b
Name: RAB33B, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19338
Homologene: 9642
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 1110064N14Rik, 0610030A14Rik, mDC2, MGAT1, Dgat2l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68393
Homologene: 105237
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Klri2
Name: killer cell lectin-like receptor family I member 2
Synonyms: A530090P03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320407
Homologene: 86736
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: 9130023G24Rik, RNF158
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Synonyms: A9'
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394435
Homologene: 85959
Aoc1l1
Name: amine oxidase copper containing 1-like 1
Synonyms: Doxl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243376
HGNC: HGNC:80
Homologene: 19443
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, C030044P22Rik, Melk2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232664
Homologene: 23378
Or8k16
Name: olfactory receptor family 8 subfamily K member 16
Synonyms: GA_x6K02T2Q125-47170431-47171372, MOR187-3, Olfr1008
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258866
Or2ag13
Name: olfactory receptor family 2 subfamily AG member 13
Synonyms: Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258591
Homologene: 133597
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Pigm
Name: phosphatidylinositol glycan anchor biosynthesis, class M
Synonyms: C920011G20Rik, 4933437L05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67556
Homologene: 6274
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Fbxl21
Name: F-box and leucine-rich repeat protein 21
Synonyms: FBL3B, FBXL3B, Psttm, D630045D17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 213311
Homologene: 78724
Hoxd1
Name: homeobox D1
Synonyms: Hox-4.9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15429
HGNC: HGNC:5132
Homologene: 7772
Rpl15-ps6
Name: ribosomal protein L15, pseudogene 6
Synonyms: Gm10020
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100039748
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 78,523,774 bp
  • G to T, chromosome 1 at 80,533,838 bp
  • A to C, chromosome 1 at 88,107,794 bp
  • T to C, chromosome 1 at 172,377,687 bp
  • A to T, chromosome 2 at 25,447,003 bp
  • A to G, chromosome 2 at 72,971,114 bp
  • T to A, chromosome 2 at 74,763,262 bp
  • T to A, chromosome 2 at 85,689,935 bp
  • C to CGTG, chromosome 2 at 98,663,807 bp
  • A to G, chromosome 3 at 51,484,479 bp
  • A to G, chromosome 4 at 45,803,868 bp
  • C to T, chromosome 4 at 101,131,303 bp
  • A to G, chromosome 6 at 29,412,960 bp
  • A to G, chromosome 6 at 48,977,671 bp
  • A to T, chromosome 6 at 73,024,293 bp
  • A to T, chromosome 6 at 128,553,285 bp
  • G to C, chromosome 6 at 129,732,195 bp
  • G to A, chromosome 7 at 46,261,743 bp
  • T to A, chromosome 7 at 106,714,040 bp
  • C to A, chromosome 9 at 77,979,913 bp
  • A to G, chromosome 9 at 108,340,096 bp
  • C to T, chromosome 10 at 77,937,826 bp
  • T to A, chromosome 10 at 105,573,749 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • T to A, chromosome 13 at 56,537,009 bp
  • A to G, chromosome 13 at 60,716,814 bp
  • T to A, chromosome 13 at 73,664,282 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to G, chromosome 15 at 35,617,696 bp
  • G to T, chromosome 15 at 52,477,620 bp
  • T to C, chromosome 15 at 99,241,768 bp
  • T to C, chromosome 17 at 14,673,368 bp
  • T to A, chromosome 18 at 42,101,640 bp
  • T to A, chromosome 19 at 22,978,582 bp
  • T to C, chromosome 19 at 28,894,570 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6640 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044761-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.