Strain Name:
C57BL/6J-MtgxR6644Btlr/Mmmh
Stock Number:
044765-MU
Citation ID:
RRID:MMRRC_044765-MU
Other Names:
R6644 (G1)
Major Collection:

Strain Information

B4galnt1
Name: beta-1,4-N-acetyl-galactosaminyl transferase 1
Synonyms: beta1,4GalNAC-T, GM2/GD2 synthase, GalNAcT, Gal-NAc-T, 4933429D13Rik, Ggm-2, Galgt1, GalNAc-T, Ggm2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14421
VEGA: 10
HGNC: HGNC:4117
Homologene: 1133
Myo5a
Name: myosin VA
Synonyms: MVa, Myo5, flail, 9630007J19Rik, MyoVA, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Itga6
Name: integrin alpha 6
Synonyms: 5033401O05Rik, Cd49f
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Cdk18
Name: cyclin dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17, D17Rp17e, MAPKKK4, Mekk4, MTK1, Tas, RP17, T-associated sex reversal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Dnm1l
Name: dynamin 1-like
Synonyms: Drp1, Dnmlp1, 6330417M19Rik, python
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9630002H22Rik, 9430093I07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Gnai3
Name: G protein subunit alpha i3
Synonyms: Galphai3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14679
HGNC: HGNC:4387
Homologene: 55975
Klhl7
Name: kelch-like 7
Synonyms: 2700038B03Rik, D5Ertd363e, SBBI26, Klhl6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52323
Homologene: 10317
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Ube2d1
Name: ubiquitin-conjugating enzyme E2D 1
Synonyms: UBCH5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216080
Homologene: 20714
Cabp7
Name: calcium binding protein 7
Synonyms: calneuron II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192650
Homologene: 16364
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Hnrnph3
Name: heterogeneous nuclear ribonucleoprotein H3
Synonyms: Hnrph3, hnRNP 2H9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432467
HGNC: HGNC:5043
Homologene: 11012
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: 145kDa, SF3b145, SF3b1, B230398H18Rik, SF3b150, 2610311M13Rik, 2810441F20Rik, SAP145
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Dner
Name: delta/notch-like EGF repeat containing
Synonyms: BET, A930026D19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227325
Homologene: 26722
Uba7
Name: ubiquitin-like modifier activating enzyme 7
Synonyms: Ube1l, 1300004C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74153
Homologene: 2502
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Abhd14a
Name: abhydrolase domain containing 14A
Synonyms: 1110013B16Rik, Dorz1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68644
Homologene: 22889
Mfap5
Name: microfibrillar associated protein 5
Synonyms: MAGP-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50530
Homologene: 2599
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94094
Homologene: 128238
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: 0610038K03Rik, Pbld
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68371
VEGA: 10
Homologene: 41470
Or4c116
Name: olfactory receptor family 4 subfamily C member 116
Synonyms: MOR233-3, GA_x6K02T2Q125-50591144-50590209, Olfr1221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258904
Homologene: 73987
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Zbtb37
Name: zinc finger and BTB domain containing 37
Synonyms: D430004I08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240869
Homologene: 13048
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109082
Homologene: 82571
Zfp119b
Name: zinc finger protein 119b
Synonyms: BC031441
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240120
Immp1l
Name: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms: 1500034J20Rik, 2610528O17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66541
Homologene: 41747
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22626
Homologene: 65865
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Stx5a
Name: syntaxin 5A
Synonyms: syntaxin 5, 0610031F24Rik, D19Ertd627e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56389
Homologene: 2381
Cryba4
Name: crystallin, beta A4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12959
HGNC: HGNC:2396
Homologene: 1422
Garin2
Name: golgi associated RAB2 interactor 2
Synonyms: 4921509E07Rik, Fam71d, 4930516C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70897
Homologene: 49887
Czib
Name: CXXC motif containing zinc binding protein
Synonyms: 0610037L13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74098
Homologene: 41206
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209760
Homologene: 36424
Or51aa2
Name: olfactory receptor family 51 subfamily AA member 2
Synonyms: Olfr612, MOR15-3, EG545985, GA_x6K02T2PBJ9-6251685-6250741
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545985
Homologene: 79675
Ifi211
Name: interferon activated gene 211
Synonyms: Ifi205b, Mnda
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381308
Homologene: 115929
Cbr3
Name: carbonyl reductase 3
Synonyms: 1110001J05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 109857
HGNC: HGNC:1549
Homologene: 20332
Eif1ad16
Name: eukaryotic translation initiation factor 1A domain containing 16
Synonyms: Gm6803
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627873
VEGA: 12
Gm10332
Name: predicted gene 10332
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,836,741 bp
  • A to G, chromosome 1 at 75,128,547 bp
  • T to C, chromosome 1 at 84,395,707 bp
  • G to A, chromosome 1 at 132,122,069 bp
  • G to A, chromosome 1 at 161,032,073 bp
  • C to T, chromosome 1 at 173,905,552 bp
  • G to A, chromosome 2 at 71,841,124 bp
  • A to G, chromosome 2 at 89,111,981 bp
  • A to G, chromosome 2 at 105,937,045 bp
  • A to C, chromosome 2 at 120,695,772 bp
  • A to G, chromosome 3 at 108,123,536 bp
  • T to G, chromosome 4 at 107,894,922 bp
  • A to G, chromosome 5 at 24,149,246 bp
  • T to C, chromosome 5 at 112,246,762 bp
  • T to C, chromosome 6 at 122,520,596 bp
  • C to A, chromosome 7 at 103,539,058 bp
  • T to C, chromosome 7 at 104,261,037 bp
  • A to G, chromosome 7 at 118,538,162 bp
  • A to G, chromosome 9 at 75,146,967 bp
  • T to C, chromosome 9 at 106,444,273 bp
  • A to G, chromosome 9 at 107,981,472 bp
  • T to A, chromosome 9 at 111,364,834 bp
  • C to T, chromosome 10 at 63,018,893 bp
  • T to A, chromosome 10 at 63,075,063 bp
  • A to G, chromosome 10 at 71,256,700 bp
  • C to T, chromosome 10 at 80,008,764 bp
  • T to C, chromosome 10 at 127,171,793 bp
  • C to T, chromosome 11 at 4,740,396 bp
  • A to T, chromosome 11 at 6,214,013 bp
  • G to T, chromosome 11 at 6,214,014 bp
  • A to G, chromosome 11 at 78,026,092 bp
  • G to A, chromosome 11 at 102,668,460 bp
  • T to A, chromosome 11 at 107,632,261 bp
  • A to G, chromosome 12 at 8,009,077 bp
  • T to A, chromosome 12 at 78,715,286 bp
  • A to G, chromosome 12 at 88,018,690 bp
  • G to A, chromosome 13 at 50,423,219 bp
  • A to G, chromosome 13 at 50,702,035 bp
  • G to T, chromosome 13 at 67,070,721 bp
  • C to T, chromosome 13 at 68,668,552 bp
  • A to G, chromosome 13 at 111,752,449 bp
  • T to A, chromosome 14 at 54,820,159 bp
  • T to C, chromosome 14 at 96,517,918 bp
  • T to C, chromosome 16 at 16,329,873 bp
  • A to G, chromosome 16 at 93,690,511 bp
  • A to G, chromosome 17 at 12,232,410 bp
  • T to C, chromosome 17 at 55,939,148 bp
  • C to G, chromosome 19 at 4,749,012 bp
  • A to T, chromosome 19 at 5,279,964 bp
  • A to T, chromosome 19 at 8,755,248 bp
  • A to G, chromosome 19 at 16,744,919 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6644 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044765-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.